Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Tamar Sapir"'
Autor:
Aditya Kshirsagar, Svetlana Maslov Doroshev, Anna Gorelik, Tsviya Olender, Tamar Sapir, Daisuke Tsuboi, Irit Rosenhek-Goldian, Sergey Malitsky, Maxim Itkin, Amir Argoetti, Yael Mandel-Gutfreund, Sidney R. Cohen, Jacob H. Hanna, Igor Ulitsky, Kozo Kaibuchi, Orly Reiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and
Externí odkaz:
https://doaj.org/article/8c6fab3847b84597928e2c033a4023c9
Autor:
Tamar Sapir, Aditya Kshirsagar, Anna Gorelik, Tsviya Olender, Ziv Porat, Ingrid E. Scheffer, David B. Goldstein, Orrin Devinsky, Orly Reiner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
HNRNPU is an RNA splicing protein associated with brain disorders such as early onset seizures. Here they show that HNRNPU functions to maintain neural progenitors and their progeny by regulating splicing of key neuronal genes.
Externí odkaz:
https://doaj.org/article/b79fbbfd33ea4996851afbb74dc44821
Autor:
Andrew K. Ressler, Gabriela L.A. Sampaio, Sarah A. Dugger, Tamar Sapir, Daniel Krizay, Michael J. Boland, Orly Reiner, David B. Goldstein
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105797- (2023)
Summary: Generating effective therapies for neurodevelopmental disorders has remained elusive. An emerging drug discovery approach for neurodevelopmental disorders is to characterize transcriptome-wide dysregulation in an appropriate model system and
Externí odkaz:
https://doaj.org/article/17f56316ef2941a387579a5f6eaab3e1
Autor:
Jordan Axelrad, Millie Long, Sara Horst, Anita Afzali, Tamar Sapir, Kristina Fajardo, Kara De Felice, Robert Sandler, Raymond Cross
Publikováno v:
JMIR Research Protocols, Vol 11, Iss 12, p e40382 (2022)
BackgroundInflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract. Although adherence to IBD therapies is associated with improved clinical outcomes, overall adherence is poor. Consequently, there is a cri
Externí odkaz:
https://doaj.org/article/cb0a5a3986834fd7b06328230af70b96
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Kinsley Belle, Tamar Sapir, Fanuel Messaggio, Kevin B. Johnson, Oliver Umland, Darrell Hardin, Dagmar Klein, Ingrid Pérez-Álvarez, Fatima Sadiq, Oscar Alcázar, Luca A. Inverardi, Camillo Ricordi, Peter Buchwald, Christopher A. Fraker, Ricardo L. Pastori, Juan Domínguez-Bendala
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 611-623 (2019)
Summary: The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment of diabetes is finally approaching the clinical stage. However, even with state-of-the-art differentiation protocols, a significant
Externí odkaz:
https://doaj.org/article/4370bf27b2c441a0890f656127747865
Publikováno v:
Cells, Vol 11, Iss 10, p 1642 (2022)
The cortex is a highly organized structure that develops from the caudal regions of the segmented neural tube. Its spatial organization sets the stage for future functional arealization. Here, we suggest using a developmental perspective to describe
Externí odkaz:
https://doaj.org/article/2bb51416c1634782879a56e11dc80816
Autor:
Anna Gorelik, Tamar Sapir, Rebecca Haffner-Krausz, Tsviya Olender, Trent M. Woodruff, Orly Reiner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Emerging evidence suggests that immune molecules play an important role in regulating brain development. Goreliket al. show that molecules in the lectin arm of the complement pathway are expressed in the developing mouse cortex, and regulate radial m
Externí odkaz:
https://doaj.org/article/e11dc61947534819a52c2923baf9b313
Autor:
Tamar Sapir, Tahsin Stefan Barakat, Mercedes F. Paredes, Tally Lerman-Sagie, Eleonora Aronica, Wlodzimierz Klonowski, Laurent Nguyen, Bruria Ben Zeev, Nadia Bahi-Buisson, Richard Leventer, Noa Rachmian, Orly Reiner
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
In the middle of March 2019, a group of scientists and clinicians (as well as those who wear both hats) gathered in the green campus of the Weizmann Institute of Science to share recent scientific findings, to establish collaborations, and to discuss
Externí odkaz:
https://doaj.org/article/1ba1868be3f9485ca317ae4fd8cd5c6c
Autor:
Tamar Sapir, Michal Segal, Gayane Grigoryan, Karin M. Hansson, Peter James, Menahem Segal, Orly Reiner
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the curre
Externí odkaz:
https://doaj.org/article/6eeddc2e21c24a2f98153361ea4cc5a7
Autor:
Susana M Chan, Tamar Sapir, Sung-Soo Park, Jean-François Rual, Rafael Contreras-Galindo, Orly Reiner, David M Markovitz
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212970 (2019)
Human endogenous retroviruses are remnants of ancient germline infections that make up approximately 8% of the modern human genome. The HERV-K (HML-2) family is one of the most recent entrants into the human germline, these viruses appear to be trans
Externí odkaz:
https://doaj.org/article/1ce94090caf74aac93896172cbee83c5