Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Tamaki Suganuma"'
Autor:
Tamaki Suganuma, Jerry L. Workman
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and compaction of chromatin preserves energy. Alteration of chromatin structure uses energy source
Externí odkaz:
https://doaj.org/article/bd107260f30f4f38a81290c7d97be8f9
Autor:
Tamaki Suganuma, Jerry L. Workman
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102270- (2022)
Overproduction of reactive oxygen species (ROS) drives inflammation and mutagenesis. However, the role of the DNA damage response in immune responses remains largely unknown. Here we found that stabilization of the mismatch repair (MMR) protein MSH6
Externí odkaz:
https://doaj.org/article/5a8b8ed586ea4b59bd90a888444ae5a5
Autor:
Tamaki Suganuma, Jerry L. Workman
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The mechanisms of epigenetic gene regulation—histone modifications, chromatin remodeling, DNA methylation, and noncoding RNA—use metabolites as enzymatic cofactors and substrates in reactions that allow chromatin formation, nucleotide biogenesis,
Externí odkaz:
https://doaj.org/article/8ff192bb6e8742c7985de3afd11436c2
Autor:
Tamaki Suganuma
Publikováno v:
Molecules, Vol 27, Iss 12, p 3733 (2022)
Molybdenum cofactor (Moco) biosynthesis requires iron, copper, and ATP. The Moco-containing enzyme sulfite oxidase catalyzes terminal oxidation in oxidative cysteine catabolism, and another Moco-containing enzyme, xanthine dehydrogenase, functions in
Externí odkaz:
https://doaj.org/article/3bda0907155340a685cdb63143d21bb3
Autor:
Tamaki Suganuma, Selene K. Swanson, Madelaine Gogol, Timothy J. Garrett, Juliana Conkright-Fincham, Laurence Florens, Michael P. Washburn, Jerry L. Workman
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1585-1596 (2018)
Summary: Metabolic disorder has been suggested to underlie Alzheimer’s disease (AD). However, the decisive molecular linkages remain unclear. We discovered that human Molybdopterin Synthase Associating Complex, MPTAC, promotes sulfur amino acid cat
Externí odkaz:
https://doaj.org/article/452621fa20c943dd80d9338e790b6eb3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10274 (2021)
Inflammation is the body’s means of defense against harmful stimuli, with the ultimate aim being to restore homeostasis. Controlled acute inflammation transiently activates an immune response and can be beneficial as protection against infection or
Externí odkaz:
https://doaj.org/article/ce7305745018460c891f68e745ea50d5
Publikováno v:
eLife, Vol 7 (2018)
Upon nutritional stress, the metabolic status of cells is changed by nutrient signaling pathways to ensure survival. Altered metabolism by nutrient signaling pathways has been suggested to influence cellular lifespan. However, it remains unclear how
Externí odkaz:
https://doaj.org/article/c438fff8aa7f4d2f84160aef11323ac5
Autor:
Jerry L. Workman, Tamaki Suganuma
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology
Frontiers in Endocrinology
The mechanisms of epigenetic gene regulation—histone modifications, chromatin remodeling, DNA methylation, and noncoding RNA—use metabolites as enzymatic cofactors and substrates in reactions that allow chromatin formation, nucleotide biogenesis,
Autor:
Selene K. Swanson, Jerry L. Workman, Timothy J. Garrett, Tamaki Suganuma, Madelaine Gogol, Laurence Florens
Publikováno v:
J Mol Cell Biol
Autor:
Tamaki Suganuma, Jerry L. Workman
Publikováno v:
Annual Review of Biochemistry. 87:27-49
Chromatin is a mighty consumer of cellular energy generated by metabolism. Metabolic status is efficiently coordinated with transcription and translation, which also feed back to regulate metabolism. Conversely, suppression of energy utilization by c