Výsledky vyhledávání - "Tam L. Nguyen"

Akademický článek

Strategies to Overcome Biological Barriers Associated with Pulmonary Drug Delivery

Autor: Adam J. Plaunt, Tam L. Nguyen, Michel R. Corboz, Vladimir S. Malinin, David C. Cipolla

Publikováno v: Pharmaceutics, Vol 14, Iss 2, p 302 (2022)

While the inhalation route has been used for millennia for pharmacologic effect, the biological barriers to treating lung disease created real challenges for the pharmaceutical industry until sophisticated device and formulation technologies emerged

Externí odkaz: https://doaj.org/article/caf4b876b6df4a879758e69fa018fc83

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Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions

Autor: Tam L. Nguyen, Carrie E. Perlman

Publikováno v: J Appl Physiol (1985)

In the acute respiratory distress syndrome (ARDS), alveolar surface tension,T, may be elevated. ElevatedTshould increase ventilation-induced lung injury. Exogenous surfactant therapy, intended to lowerT, has not reduced mortality. Sulforhodamine B (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36249f36934e7e0fc0f8d80e806cb222
https://doi.org/10.1101/2020.04.08.031526

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Tracheal acid or surfactant instillation raises alveolar surface tension

Autor: Tam L. Nguyen, Carrie E. Perlman

Publikováno v: Journal of Applied Physiology. 125:1357-1367

Whether alveolar liquid surface tension, T, is elevated in the acute respiratory distress syndrome (ARDS) has not been demonstrated in situ in the lungs. Neither is it known how exogenous surfactant, which has failed to treat ARDS, affects in situ T.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2786793522e389dbff19c6a95d86b645
https://doi.org/10.1152/japplphysiol.00397.2017

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Prognostic utility of inflammation biomarkers in a PDAC trial involving the human anti-CTGF antibody pamrevlumab

Autor: Mairead Carney, Mark D. Sternlicht, Dongxia Li, Todd W. Seeley, Elias Kouchakji, Kenneth E. Lipson, Viet-Tam L. Nguyen, Ewa Carrier, Vincent J. Picozzi, Duo Zhou

Publikováno v: Journal of Clinical Oncology. 38:752-752

752 Background: Pancreatic ductal adenocarcinomas (PDAC) often exhibit desmoplasia, elevated CTGF (connective tissue growth factor) expression and inflammation. The influence of inflammation on patient outcomes was examined in a dose-ranging trial of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8e7cba0ef1441b1fd5ba978053c5a4d
https://doi.org/10.1200/jco.2020.38.4_suppl.752

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Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps

Autor: Randolph H. Stewart, Glen A. Laine, Emily Wilson, Ranjeet M. Dongaonkar, Tam L. Nguyen, Cristine L. Heaps, Christopher M. Quick, Joanne Hardy

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 308:R391-R399

Lymphangions, the segments of lymphatic vessels between two adjacent lymphatic valves, actively pump lymph. Acute changes in transmural pressure and lymph flow have profound effects on lymphatic pump function in vitro. Chronic changes in pressure and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96057cfab12d4b906e44302349f87a5f
https://doi.org/10.1152/ajpregu.00196.2014

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Accelerated deflation promotes homogeneous airspace liquid distribution in the edematous lung

Autor: You Wu, Tam L. Nguyen, Carrie E. Perlman

Edematous lungs contain regions with heterogeneous alveolar flooding. Liquid is trapped in flooded alveoli by a pressure barrier—higher liquid pressure at the border than in the center of flooded alveoli—that is proportional to surface tension, T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ba1c2d85065741a73734a633eba528
https://europepmc.org/articles/PMC5407205/

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Modulation of Dimerization, Binding, Stability, and Folding by Mutation of the Neurophysin Subunit Interface

Autor: Esther Breslow, Tam L. Nguyen, David Peyton, Sharon Eubanks

Publikováno v: Biochemistry. 39:8085-8094

Bovine neurophysins, which have typically served as the paradigm for neurophysin behavior, are metastable in their disulfide-paired folded state and require ligand stabilization for efficient folding from the reduced state. Studies of unliganded porc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4f2e97c69b5293c189917210cd4152
https://doi.org/10.1021/bi0001527

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Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure

Autor: Christopher M. Quick, Tam L. Nguyen, Emily Wilson, Joanne Hardy, Glen A. Laine, Randolph H. Stewart, Ranjeet M. Dongaonkar

Publikováno v: American journal of physiology. Heart and circulatory physiology. 305(2)

In vitro studies have revealed that acute increases in transmural pressure increase lymphatic vessel contractile function. However, adaptive responses to prolonged changes in transmural pressure in vivo have not been reported. Therefore, we developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1c29c1264b8066eea6c94406a389e5
https://pubmed.ncbi.nlm.nih.gov/23666672

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