IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice

Autor: Paurvi Shinde, Heather L. Howie, Tamara C. Stegmann, Ariel M. Hay, Hayley R. Waterman, Zoltan Szittner, Arthur E. H. Bentlage, Linda Kapp, Suzanne N. Lissenberg-Thunnissen, Gillian Dekkers, Richard B. M. Schasfoort, Sarah J. Ratcliffe, Mark E. Smolkin, Gestur Vidarsson, C. Ellen van der Schoot, Krystalyn E. Hudson, James C. Zimring

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

It has long been appreciated that immunoglobulins are not just the effector endpoint of humoral immunity, but rather have a complex role in regulating antibody responses themselves. Donor derived anti-RhD IgG has been used for over 50 years as an imm

Externí odkaz: https://doaj.org/article/5ced9a8f9c86426f90e7e02309b97636

Serological blind spots for variants of human IgG3 and IgG4 by a commonly used anti-immunoglobulin reagent

Autor: Xiaohong Wang, Tamara C. Stegmann, Heather L. Howie, Jenna N. Lebedev, Yanyun Wu, James C. Zimring, James P. AuBuchon, Linda M. Kapp, Lay See Er, Gestur Vidarsson, Meghan Delaney

Publikováno v: Transfusion. 56:2953-2962

BACKGROUND Human immunoglobulin G (IgG) includes four different subtypes (IgG1, IgG2, IgG3, and IgG4), and it is also now appreciated that there are genetic variations within IgG subtypes (called isoallotypes). Twenty-nine different isoallotypes have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96175e0c00ad4148a5bf4201c9c51dd2
https://doi.org/10.1111/trf.13812

Frequency and characterization of known and novel RHD variant alleles in 37 782 Dutch D-negative pregnant women

Autor: Tamara C. Stegmann, C. Ellen van der Schoot, Peter C. Ligthart, Renate Bijman, Masja de Haas, Florentine F. Thurik, Bernadette Bossers, Goedele Cheroutre, Remco Jonkers, Lonneke Haer-Wigman, Barbera Veldhuisen

Publikováno v: British Journal of Haematology, 173, 469-79
British journal of haematology, 173(3), 469-479. Wiley-Blackwell
British Journal of Haematology, 173, 3, pp. 469-79

Contains fulltext : 167810.pdf (Publisher’s version ) (Open Access) To guide anti-D prophylaxis, Dutch D- pregnant women are offered a quantitative fetal-RHD-genotyping assay to determine the RHD status of their fetus. This allowed us to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898e82803af12f4b8d96fea8a00c3506
http://hdl.handle.net/2066/167810

Impact of genetic variation in the SMIM1 gene on Vel expression levels

Autor: Lonneke, Haer-Wigman, Tamara C, Stegmann, Shabnam, Solati, Aïcha, Ait Soussan, Erik, Beckers, Pim, van der Harst, Marga, van Hulst-Sundermeijer, Peter, Ligthart, Dick, van Rhenen, Hein, Schepers, Masja, de Haas, C Ellen, van der Schoot

Publikováno v: Transfusion. 55(6 Pt 2)

Serologic determination of the Vel- phenotype is challenging due to variable Vel expression levels. In this study we investigated the genetic basis for weak Vel expression levels and developed a high-throughput genotyping assay to detect Vel- donors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7dff330577a2b8ef7a2b2f7f71d50696
https://pubmed.ncbi.nlm.nih.gov/25647324

A Novel RHCE*ce Variant Allele Is Highly Frequent in Chinese D-Negative Individuals and Results in C-Expression

Autor: Tamara C. Stegmann, R Q Zhang, Ling Wei, Lonneke Haer-Wigman, Yanli Ji, C Y Mo, Y Zhao, C. Ellen van der Schoot, Guangping Luo, Zhengli Wang

Publikováno v: Blood. 124:2892-2892

Background: The RHCE allele is highly polymorphic and many variants have been described, especially in individuals of African origin. Donors carrying these variants can be falsely typed and elicit transfusion reactions, and patients carrying such a v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d93ce413de5ac5c4438ffa105173978
https://doi.org/10.1182/blood.v124.21.2892.2892