ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

Autor: Pownall Henry J, Nathan David M, Balasubramanyam Ashok, McCaffrey Jeanne M, Kopin Alan, Cooper Jackie A, Montefusco Maria, Kelley-Hedgepeth Alyson, Smart-Halajko Melissa C, Peter Inga, Talmud Philippa J, Huggins Gordon S

Publikováno v: BMC Medical Genetics, Vol 12, Iss 1, p 89 (2011)

Abstract Background Elevated triglyceride levels are a risk factor for cardiovascular disease. Angiopoietin-like protein 4 (Angptl4) is a metabolic factor that raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). In non-diabetic

Externí odkaz: https://doaj.org/article/0ee930877ae64ed08ecfafde609a42b8

Adult height, coronary heart disease and stroke : A multi-locus Mendelian randomization meta-analysis

Autor: Nüesch, Eveline, Dale, Caroline, Palmer, Tom M., White, Jon, Keating, Brendan J., van Iperen, Erik P A, Goel, Anuj, Padmanabhan, Sandosh, Asselbergs, F. W., Verschuren, W. M., Wijmenga, C., Van der Schouw, Y. T., Onland-Moret, N. C., Lange, Leslie A., Hovingh, G. K., Sivapalaratnam, Suthesh, Morris, Richard W., Whincup, Peter H., Wannamethe, Goya S., Gaunt, Tom R., Ebrahim, Shah, Steel, Laura, Nair, Nikhil, Reiner, Alexander P., Kooperberg, Charles, Wilson, James F., Bolton, Jennifer L., McLachlan, Stela, Price, Jacqueline F., Strachan, Mark W J, Robertson, Christine M., Kleber, Marcus E., Delgado, Graciela, März, Winfried, Melander, Olle, Dominiczak, Anna F., Farrall, Martin, Watkins, Hugh, Leusink, Maarten, Maitland-van der Zee, Anke H., de Groot, Mark C H, Dudbridge, Frank, Hingorani, Aroon, Ben-Shlomo, Yoav, Lawlor, Debbie A., Amuzu, A., Caufield, M., Cavadino, A., Cooper, J., Davies, T. L., Day, I. N., Drenos, F., Engmann, J., Finan, C., Giambartolomei, C., Hardy, R., Humphries, S. E., Hypponen, E., Kivimaki, M., Kuh, D., Kumari, M., Ong, K., Plagnol, V., Power, C., Richards, M., Shah, S., Shah, T., Sofat, R., Talmud, P. J., Wareham, N., Warren, H., Whittaker, J. C., Wong, A., Zabaneh, D., Smith, George Davey, Wells, Jonathan C., Leon, David A., Holmes, Michael V., Casas, Juan P.

Publikováno v: International Journal of Epidemiology, 45(6), 1927. Oxford University Press

© The Author 2015; all rights reserved. Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2f0112c7e185d039dfc19dd0c6244ba0
https://dspace.library.uu.nl/handle/1874/332756

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D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

Autor: Valleix, S., Guglielmo Verona, Jourde-Chiche, N., Nédelec, B., Mangione, P. P., Bridoux, F., Mangé, A., Dogan, A., Goujon, J. -M, Lhomme, M., Dauteuille, C., Chabert, M., Porcari, R., Waudby, C. A., Relini, A., Talmud, P. J., Kovrov, O., Olivecrona, G., Stoppini, M., Christodoulou, J., Hawkins, P. N., Grateau, G., Delpech, M., Kontush, A., Gillmore, J. D., Kalopissis, A. D., Bellotti, V.

Publikováno v: Nature Communications
Nature Communications, 2016, pp.10353. ⟨10.1038/ncomms10353⟩
Scopus-Elsevier
Nature Communications, Nature Publishing Group, 2016, pp.10353
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications, Nature Publishing Group, 2016, pp.10353. ⟨10.1038/ncomms10353⟩

Apolipoprotein C-III deficiency provides cardiovascular protection, but apolipoprotein C-III is not known to be associated with human amyloidosis. Here we report a form of amyloidosis characterized by renal insufficiency caused by a new apolipoprotei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::194cade83039b6591442874b6285d900
https://amu.hal.science/hal-01467259/document

Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures

Autor: Smart, M C, Dedoussis, G, Yiannakouris, N, Grisoni, M L, Dror, G K, Yannakoulia, M, Papoutsakis, C, Louizou, E, Mantzoros, C S, Melistas, L, Kontogianni, M D, Cooper, J A, Humphries, S E, Talmud, P J, Vidra, Nikoletta

Publikováno v: Nutrition, Metabolism, and Cardiovascular Diseases
NMCD : Nutrition, Metabolism and Cardiovascular Diseases, 21(7), 476-484. ELSEVIER SCI LTD

BACKGROUND AND AIMS: IL-18 expression is up-regulated in atherosclerotic plaques, and higher levels are seen in obese and Type 2 Diabetic individuals. More recently, a possible role for IL-18 in glucose and energy homeostasis has been suggested.METHO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a3c7b0a004fea8f47bbe86aab7520c
https://doi.org/10.1016/j.numecd.2009.12.004