Výsledky vyhledávání - "Tamás Gaszner"

Akademický článek

Neurodegeneration in the centrally-projecting Edinger–Westphal nucleus contributes to the non-motor symptoms of Parkinson’s disease in the rat

Autor: Balázs Ujvári, Bence Pytel, Zsombor Márton, Máté Bognár, László Ákos Kovács, József Farkas, Tamás Gaszner, Gergely Berta, Angéla Kecskés, Viktória Kormos, Boglárka Farkas, Nóra Füredi, Balázs Gaszner

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)

Abstract Background The neuropathological background of major depression and anxiety as non-motor symptoms of Parkinson’s disease is much less understood than classical motor symptoms. Although, neurodegeneration of the Edinger–Westphal nucleus i

Externí odkaz: https://doaj.org/article/749adc7e269846f8b223552ae1b54b24

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Akademický článek

Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy

Autor: Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Gergely Berta, Valér Csernus, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

According to the three hit concept of depression, interaction of genetic predisposition altered epigenetic programming and environmental stress factors contribute to the disease. Earlier we demonstrated the construct and face validity of our three hi

Externí odkaz: https://doaj.org/article/8a5afe64eaf8426e8f0dd45940d15cf6

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Peptidergic neurons of the Edinger–Westphal nucleus express TRPA1 ion channel that is downregulated both upon chronic variable mild stress in male mice and in humans who died by suicide

Autor: Viktória Kormos, Angéla Kecskés, József Farkas, Tamás Gaszner, Valér Csernus, Ammar Alomari, Dániel Hegedüs, Éva Renner, Miklós Palkovits, Dóra Zelena, Zsuzsanna Helyes, Erika Pintér, Balázs Gaszner

Publikováno v: Journal of Psychiatry and Neuroscience. 47:E162-E175

Transient receptor potential ankyrin 1 (TRPA1), a cation channel, is expressed predominantly in primary sensory neurons, but its central distribution and role in mood control are not well understood. We investigated whether TRPA1 is expressed in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3387fab8932612c3be4eaa7ca890ab30
https://doi.org/10.1503/jpn.210187

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Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice

Autor: Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11739

Depression and its increasing prevalence challenge patients, the healthcare system, and the economy. We recently created a mouse model based on the three-hit concept of depression. As genetic predisposition (first hit), we applied pituitary adenylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360d2d2f95fdc12b230c8aa6a4de22ce
https://pubmed.ncbi.nlm.nih.gov/36233039

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Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background

Autor: Viktória Kormos, Anna Elisabeth Nafz, László Gáspár, Hitoshi Hashimoto, Jozsef Farkas, Balázs Gaszner, László Á. Kovács, Valér Csernus, Balázs Ujvári, Dóra Reglődi, Tamás Gaszner

Publikováno v: Neuroscience. 354:11-29

Major depression is a common cause of chronic disability. Despite decades of efforts, no equivocally accepted animal model is available for studying depression. We tested the validity of a new model based on the three-hit concept of vulnerability and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2ea59f59b9f3312ef6059689892830
https://doi.org/10.1016/j.neuroscience.2017.04.019

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Using PACAP Heterozygous Mice as Models of the Three Hit Theory of Depression

Autor: Tamás Gaszner, László Á. Kovács, Jozsef Farkas, Balázs Gaszner

Publikováno v: Current Topics in Neurotoxicity ISBN: 9783319351339

Depression and mood disorders belong to the most common reasons for disability. Despite several decades of stress research many questions remained to be answered. One reason for slow progress in this field may be explained by the lack of equivocally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9616bf73829723ff1edcd35bb7b03102
https://doi.org/10.1007/978-3-319-35135-3_42

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Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers

Autor: László Á. Kovács, Valér Csernus, Hitoshi Hashimoto, Dóra Reglődi, Jozsef Farkas, Zsuzsanna Helyes, László Gáspár, Tamás Gaszner, András Balogh, Viktória Kormos, Balázs Gaszner

Publikováno v: Neuroscience. 330

Pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in stress adaptation with potential relevance in mood disorder management. PACAP deficient (KO) mice on CD1 background were shown to have depression-like phenotype. Here w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba68a44a60d900b4564b65a78d27d0b
https://pubmed.ncbi.nlm.nih.gov/27282087

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