Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Talvinder S. Sihra"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
We elucidated the mechanisms underlying the kainate receptor (KAR)-mediated facilitatory modulation of synaptic transmission in the cerebellum. In cerebellar slices, KA (3 μM) increased the amplitude of evoked excitatory postsynaptic currents (eEPSC
Externí odkaz:
https://doaj.org/article/3ffb3e5920f34fa48a4e0c577bde0b1a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patient
Externí odkaz:
https://doaj.org/article/21a67b3245524e01a4c3cd9dde241c44
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
A metabotropic modus operandi for kainate receptors (KARs) was first discovered in 1998 modulating GABA release. These receptors have been also found to modulate glutamate release at different synapses in several brain regions. Mechanistically, a gen
Externí odkaz:
https://doaj.org/article/6681bcb6c94944479c85e5be218ebd3e
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ce542dcc96789c520481d0333c7df8
http://europepmc.org/articles/PMC6023982
http://europepmc.org/articles/PMC6023982
Publikováno v:
Journal of Neurochemistry. 126:565-578
We have investigated the mechanisms underlying the facilitatory modulation mediated by kainate receptor (KAR) activation in the cortex, using isolated nerve terminals (synaptosomes) and slice preparations. In cortical nerve terminals, kainate (KA, 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6087c624d864f3c333a2ca64d326e0
https://doi.org/10.1111/jnc.12310
https://doi.org/10.1111/jnc.12310
Publikováno v:
The Neuroscientist. 20:29-43
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f596fbecc9eb89e2a396dcc01e9ed0fc
https://doi.org/10.1177/1073858413478196
https://doi.org/10.1177/1073858413478196
Autor:
Talvinder S. Sihra, José Vicente Negrete-Díaz, Gonzalo Flores, Paloma Duque-Feria, Antonio Rodríguez-Moreno, Yuniesky Andrade-Talavera
Publikováno v:
Journal of Neurochemistry. 122:891-899
Presynaptic kainate receptors (KARs) modulate the release of glutamate at synapses established between mossy fibers (MF) and CA3 pyramidal cells in the hippocampus. The activation of KAR by low, nanomolar, kainate concentrations facilitates glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3042aaeff50088fc5cea94f0b866df02
https://doi.org/10.1111/j.1471-4159.2012.07844.x
https://doi.org/10.1111/j.1471-4159.2012.07844.x
Autor:
Christophe Porcher, Jasmina N. Jovanovic, Stephen J. Moss, Kristina McAinch, Alex M. Thomson, Rebecca Longbottom, Caroline S. Hatchett, Talvinder S. Sihra
Publikováno v:
Journal of Biological Chemistry. 286:21667-21677
During the early development of the nervous system, γ-aminobutyric acid (GABA) type A receptor (GABA(A)R)-mediated signaling parallels the neurotrophin/tropomyosin-related kinase (Trk)-dependent signaling in controlling a number of processes from ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6719f946cf6c31f412eda423940d30
https://doi.org/10.1074/jbc.m110.201582
https://doi.org/10.1074/jbc.m110.201582
Autor:
Philip Long, Jasmina N. Jovanovic, Jennifer Davies, Vivian W. Y. Lee, Sohaib Nizami, Talvinder S. Sihra
Publikováno v:
Biochemical Society Transactions. 38:529-535
The signalling roles of Ca(2+)(ic) (intracellular Ca(2+)) stores are well established in non-neuronal and neuronal cells. In neurons, although Ca(2+)(ic) stores have been assigned a pivotal role in postsynaptic responses to G(q)-coupled receptors, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f070d42355402d58f85727a61a9fbdc8
https://doi.org/10.1042/bst0380529
https://doi.org/10.1042/bst0380529
Autor:
Shane Minogue, Claudia G. Wiedemann, Raya Al-Shawi, Stylianos Evangelou, J. Justin Hsuan, J. Paul Simons, Thomas T. Warner, Rosalind H.M. King, Talvinder S. Sihra, Mark G. Waugh, Andrzej Loesch
Publikováno v:
Proceedings of the National Academy of Sciences. 106:11535-11539
Phosphoinositide (PI) lipids are intracellular membrane signaling intermediates and effectors produced by localized PI kinase and phosphatase activities. Although many signaling roles of PI kinases have been identified in cultured cell lines, transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957fc6a356a23330c2fae27aa31f2bf9
https://doi.org/10.1073/pnas.0903011106
https://doi.org/10.1073/pnas.0903011106