Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Tamar Uziel"'
Autor:
Erwin R. Boghaert, Xin Lu, Paul E. Hessler, Thomas P. McGonigal, Anatol Oleksijew, Michael J. Mitten, Kelly Foster-Duke, Jonathan A. Hickson, Vitor E. Santo, Catarina Brito, Tamar Uziel, Kedar S. Vaidya
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 9, Pp 695-706 (2017)
Improving the congruity of preclinical models with cancer as it is manifested in humans is a potential way to mitigate the high attrition rate of new cancer therapies in the clinic. In this regard, three-dimensional (3D) tumor cultures in vitro have
Externí odkaz:
https://doaj.org/article/6657b2f38afc4560b02a1a64b41eee38
Autor:
Stephen K. Tahir, Emiliano Calvo, Benedito A. Carneiro, Junichiro Yuda, Aditya Shreenivas, Mojca Jongen-Lavrencic, Eelke Gort, Kenichi Ishizawa, Daniel Morillo, Carla Biesdorf, Morey Smith, Dong Cheng, Monica Motwani, David Sharon, Tamar Uziel, Dimple A. Modi, Fritz G. Buchanan, Susan Morgan-Lappe, Bruno C. Medeiros, Darren C. Phillips
Publikováno v:
Blood, 141(17), 2114-2126. American Society of Hematology
Activation of apoptosis in malignant cells is an established strategy for controlling cancer and is potentially curative. To assess the impact of concurrently inducing the extrinsic and intrinsic apoptosis-signaling pathways in acute myeloid leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298281c9a9769a2760e6484a88646b4
https://doi.org/10.1182/blood.2022017333
https://doi.org/10.1182/blood.2022017333
Autor:
Yu Shen, Marina Konopleva, Warren M. Kati, Keith F. McDaniel, Daniel H. Albert, Michael Boyiadzis, Kathleen A. Dorritie, Neal C. Goodwin, Jenny Rowe, Terrance J. Magoc, Sriram S. Shanmugavelandy, Gaurav Mehta, Debra C. Ferguson, Lina Han, Antonio Cavazos, Qi Zhang, Tamar Uziel, Paul Hessler, Weiguo Feng, Zheng Zha, Xin Lu, Lloyd T. Lam, Vinitha M. Kuruvilla, Emily J. Faivre, Richard J. Bellin, Joshua P. Plotnik, Mai H. Bui, Xiaoli Huang, Xiaoyu Lin, Tianyu Cai, Lu Zhang
Figure S1.ABBV-744 exhibits potent anti-proliferative activity against AML cells through cell cycle arrest and induction of apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28636d93afc4aab3fada0dae41d1a617
https://doi.org/10.1158/1535-7163.22521676.v1
https://doi.org/10.1158/1535-7163.22521676.v1
Autor:
Yu Shen, Marina Konopleva, Warren M. Kati, Keith F. McDaniel, Daniel H. Albert, Michael Boyiadzis, Kathleen A. Dorritie, Neal C. Goodwin, Jenny Rowe, Terrance J. Magoc, Sriram S. Shanmugavelandy, Gaurav Mehta, Debra C. Ferguson, Lina Han, Antonio Cavazos, Qi Zhang, Tamar Uziel, Paul Hessler, Weiguo Feng, Zheng Zha, Xin Lu, Lloyd T. Lam, Vinitha M. Kuruvilla, Emily J. Faivre, Richard J. Bellin, Joshua P. Plotnik, Mai H. Bui, Xiaoli Huang, Xiaoyu Lin, Tianyu Cai, Lu Zhang
Primary patient sample information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282ab3dc5a5370970baa604506670681
https://doi.org/10.1158/1535-7163.22521655.v1
https://doi.org/10.1158/1535-7163.22521655.v1
Autor:
Tamar Uziel, Yu Shen, Daniel H. Albert, Warren M. Kati, Anahita Bhathena, Terry Magoc, Michael Mitten, Stephen K. Tahir, Sha Jin, Richard J. Bellin, Denise M. Wilcox, Xiaoli Huang, Ziping Yang, Emily J. Faivre, Xiaoyu Lin, Lloyd T. Lam
Suppl. Figure 1. Caspase inhibitor prevents caspase 3/7 activity; Suppl. Figure 2. Levels of BIM, BAD, BAX and BAK silencing by siRNA; Suppl. Figure 3. mRNA and protein expression of BCL2 and BCLxl upon treatment with ABBV-075.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1dad5db1a75487ec658a49fed01fd1
