Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tamaki Muramoto"'
Autor:
Yoshihisa Shimizu, Takashi Yokoyama, Tetsuyuki Kitamoto, Shirou Mohri, Yoshifumi Iwamaru, Tamaki Muramoto, Yuichi Tagawa, Yuko Kaku-Ushiki
Publikováno v:
Microbiology and Immunology. 54:112-121
mAbs T1 and T2 were established by immunizing PrP gene ablated mice with recombinant MoPrP of residues 121-231. Both mAbs were cross-reactive with PrP from hamster, sheep, cattle and deer. A linear epitope of mAb T1 was identified at residues 137-143
Publikováno v:
The American Journal of Pathology. 163:2585-2593
Mice to which human prions efficiently transmit in short incubation periods are valuable not only as research tools of human prions but also as reliable diagnostic tools. We recently produced a line of knock-in mouse expressing a unique human-mouse c
Autor:
Chikao Yutani, Tamaki Muramoto, Noritoshi Kitamoto, Tomoyuki Tanaka, Yushi Hayashi, Tetsuyuki Kitamoto, Chiharu Sano, Tomoko Kutomi
Publikováno v:
Neuroscience Letters. 288:179-182
Two monoclonal antibodies that specifically detect human prion protein (PrP) were developed. The epitope of both antibodies was mapped using fusion proteins of glutathione-S-transferase and PrP peptides to the C-terminal region encompassing the polym
Autor:
Jun Higuchi, Harunobu Murayama, Tamaki Muramoto, Satoshi Shibuya, Ryong-Woon Shin, Tetsuyuki Kitamoto
Publikováno v:
The American Journal of Pathology. 155:877-885
To demonstrate that aluminum III (Al) interacts with PHFtau in neurofibrillary degeneration (NFD) of Alzheimer's disease (AD) brain, we developed a "chelating autoclave method" that allows Al chelation by using trivalent-cationic chelator desferrioxa
Autor:
Patrick J. Bosque, Fred E. Cohen, Stephen J. DeArmond, Cornelia Heinrich, Stanley B. Prusiner, Hoang Oanh B Nguyen, David Peretz, Surachai Supattapone, Tamaki Muramoto, Holger Wille, Claus Aagaard, Jiri G. Safar, Michael R. Scott, Marilyn Torchia
Publikováno v:
Cell. 96(6):869-878
A redacted prion protein (PrP) of 106 amino acids with two large deletions was expressed in transgenic (Tg) mice deficient for wild-type (wt) PrP (Prnp0/0) and supported prion propagation. RML prions containing full-length PrP(Sc)produced disease in
Publikováno v:
Acta Neuropathologica. 92:441-446
We describe the clinical, neuropathological, immunohistochemical and transmission findings in three patients with Creutzfeldt-Jakob disease (CJD) with a substitution from methionine to arginine at codon 232 (M232R) in the prion protein (PrP) gene. Th
Autor:
Tamaki, Muramoto
Publikováno v:
Rinsho shinkeigaku = Clinical neurology. 43(11)
In order to explore the structural domains of prion protein (PrP) that are required for the isoform conversion, prion formation and neurodegenerative effects, we designed a series of PrP deletion mutants and studied, using prion-infected cultured cel
Publikováno v:
Nihon rinsho. Japanese journal of clinical medicine.
Autor:
Tomoyuki Tanaka, Takeshi Sato, Noritoshi Kitamoto, Shirou Mohri, James W. Ironside, Tetsuyuki Kitamoto, Kazuo Nagashima, Tamaki Muramoto, Katsuya Satoh, Masahito Yamada
Publikováno v:
The Journal of general virology. 84(Pt 10)
Creutzfeldt–Jakob disease can develop in subjects given a cadaveric dura mater graft (dCJD). This disease has a phenotypic heterogeneity despite the lack of genetic variation. Numerous plaque-type prion protein (PrP) deposits are found in the brain
Autor:
Motoya Katsuki, James W. Ironside, Ichiro Miyoshi, Tomoyuki Tanaka, Jun Higuchi, Tetsuyuki Kitamoto, Noriyuki Kasai, Tamaki Muramoto, Ryong Woon Shin, Shigeyoshi Itohara, Noritoshi Kitamoto, Shirou Mohri
Publikováno v:
Biochemical and biophysical research communications. 294(2)
Infectious prion diseases initiate infection within lymphoid organs where prion infectivity accumulates during the early stages of peripheral infection. In a mouse-adapted prion infection, an abnormal isoform (PrP(Sc)) of prion protein (PrP) accumula