Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tamara A M, Mocking"'
Autor:
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A. M. Mocking, Ulrich Goldmann, Andrea Garofoli, Evert J. Homan, Alberto Di Silvio, Lucia Azzollini, Francesca Sassone, Mario Fogazza, Felix Bärenz, Antje Pommereau, Yasmin Zuschlag, Jasper F. Ooms, Jeppe Tranberg-Jensen, Jesper S. Hansen, Josefina Stanka, Hubert J. Sijben, Helena Batoulis, Eckhard Bender, Riccardo Martini, Adriaan P. IJzerman, David B. Sauer, Laura H. Heitman, Vania Manolova, Juergen Reinhardt, Alexander Ehrmann, Philipp Leippe, Gerhard F. Ecker, Kilian V. M. Huber, Thomas Licher, Lia Scarabottolo, Tabea Wiedmer, Giulio Superti-Furga
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, inc
Externí odkaz:
https://doaj.org/article/d3ca8f18dbc2476ea3722a966b570ca6
Autor:
Tamara A. M. Mocking, Wieke M. van Oostveen, Jacobus P. D. van Veldhoven, Hugo Minnee, Cynthia M. Fehres, Charles E. Whitehurst, Adriaan P. IJzerman, Laura H. Heitman
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The prostaglandin transporter (PGT, SLCO2A1) mediates transport of prostanoids (a.o. prostaglandin E2 (PGE2)) into cells and thereby promotes their degradation. Overexpression of PGT leads to low extracellular PGE2 levels and has been linked to impai
Externí odkaz:
https://doaj.org/article/e0cc08e3ad25430fb31c87cdf54e7ca2
Autor:
Xavier Gómez-Santacana, Sabrina M. de Munnik, Tamara A. M. Mocking, Niels J. Hauwert, Shanliang Sun, Prashanna Vijayachandran, Iwan J. P. de Esch, Henry F. Vischer, Maikel Wijtmans, Rob Leurs
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2509-2523 (2019)
We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3. A series of photoswitchable azobenzene
Externí odkaz:
https://doaj.org/article/191d27a959cf464cbd751133e1acc2e9
Autor:
Tamara A. M. Mocking, Hubert J. Sijben, Yimé W. Vermeulen, Adriaan P. IJzerman, Laura H. Heitman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1203 (2022)
The organic cation transporters OCT1-3 (SLC22A1-3) facilitate the transport of cationic endo- and xenobiotics and are important mediators of drug distribution and elimination. Their polyspecific nature makes OCTs highly susceptible to drug–drug int
Externí odkaz:
https://doaj.org/article/7f276ced9d5640cd90f941732da39cd9
Autor:
Gábor, Wágner, Tamara A M, Mocking, Xiaoyuan, Ma, Inna, Slynko, Daniel, Da Costa Pereira, Robin, Breeuwer, Niek J N, Rood, Cas, van der Horst, Henry F, Vischer, Chris, de Graaf, Iwan J P, de Esch, Maikel, Wijtmans, Rob, Leurs
Publikováno v:
Archiv der PharmazieREFERENCES. 356(1)
Histamine H
Autor:
Zhi Yuan, Kok, Leigh A, Stoddart, Sarah J, Mistry, Tamara A M, Mocking, Henry F, Vischer, Rob, Leurs, Stephen J, Hill, Shailesh N, Mistry, Barrie, Kellam
Publikováno v:
Journal of medicinal chemistry. 65(12)
The histamine H
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 15, p 3724 (2019)
Duration of receptor antagonism, measured as the recovery of agonist responsiveness, is gaining attention as a method to evaluate the ‘effective’ target-residence for antagonists. These functional assays might be a good alternative for kinetic bi
Externí odkaz:
https://doaj.org/article/cf53b481f374462a8a8f62afc675b1f1
Autor:
Tamara A M, Mocking, Hubert J, Sijben, Yimé W, Vermeulen, Adriaan P, IJzerman, Laura H, Heitman
Publikováno v:
International journal of molecular sciences. 23(3)
The organic cation transporters OCT1-3 (
Autor:
Sabrina M. de Munnik, Iwan J. P. de Esch, Maikel Wijtmans, Shanliang Sun, Henry F. Vischer, Niels J Hauwert, Tamara A. M. Mocking, Prashanna Vijayachandran, Xavier Gómez-Santacana, Rob Leurs
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2509-2523 (2019)
Beilstein Journal of Organic Chemistry, 15, 2509-2523. Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Gómez-Santacana, X, De Munnik, S M, Mocking, T A M, Hauwert, N J, Sun, S, Vijayachandran, P, De Esch, I J P, Vischer, H F, Wijtmans, M & Leurs, R 2019, ' A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light ', Beilstein Journal of Organic Chemistry, vol. 15, pp. 2509-2523 . https://doi.org/10.3762/bjoc.15.244
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2509-2523 (2019)
Beilstein Journal of Organic Chemistry, 15, 2509-2523. Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Gómez-Santacana, X, De Munnik, S M, Mocking, T A M, Hauwert, N J, Sun, S, Vijayachandran, P, De Esch, I J P, Vischer, H F, Wijtmans, M & Leurs, R 2019, ' A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light ', Beilstein Journal of Organic Chemistry, vol. 15, pp. 2509-2523 . https://doi.org/10.3762/bjoc.15.244
We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3. A series of photoswitchable azobenzene
Homogeneous, Real-Time NanoBRET Binding Assays for the Histamine H3 and H4 Receptors on Living Cells
Publikováno v:
Mocking, T A M, Verweij, E W E, Vischer, H F & Leurs, R 2018, ' Homogeneous, Real-Time NanoBRET Binding Assays for the Histamine H 3 and H 4 Receptors on Living Cells ', Molecular pharmacology, vol. 94, no. 6, pp. 1371-1381 . https://doi.org/10.1124/mol.118.113373
Molecular pharmacology, 94(6), 1371-1381. American Society for Pharmacology and Experimental Therapeutics
Molecular pharmacology, 94(6), 1371-1381. American Society for Pharmacology and Experimental Therapeutics
Receptor-binding affinity and ligand-receptor residence time are key parameters for the selection of drug candidates and are routinely determined using radioligand competition-binding assays. Recently, a novel bioluminescence resonance energy transfe