https://doi.org/10.1158/1535-7163.22508502.v1
https://doi.org/10.1158/1535-7163.22508502.v1
Autor:
Yu Shen, Marina Konopleva, Warren M. Kati, Keith F. McDaniel, Daniel H. Albert, Michael Boyiadzis, Kathleen A. Dorritie, Neal C. Goodwin, Jenny Rowe, Terrance J. Magoc, Sriram S. Shanmugavelandy, Gaurav Mehta, Debra C. Ferguson, Lina Han, Antonio Cavazos, Qi Zhang, Tamar Uziel, Paul Hessler, Weiguo Feng, Zheng Zha, Xin Lu, Lloyd T. Lam, Vinitha M. Kuruvilla, Emily J. Faivre, Richard J. Bellin, Joshua P. Plotnik, Mai H. Bui, Xiaoli Huang, Xiaoyu Lin, Tianyu Cai, Lu Zhang
Supplementary figure and table legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92caa8459e59b7bf1287845739d1ee4a
https://doi.org/10.1158/1535-7163.22521658.v1
https://doi.org/10.1158/1535-7163.22521658.v1
Autor:
Lloyd T. Lam, Tamar Uziel, Albert Lai, Anahita Bhathena, Xin Lu, Loren M. Lasko, Paul Hessler, Ziping Yang, Valerie Robinson, Yupeng He, Rui Wang
Suppl. Figure 1. Dependency of human melanoma cell lines on MITF; Suppl. Figure 2. A-485 treatment reduces viability of primary melanoma cell line; Suppl. Figure 3. A-485 treatment does not induce apoptosis in melanoma cells; Suppl. Figure 4. A-485 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4893114708294b09d49142360430b3e9
https://doi.org/10.1158/1535-7163.22504405
https://doi.org/10.1158/1535-7163.22504405
Autor:
Yu Shen, Warren Kati, Keith McDaniel, Daniel H. Albert, Tamar Uziel, Wei He, Maricel Torrent, Paul Hessler, Xiaoyu Lin, Denise Wilcox, Emily J. Faivre
AR-dependent prostate cancer cell lines are dependent on BET.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f111a5f29806b02929fb08eb34526e
https://doi.org/10.1158/1541-7786.22517328.v1
https://doi.org/10.1158/1541-7786.22517328.v1
Autor:
Yu Shen, Marina Konopleva, Warren M. Kati, Keith F. McDaniel, Daniel H. Albert, Michael Boyiadzis, Kathleen A. Dorritie, Neal C. Goodwin, Jenny Rowe, Terrance J. Magoc, Sriram S. Shanmugavelandy, Gaurav Mehta, Debra C. Ferguson, Lina Han, Antonio Cavazos, Qi Zhang, Tamar Uziel, Paul Hessler, Weiguo Feng, Zheng Zha, Xin Lu, Lloyd T. Lam, Vinitha M. Kuruvilla, Emily J. Faivre, Richard J. Bellin, Joshua P. Plotnik, Mai H. Bui, Xiaoli Huang, Xiaoyu Lin, Tianyu Cai, Lu Zhang
Dual bromodomain BET inhibitors that bind with similar affinities to the first and second bromodomains across BRD2, BRD3, BRD4, and BRDT have displayed modest activity as monotherapy in clinical trials. Thrombocytopenia, closely followed by symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d00f3fe37fd40d5b4caa87153f1a3bc
https://doi.org/10.1158/1535-7163.c.6543097.v1
https://doi.org/10.1158/1535-7163.c.6543097.v1
Autor:
Tamar Uziel, William N. Pappano, Cherrie Donawho, Joel D. Leverson, Keith M. Hamel, Ahmed Hamed Salem, Anahita Bhathena, Mark Merchant, Aparna Raval, Deepak Sampath, Christine J. Orr, Yijin Li, An D. Do, Valerie A. Robinson, Jacob J. Riehm, Nimita Dave, Yan Shi, Elisabeth A. Lasater, Rui Wang, Paul A. Ellis, Ryan Duggan, Rebecca Mathew, Dipica Haribhai, Frederick J. Kohlhapp
Supplementary Figures S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704a1bb80d5836350d691acabb9a1130
https://doi.org/10.1158/2159-8290.22536893
https://doi.org/10.1158/2159-8290.22536893