Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Tamás Hegedus"'
Publikováno v:
Energies, Vol 14, Iss 21, p 7438 (2021)
In this paper, a novel neural network-based robust control method is presented for a vehicle-oriented problem, in which the main goal is to ensure stable motion of the vehicle under critical circumstances. The proposed method can be divided into two
Externí odkaz:
https://doaj.org/article/55abd812283943cab89d2a4bf439e01c
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 2, p e1000008 (2008)
The absence of a functional ATP Binding Cassette (ABC) protein called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) from apical membranes of epithelial cells is responsible for cystic fibrosis (CF). Over 90% of CF patients carry at l
Externí odkaz:
https://doaj.org/article/47dbca58aef04f2e950b2187c798b625
Autor:
Blanka Berta, Hedvig Tordai, Gergely L. Lukács, Béla Papp, Ágnes Enyedi, Rita Padányi, Tamás Hegedűs
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The clinical management of severe COVID-19 cases is not yet well resolved. Therefore, it is important to identify and characterize cell signaling pathways involved in virus pathogenesis that can be targeted therapeutically. Envelope (E) prot
Externí odkaz:
https://doaj.org/article/b1a35e72b7564ce294fa597e41590c61
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Single amino acid substitutions can profoundly affect protein folding, dynamics, and function. The ability to discern between benign and pathogenic substitutions is pivotal for therapeutic interventions and research directions. Given the lim
Externí odkaz:
https://doaj.org/article/ebdfafeb85e240558d1f013b266f21f4
Transmembrane (TM) proteins are major drug targets, indicated by the high percentage of prescription drugs acting on them. For a rational drug design and an understanding of mutational effects on protein function, structural data at atomic resolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56629ac407633c0a189c0cb3a3b856ae
https://doi.org/10.1101/2021.08.21.457196
https://doi.org/10.1101/2021.08.21.457196
Autor:
Hedvig Tordai, Rita Padányi, Bianka Farkas, Bálint Kiss, Helmut Grubmüller, Miklós S.Z. Kellermayer, Gergely L. Lukacs, Tamás Hegedus, Naoto Soya
Cystic fibrosis is most frequently caused by the deletion of F508 (ΔF508) in CFTR’s nucleotide binding domain 1 (NBD1), compromising CFTR folding, stability and domain assembly. The limitation of developing a successful therapy is due to the lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4fe9ae08d5af612f9a7275a3df65ce1
https://doi.org/10.1101/2021.08.20.457065
https://doi.org/10.1101/2021.08.20.457065
Autor:
Naoto Soya, Haijin Xu, Ariel Roldan, Zhengrong Yang, Haoxin Ye, Fan Jiang, Aiswarya Premchandar, Guido Veit, Susan P. C. Cole, John Kappes, Tamás Hegedüs, Gergely L. Lukacs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide bind
Externí odkaz:
https://doaj.org/article/26ee4a0b5ae048ff8a59c8ecf53a2afc
Autor:
Ahmad Al-Hassiny, Dániel Végh, Dorottya Bányai, Ádám Végh, Zoltán Géczi, Judit Borbély, Péter Hermann, Tamás Hegedüs
Publikováno v:
International Dental Journal, Vol 73, Iss 5, Pp 754-759 (2023)
ABSTRACT: Introduction: Intraoral scanners (IOS) are continuing to gain popularity in clinical dentistry, replacing the traditional impression-taking and related technology. Despite their increasing importance, there are few data on the utility and u
Externí odkaz:
https://doaj.org/article/a61aa3a30bf5470abe031f8588ae9f59
Autor:
András Málnási-Csizmadia, Tamás Hegedus, Agnes K. Mike, Mátyás C. Földi, K. Pesti, Katalin Zboray, Peter Lukacs
Sodium channel inhibitor drugs can exert their effect by either blocking, or modulating the channel. The extent of modulation versus channel block is crucial regarding the therapeutic potential of drug candidates. Modulation can be selective for path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facbf78674e1182470cf5da78b924dbc
Autor:
Anna Brózik, Kinga András, Hedvig Tordai, Tamás Hegedus, Balázs Sarkadi, Gergely Gyimesi, Kristóf Jakab
Publikováno v:
Database: The Journal of Biological Databases and Curation
ABC (ATP-Binding Cassette) proteins with altered function are responsible for numerous human diseases. To aid the selection of positions and amino acids for ABC structure/function studies we have generated a database, ABCMdb (Gyimesi et al., ABCMdb: