Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Tamás Hegedűs"'
Autor:
Blanka Berta, Hedvig Tordai, Gergely L. Lukács, Béla Papp, Ágnes Enyedi, Rita Padányi, Tamás Hegedűs
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The clinical management of severe COVID-19 cases is not yet well resolved. Therefore, it is important to identify and characterize cell signaling pathways involved in virus pathogenesis that can be targeted therapeutically. Envelope (E) prot
Externí odkaz:
https://doaj.org/article/b1a35e72b7564ce294fa597e41590c61
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Single amino acid substitutions can profoundly affect protein folding, dynamics, and function. The ability to discern between benign and pathogenic substitutions is pivotal for therapeutic interventions and research directions. Given the lim
Externí odkaz:
https://doaj.org/article/ebdfafeb85e240558d1f013b266f21f4
Autor:
Orsolya Mózner, Boglárka Zámbó, Zsuzsa Bartos, Anna Gergely, Kata Sára Szabó, Bálint Jezsó, Ágnes Telbisz, György Várady, László Homolya, Tamás Hegedűs, Balázs Sarkadi
Publikováno v:
Membranes, Vol 13, Iss 10, p 822 (2023)
The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, r
Externí odkaz:
https://doaj.org/article/d2e751a0cf98473c95d382c7980d6546
Autor:
Rita Padányi, Bianka Farkas, Hedvig Tordai, Bálint Kiss, Helmut Grubmüller, Naoto Soya, Gergely L. Lukács, Miklós Kellermayer, Tamás Hegedűs
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2587-2599 (2022)
Cystic fibrosis (CF) is a frequent genetic disease in Caucasians that is caused by the deletion of F508 (ΔF508) in the nucleotide binding domain 1 (NBD1) of the CF transmembrane conductance regulator (CFTR). The ΔF508 compromises the folding energe
Externí odkaz:
https://doaj.org/article/f824232d22a54693a0c1dca0363f6c83
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11341 (2023)
The human ABCB1 (P-glycoprotein, Pgp) protein is an active exporter expressed in the plasma membrane of cells forming biological barriers. In accordance with its broad substrate spectrum and tissue expression pattern, it affects the pharmacokinetics
Externí odkaz:
https://doaj.org/article/8a9bf80f301a4345bf114e6feb3e0ed8
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13744 (2022)
ABCG1 has been proposed to play a role in HDL-dependent cellular sterol regulation; however, details of the interaction between the transporter and its potential sterol substrates have not been revealed. In the present work, we explored the effect of
Externí odkaz:
https://doaj.org/article/35b7151c5ae94400a3d8d23f97bad2fb
Autor:
Boglárka Zámbó, Zsuzsa Bartos, Orsolya Mózner, Edit Szabó, György Várady, Gyula Poór, Márton Pálinkás, Hajnalka Andrikovics, Tamás Hegedűs, László Homolya, Balázs Sarkadi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The ABCG2 membrane protein is a key xeno- and endobiotic transporter, modulating the absorption and metabolism of pharmacological agents and causing multidrug resistance in cancer. ABCG2 is also involved in uric acid elimination and its impa
Externí odkaz:
https://doaj.org/article/985b89481f7e46d08466e8eaf2a472db
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 396-403 (2018)
Summary: An increasing number of ABC membrane protein structures are determined by cryo-electron microscopy and X-ray crystallography, consequently identifying differences between their conformations has become an arising issue. Therefore, we propose
Externí odkaz:
https://doaj.org/article/5cbdacf9c4c948c6957f1fd4a75b137d
Publikováno v:
Energies, Vol 14, Iss 8, p 2039 (2021)
The paper proposes a novel framework for state observer design, in which learning-based observers are incorporated. The aim of the method is to provide a framework, which is able to guarantee the limitation of the observation error, even if the error
Externí odkaz:
https://doaj.org/article/3afca96a52ae434cbe0ae825efa902c3
Publikováno v:
Applied Sciences, Vol 10, Iss 21, p 7716 (2020)
In the development of autonomous vehicles, the design of real-time motion-planning is a crucial problem. The computation of the vehicle trajectory requires the consideration of safety, dynamic and comfort aspects. Moreover, the prediction of the vehi
Externí odkaz:
https://doaj.org/article/b68a019de6974cdaa08259e5d86042be