Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948.

Autor: Filipski KJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Martinez-Alsina LA; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Reese MR; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Evrard E; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Buzon LM; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Cameron KO; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Zhang Y; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Coffman KJ; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Bradow J; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Kormos BL; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Liu S; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Knafels JD; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Sahasrabudhe PV; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Chen J; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Bessire AJ; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Orozco CC; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Balesano A; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Cerny MA; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Bollinger E; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Reyes AR; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Laforest B; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Rosado A; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Williams G; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Marshall M; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Tam Neale K; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Chen X; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Hirenallur-Shanthappa D; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Stansfield JC; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Groarke J; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Qiu R; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Karas S; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Roth Flach RJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Esler WP; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.