Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tamara, Göbel"'
Autor:
Astrid S. Kahnt, Carlo Angioni, Tamara Göbel, Bettina Hofmann, Jessica Roos, Svenja D. Steinbrink, Florian Rörsch, Dominique Thomas, Gerd Geisslinger, Kai Zacharowski, Sabine Grösch, Dieter Steinhilber, Thorsten J. Maier
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
5-Lipoxygenase (5-LO) is the key enzyme in the formation of pro-inflammatory leukotrienes (LT) which play an important role in a number of inflammatory diseases. Accordingly, 5-LO inhibitors are frequently used to study the role of 5-LO and LT in mod
Externí odkaz:
https://doaj.org/article/b2c46d5e8a6e48199733304f222f75df
Autor:
Tamara Göbel, Olaf Diehl, Jan Heering, Daniel Merk, Carlo Angioni, Sandra K. Wittmann, Estel.la Buscato, Ramona Kottke, Lilia Weizel, Tim Schader, Thorsten J. Maier, Gerd Geisslinger, Manfred Schubert-Zsilavecz, Dieter Steinhilber, Ewgenij Proschak, Astrid S. Kahnt
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cysteinyl leukotriene receptor 1 antagonists (CysLT1RA) are frequently used as add-on medication for the treatment of asthma. Recently, these compounds have shown protective effects in cardiovascular diseases. This prompted us to investigate their in
Externí odkaz:
https://doaj.org/article/a80e026f90b747f8b7674c1f676db0f4
Autor:
Marius, Kreiß, Julia H, Oberlis, Sabine, Seuter, Iris, Bischoff-Kont, Duran, Sürün, Dominique, Thomas, Tamara, Göbel, Tobias, Schmid, Olof, Rådmark, Ralf P, Brandes, Robert, Fürst, Ann-Kathrin, Häfner, Dieter, Steinhilber
Publikováno v:
Biochemical pharmacology. 203
Human 5-lipoxygenase (5-LO) is the key enzyme of leukotriene biosynthesis, mostly expressed in leukocytes and thus a crucial component of the innate immune system. In this study, we show that 5-LO, besides its canonical function as an arachidonic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3e0976a0be89ac1b7582fc9605c2abd
https://pubmed.ncbi.nlm.nih.gov/35878796
https://pubmed.ncbi.nlm.nih.gov/35878796
Autor:
Hannah Weisser, Tamara Göbel, G. Melissa Krishnathas, Marius Kreiß, Carlo Angioni, Duran Sürün, Dominique Thomas, Tobias Schmid, Ann-Kathrin Häfner, Astrid S. Kahnt
Publikováno v:
Cancer gene therapy.
5-Lipoxygenase (5-LO), the central enzyme in the biosynthesis of leukotrienes, is frequently expressed in human solid malignancies even though the enzyme is not present in the corresponding healthy tissues. There is little knowledge on the consequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c3a798e417e72043bb51c4b96f6554
https://pubmed.ncbi.nlm.nih.gov/36114329
https://pubmed.ncbi.nlm.nih.gov/36114329
Autor:
Andreas C. Joerger, Xiaomin Ni, Sebastian Mathea, Andreas Krämer, Stefan Knapp, Marek Wanior, David Heidenreich, Tamara Göbel, Svenja Simonyi, Franziska Preuss, Astrid S. Kahnt
Publikováno v:
Journal of Medicinal Chemistry. 63:14680-14699
Accessibility of the human genome is modulated by the ATP-driven SWI/SNF chromatin remodeling multiprotein complexes BAF (BRG1/BRM-associated factor) and PBAF (polybromo-associated BAF factor), which involves reading of acetylated histone tails by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c758530d93b926592134ea7ceb1e05
https://doi.org/10.1021/acs.jmedchem.0c01242
https://doi.org/10.1021/acs.jmedchem.0c01242
Autor:
Tamara Göbel, Bjarne Goebel, Marius Hyprath, Ira Lamminger, Hannah Weisser, Carlo Angioni, Marius Mathes, Dominique Thomas, Astrid S Kahnt
Publikováno v:
Life Science Alliance. 6:e202201804
The leukotriene (LT) pathway is positively correlated with the progression of solid malignancies, but the factors that control the expression of 5-lipoxygenase (5-LO), the central enzyme in LT biosynthesis, in tumors are poorly understood. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8d39c9dfb74e900c10518733a382e0
https://doi.org/10.26508/lsa.202201804
https://doi.org/10.26508/lsa.202201804
Autor:
Whitney Kilu, Ewgenij Proschak, Victor Hernandez-Olmos, Carmen Borkowsky, Astrid Kaiser, Roxane-I Kestner, Jan S. Kramer, Tamara Göbel, Sabine Willems, Stefan Knapp, Steffen Brunst, Jan Heering, Moritz Helmstädter, Dmitry Namgaladze, Xiaomin Ni, Waltraud Pfeilschifter, Mirko Brodsky, Anna Proschak, Dieter Steinhilber, Felix F Lillich, Franziska Mayser, Apirat Chaikuad, Lilia Weizel, Astrid S. Kahnt, Simone Schierle, Daniel Merk
Polypharmaceutical regimens often impair treatment of patients with metabolic syndrome (MetS), a complex disease cluster, including obesity, hypertension, heart disease, and type II diabetes. Simultaneous targeting of soluble epoxide hydrolase (sEH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7965bf06d6eedeb26c626933e27549
https://publica.fraunhofer.de/handle/publica/415873
https://publica.fraunhofer.de/handle/publica/415873
Autor:
Mario Wurglics, Ewgenij Proschak, Evi Kostenis, Christina Lamers, Markus Hartmann, Sandra K. Wittmann, Carlo Angioni, Manfred Schubert-Zsilavecz, Jan Heering, Lilia Weizel, Olaf Diehl, Astrid S. Kahnt, Manuel Grundmann, Tamara Göbel, Astrid Brüggerhoff, René Blöcher, Gerd Geisslinger, Dieter Steinhilber, Daniel Merk, Astrid Kaiser, Bernhard Brüne, Marcel Boß, Tim Schader
Publikováno v:
Journal of Medicinal Chemistry. 59:61-81
Metabolic syndrome (MetS) is a multifactorial disease cluster that consists of dyslipidemia, cardiovascular disease, type 2 diabetes mellitus, and obesity. MetS patients are strongly exposed to polypharmacy; however, the number of pharmacological com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae556f64565e7402baab643884a823e
https://doi.org/10.1021/acs.jmedchem.5b01239
https://doi.org/10.1021/acs.jmedchem.5b01239