Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Taman Mahdi"'
Autor:
Pawel Buda, Thomas Reinbothe, Vini Nagaraj, Taman Mahdi, Cheng Luan, Yunzhao Tang, Annika S Axelsson, Daiqing Li, Anders H Rosengren, Erik Renström, Enming Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64462 (2013)
Inappropriate surface expression of voltage-gated Ca(2+)channels (CaV) in pancreatic ß-cells may contribute to the development of type 2 diabetes. First, failure to increase intracellular Ca(2+) concentrations at the sites of exocytosis impedes insu
Externí odkaz:
https://doaj.org/article/e97aee6f6f524de79c6ef2eb8a3795a9
Autor:
James D. Johnson, Thomas Reinbothe, Joshua Millstein, Anna Wendt, Sonja Hänzelmann, Sofia Salö, Jinling Wang, Malin Fex, Hindrik Mulder, Annika Bagge, Taman Mahdi, B Mecham, Xia Yang, Anders Rosengren, Tania Singh, Peter Spégel, Ivan G. Costa, Eduardo G. Gusmao, Jonathan M. J. Derry, Enming Zhang, Claes B. Wollheim, Lena Eliasson, Bin Zhang, Le Shu, Isabella Artner, Annika S. Axelsson, M Szabat, Hannah Nenonen, Yunzhao Tang
Publikováno v:
Nature Communications, Vol. 8 (2017) P. 15652
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications 8, 15652 (2017). doi:10.1038/ncomms15652
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications 8, 15652 (2017). doi:10.1038/ncomms15652
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7bea2c4c995c64a58f986b5f944ebe
https://pubmed.ncbi.nlm.nih.gov/28643804
https://pubmed.ncbi.nlm.nih.gov/28643804
Autor:
Vini Nagaraj, Taman Mahdi, Daiqing Li, Pawel Buda, Yunzhao Tang, Thomas Reinbothe, Enming Zhang, Erik Renström, Annika S. Axelsson, Anders Rosengren, Cheng Luan
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64462 (2013)
PLoS ONE; 8(5), no e64462 (2013)
PLoS ONE
PLoS ONE; 8(5), no e64462 (2013)
PLoS ONE
Inappropriate surface expression of voltage-gated Ca(2+)channels (CaV) in pancreatic ß-cells may contribute to the development of type 2 diabetes. First, failure to increase intracellular Ca(2+) concentrations at the sites of exocytosis impedes insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c5e46750474c493a0eff2c6fcd1eee
http://europepmc.org/articles/PMC3667822?pdf=render
http://europepmc.org/articles/PMC3667822?pdf=render
Autor:
Yunzhao Tang, Ola Hansson, Thomas Reinbothe, Taman Mahdi, Yuedan Zhou, Jonathan M. J. Derry, Valeriya Lyssenko, Jalal Taneera, Leif Groop, Claes B. Wollheim, Xingjun Jing, Albert Salehi, Lena Eliasson, Ulrika Krus, Jonathan L.S. Esguerra, Peter Almgren, Anders Rosengren, Enming Zhang, Erik Renström, Sonja Hänzelmann, Sarheed Jabar Muhammed, Anna M. Blom, Annika S. Axelsson
Publikováno v:
Cell Metabolism, Vol. 16, No 5 (2012) pp. 625-33
Cell Metabolism; 16(5), pp 625-633 (2012)
Cell Metabolism; 16(5), pp 625-633 (2012)
SummaryA plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126bd5ad8c16d23d81421a3a35eabee6
http://lup.lub.lu.se/record/3219063/file/3878932.pdf
http://lup.lub.lu.se/record/3219063/file/3878932.pdf
Autor:
Sofia A Andersson, Makoto Shigeto, Patrik Rorsman, Matthias Braun, Leif Groop, Paul Johnson, Enming Zhang, Erik Renström, Amy Barrett, Peter Almgren, Yunzhao Tang, Annika S. Axelsson, Taman Mahdi, Anders Rosengren, Anna Jonsson, Claes Ladenvall, Lena Eliasson, Mary E. Travers, Valeriya Lyssenko, Albert Salehi, Jonathan N. Walker, Morten Gram Pedersen, Mark I. McCarthy, Anna Edlund, Reshma Ramracheya, Anna L. Gloyn
Publikováno v:
Diabetes
The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0222dc0eb4290c282a4cbf59f057be8
http://hdl.handle.net/11577/2523707
http://hdl.handle.net/11577/2523707
Publikováno v:
Biophysical Journal. 98:695a
BackgroundL-type Calcium channels evoke insulin secretion, and are particularly important for an initial rapid burst of hormone secretion in both rodents and human. The magnitude of this secretory burst depends on the number of Cav1.2 in plasma membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f917f1ac002b32529d19191b69d86f9e
https://doi.org/10.1016/j.bpj.2009.12.3815
https://doi.org/10.1016/j.bpj.2009.12.3815