Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase.

Autor: Talibov VO; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 754 24, Uppsala, Sweden., Fabini E; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.; Institute for Organic Synthesis and Photoreactivity, National Research Council, Via P. Gobetti 101, 40129, Bologna, Italy., FitzGerald EA; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 754 24, Uppsala, Sweden.; Beactica Therapeutics AB, Virdings allé 2, 754 50, Uppsala, Sweden., Tedesco D; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.; Institute for Organic Synthesis and Photoreactivity, National Research Council, Via P. Gobetti 101, 40129, Bologna, Italy., Cederfeldt D; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 754 24, Uppsala, Sweden., Talu MJ; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 754 24, Uppsala, Sweden., Rachman MM; Institut de Biomedicina de la Universitat de Barcelona (IBUB) and Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028, Barcelona, Spain., Mihalic F; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 754 24, Uppsala, Sweden., Manoni E; Institute for Organic Synthesis and Photoreactivity, National Research Council, Via P. Gobetti 101, 40129, Bologna, Italy., Naldi M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.; Centre for Applied Biomedical Research, Alma Mater Studiorum University of Bologna, Via Zamboni, 33, Bologna, 40126, Italy., Sanese P; Medical Genetics, National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, 70013, Bari, Italy., Forte G; Medical Genetics, National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, 70013, Bari, Italy., Lepore Signorile M; Medical Genetics, National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, 70013, Bari, Italy., Barril X; Institut de Biomedicina de la Universitat de Barcelona (IBUB) and Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028, Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluis Companys 23, 08010, Barcelona, Spain., Simone C; Medical Genetics, National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, 70013, Bari, Italy.; Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari Aldo Moro, 70124, Bari, Italy., Bartolini M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy., Dobritzsch D; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 754 24, Uppsala, Sweden., Del Rio A; Institute for Organic Synthesis and Photoreactivity, National Research Council, Via P. Gobetti 101, 40129, Bologna, Italy.; Innovamol Consulting Srl, Via Giardini 470/H, 41124, Modena, Italy., Danielson UH; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 754 24, Uppsala, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala, 752 37, Sweden.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 May 04; Vol. 22 (9), pp. 1597-1608. Date of Electronic Publication: 2021 Feb 11.