Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.

Autor: Harry F Heijnen, Richard van Wijk, Tamara C Pereboom, Yvonne J Goos, Cor W Seinen, Brigitte A van Oirschot, Rowie van Dooren, Marc Gastou, Rachel H Giles, Wouter van Solinge, Taco W Kuijpers, Hanna T Gazda, Marc B Bierings, Lydie Da Costa, Alyson W MacInnes

Publikováno v: PLoS Genetics, Vol 10, Iss 5, p e1004371 (2014)

Mutations affecting the ribosome lead to several diseases known as ribosomopathies, with phenotypes that include growth defects, cytopenia, and bone marrow failure. Diamond-Blackfan anemia (DBA), for example, is a pure red cell aplasia linked to the

Externí odkaz: https://doaj.org/article/25556d82d8954cb899e0a1e170a1ff3c

Protection of bona fide T follicular memory cells during tissue isolation reveals their persistence, plasticity and functional impact

Autor: Florian Geier, Nivedya Swarnalekha, J. T. Taylor, Carolyn G. King, Marco Künzli, Jonas Lötscher, David Schreiner, Tamara C. Pereboom, Julien Roux, Yusuf I. Ertuna, Christoph Hess

SUMMARYCD4 memory T cells play an important role in protective immunity and are a key target in vaccine development. Many studies have focused on T central memory (TCM) cells, while the existence and functional significance of T follicular helper (TF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b998ce2aac9daa0bdce8f5147a38d55c
https://doi.org/10.1101/677559

Molecular and functional interactions between AKT and SOX2 in breast carcinoma

Autor: Oliver Rothfuss, Thorsten Schaefer, Martina Konantz, Claudia Lengerke, Tamara C. Pereboom, Anna M. Paczulla, Lothar Kanz, Britta Merz, Hui Wang, Klaus Schulze-Osthoff, Perihan Mir, Tanja Fehm, Sven Perner

Publikováno v: Oncotarget

The transcription factor SOX2 is a key regulator of pluripotency in embryonic stem cells and plays important roles in early organogenesis. Recently, SOX2 expression was documented in various cancers and suggested as a cancer stem cell (CSC) marker. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b302c38394d0db55ef98ba9e038848
https://pubmed.ncbi.nlm.nih.gov/26498353

Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway

Autor: Lydie Da Costa, Tamara C. Pereboom, Wouter W. van Solinge, Marc Gastou, Taco W. Kuijpers, Rachel H. Giles, Brigitte A. van Oirschot, Hanna T. Gazda, Rowie van Dooren, Alyson W. MacInnes, Richard van Wijk, Harry F. G. Heijnen, Yvonne J. Goos, Cor W. Seinen, Marc Bierings

Publikováno v: PLoS Genetics
PLoS genetics, 10(5). Public Library of Science
PLoS Genetics, 10(5). Public Library of Science
PLoS Genetics, Vol 10, Iss 5, p e1004371 (2014)

Mutations affecting the ribosome lead to several diseases known as ribosomopathies, with phenotypes that include growth defects, cytopenia, and bone marrow failure. Diamond-Blackfan anemia (DBA), for example, is a pure red cell aplasia linked to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9711cec7bd6d9db4a8e1b40e20ac165d
https://doi.org/10.1371/journal.pgen.1004371

Perinatal exogenous nitric oxide in fawn-hooded hypertensive rats reduces renal ribosomal biogenesis in early life

Autor: Sebastiaan eWesseling, Paul B. Essers, Maarten P. Koeners, Tamara C. Pereboom, Branko eBraam, Ernst E. van Faassen, Alyson W. MacInnes, Jaap A. Joles

Publikováno v: Frontiers in Genetics
Frontiers in Genetics, 2:52. Frontiers Media SA
Frontiers in Genetics, Vol 2 (2011)

Nitric oxide (NO) is known to depress ribosome biogenesis in vitro. In this study we analyzed the influence of exogenous NO on ribosome biogenesis in vivo using a proven antihypertensive model of perinatal NO administration in genetically hypertensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52167b077619d549db89f3400439f5c
https://pubmed.ncbi.nlm.nih.gov/22303348