Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Talyn, Chu"'
Autor:
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mócsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Siglec-H is a DAP12-associated receptor on plasmacytoid dendritic cells (pDCs) and microglia. Siglec-H inhibits TLR9-induced IFN-α production by pDCs. Previously, it was found that Siglec-H-deficient mice develop a lupus-like severe autoimmune disea
Externí odkaz:
https://doaj.org/article/c505db08fdab443ead7dba66ecb91da3
Autor:
Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christoph A. Mayer, Percy Knolle, Martin Klingenspor, Valeria Fumagalli, Matteo Iannacone, Martin Prlic, Thomas Korn, Erika L. Pearce, Thomas Höfer, Anna M. Schulz, Dietmar Zehn
Publikováno v:
Nature Immunology
Blocking pyrimidine de novo synthesis by inhibiting dihydroorotate dehydrogenase is used to treat autoimmunity and prevent expansion of rapidly dividing cell populations including activated T cells. Here we show memory T cell precursors are resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085f2909a004801c889c7b71682d6c58
https://doi.org/10.1038/s41590-023-01436-x
https://doi.org/10.1038/s41590-023-01436-x
Autor:
Talyn Chu, Aaron J. Tyznik, Sarah Roepke, Amy M. Berkley, Amanda Woodward-Davis, Laura Pattacini, Michael J. Bevan, Dietmar Zehn, Martin Prlic
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 701-708 (2013)
During an infection the antigen-nonspecific memory CD8 T cell compartment is not simply an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells contribute to the clearance of an infection. We measured the strength o
Externí odkaz:
https://doaj.org/article/71f974dbfbf746a5b16a96e191a55bf6
Autor:
Dietmar Zehn, Talyn Chu
Publikováno v:
Immunity
CD8(+) T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite this, the developmental biology of exhausted CD8(+) T cells (Tex) remains poorly defined, restraining improvement of strategies aimed at “re-invigorating”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec53344e38247e555b44932261f76714
https://doi.org/10.1016/j.immuni.2020.04.019
https://doi.org/10.1016/j.immuni.2020.04.019
Publikováno v:
The Journal of Immunology. 202:2529-2534
Systemic lupus erythematosus severity correlates with elevated serum levels of type I IFNs, cytokines produced in large quantities by plasmacytoid dendritic cells (pDC) in response to engagement of TLR7 and TLR9 with endocytosed nucleic acids. B cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab3195d60bb5ed6d7f1c06e2146452ec
https://doi.org/10.4049/jimmunol.1801267
https://doi.org/10.4049/jimmunol.1801267
Publikováno v:
Nature immunology
T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c099eb42c952e22b196c015a15529e4e
https://pubmed.ncbi.nlm.nih.gov/33046887
https://pubmed.ncbi.nlm.nih.gov/33046887
Autor:
Amanda Woodward-Davis, Amy M. Berkley, Dietmar Zehn, Laura Pattacini, Talyn Chu, Martin Prlic, Michael J. Bevan, Sarah Roepke, Aaron J. Tyznik
Publikováno v:
Cell reports
Cell Reports, vol. 3, no. 3, pp. 701-708
Cell Reports, Vol 3, Iss 3, Pp 701-708 (2013)
Cell Reports, vol. 3, no. 3, pp. 701-708
Cell Reports, Vol 3, Iss 3, Pp 701-708 (2013)
During an infection the antigen non-specific memory CD8 T cell compartment is not simply an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells contribute to the clearance of an infection. We measured the strength
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ea448692a2e6d23066c4afcf623057
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628815/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628815/
Autor:
Michal Kremen, Isaac Emery, Stephen A. Ramsey, David A. Dichek, Stephen D. Farris, Elizabeth S. Gold, Ranjini M. Krishnan, Helén L. Dichek, Talyn Chu, Jie Hong Hu, Liang Du
Publikováno v:
Journal of Biological Chemistry. 286:22665-22677
Data from clinical studies, cell culture, and animal models implicate the urokinase plasminogen activator (uPA)/uPA receptor (uPAR)/plasminogen system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/uPAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008efea7d815eec15f8f1c73b90e8009
https://doi.org/10.1074/jbc.m110.202135
https://doi.org/10.1074/jbc.m110.202135
Publikováno v:
The Journal of Immunology. 200:41.11-41.11
Systemic lupus erythematosus (SLE) severity is correlated with elevated serum type I interferons (IFN), mainly IFNα, which is produced in large amounts by pDC in response to nucleic acid sensing by TLR7 and TLR9. TLR7 and TLR9-induced IRF7 transloca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e25d2c94ee51124ce19ef2f56fd109e
https://doi.org/10.4049/jimmunol.200.supp.41.11
https://doi.org/10.4049/jimmunol.200.supp.41.11
Autor:
Jie Hong Hu, Helén L. Dichek, Liang Du, Stephen D. Farris, Katherine I. Slezicki, Talyn Chu, Isaac Emery, David A. Dichek, Michal Kremen, Ranjini M. Krishnan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 29:1737-1744
Objective— Enhanced plasminogen activation, mediated by overexpression of urokinase-type plasminogen activator (uPA), accelerates atherosclerosis in apolipoprotein E–null mice. However, the mechanisms through which uPA acts remain unclear. In add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61267225389de06e7ee6d4c1d513954d
https://doi.org/10.1161/atvbaha.109.195529
https://doi.org/10.1161/atvbaha.109.195529