Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Tamás Hegedus"'
Publikováno v:
Energies, Vol 14, Iss 21, p 7438 (2021)
In this paper, a novel neural network-based robust control method is presented for a vehicle-oriented problem, in which the main goal is to ensure stable motion of the vehicle under critical circumstances. The proposed method can be divided into two
Externí odkaz:
https://doaj.org/article/55abd812283943cab89d2a4bf439e01c
Transmembrane (TM) proteins are major drug targets, indicated by the high percentage of prescription drugs acting on them. For a rational drug design and an understanding of mutational effects on protein function, structural data at atomic resolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56629ac407633c0a189c0cb3a3b856ae
https://doi.org/10.1101/2021.08.21.457196
https://doi.org/10.1101/2021.08.21.457196
Autor:
Hedvig Tordai, Rita Padányi, Bianka Farkas, Bálint Kiss, Helmut Grubmüller, Miklós S.Z. Kellermayer, Gergely L. Lukacs, Tamás Hegedus, Naoto Soya
Cystic fibrosis is most frequently caused by the deletion of F508 (ΔF508) in CFTR’s nucleotide binding domain 1 (NBD1), compromising CFTR folding, stability and domain assembly. The limitation of developing a successful therapy is due to the lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4fe9ae08d5af612f9a7275a3df65ce1
https://doi.org/10.1101/2021.08.20.457065
https://doi.org/10.1101/2021.08.20.457065
Autor:
András Málnási-Csizmadia, Tamás Hegedus, Agnes K. Mike, Mátyás C. Földi, K. Pesti, Katalin Zboray, Peter Lukacs
Sodium channel inhibitor drugs can exert their effect by either blocking, or modulating the channel. The extent of modulation versus channel block is crucial regarding the therapeutic potential of drug candidates. Modulation can be selective for path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facbf78674e1182470cf5da78b924dbc
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 2, p e1000008 (2008)
The absence of a functional ATP Binding Cassette (ABC) protein called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) from apical membranes of epithelial cells is responsible for cystic fibrosis (CF). Over 90% of CF patients carry at l
Externí odkaz:
https://doaj.org/article/47dbca58aef04f2e950b2187c798b625
Autor:
Anna Brózik, Kinga András, Hedvig Tordai, Tamás Hegedus, Balázs Sarkadi, Gergely Gyimesi, Kristóf Jakab
Publikováno v:
Database: The Journal of Biological Databases and Curation
ABC (ATP-Binding Cassette) proteins with altered function are responsible for numerous human diseases. To aid the selection of positions and amino acids for ABC structure/function studies we have generated a database, ABCMdb (Gyimesi et al., ABCMdb:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec1a7e1cf0a8dfdcb94b1972eb72db4
https://doi.org/10.1093/database/bax023
https://doi.org/10.1093/database/bax023
Autor:
Miklós Bagdány, Mark J. Kurth, Johanna F. Dekkers, Haijin Xu, Guido Veit, Tsukasa Okiyoneda, Gergely L. Lukacs, Ariel Roldan, Alan S. Verkman, Ágnes Simon, Jeffrey M. Beekman, Naoto Soya, Tamás Hegedus
Publikováno v:
Nature Chemical Biology. 9:444-454
The most common cystic fibrosis mutation, ΔF508 in nucleotide binding domain 1 (NBD1), impairs cystic fibrosis transmembrane conductance regulator (CFTR)-coupled domain folding, plasma membrane expression, function and stability. VX-809, a promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ee3f1d68279e05f59c2456e30eb068
https://doi.org/10.1038/nchembio.1253
https://doi.org/10.1038/nchembio.1253
Autor:
Tamás Hegedus, Gergely Szakács, Anna Brózik, Csilla Özvegy-Laczka, Csilla Hegedüs, Balázs Sarkadi, Zsuzsa Erdei
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 7:623-642
Anticancer tyrosine kinase inhibitors (TKIs) are small molecule hydrophobic compounds designed to arrest aberrant signaling pathways in malignant cells. Multidrug resistance (MDR) ATP binding cassette (ABC) transporters have recently been recognized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0efefbaa21a9a3965b24ea70eaeb63d
https://doi.org/10.1517/17425255.2011.562892
https://doi.org/10.1517/17425255.2011.562892
Autor:
Timothy J. Jensen, Tamás Hegedus, Liying Cui, John R. Riordan, Andrei A. Aleksandrov, April Mengos
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788:1341-1349
The cystic fibrosis transmembrane conductance regulator (CFTR) plays a critical role in transcellular ion transport and when defective, results in the genetic disease cystic fibrosis. CFTR is novel in the ATP-binding cassette superfamily as an ion ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071595b557686decdfb384858894830f
https://doi.org/10.1016/j.bbamem.2009.03.015
https://doi.org/10.1016/j.bbamem.2009.03.015
Autor:
Xiu Bao Chang, Luba A. Aleksandrov, William E. Balch, Tamás Hegedus, Yue Xian Hou, Lihua He, Martina Gentzsch, John R. Riordan, Andrei A. Aleksandrov, Liying Cui
Publikováno v:
Journal of Molecular Biology. 365:981-994
The dimerization of their two nucleotide binding domains (NBDs) in a so-called "nucleotide-sandwich" is the hallmark of ATP cassette binding (ABC) proteins and the basis of their catalytic activities. The major disease-causing mutation in the cystic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8143ac435e8e021c3f4b73f3ddd358
https://doi.org/10.1016/j.jmb.2006.10.086
https://doi.org/10.1016/j.jmb.2006.10.086