Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Autor: Simon Schröder, Anja Richter, Talitha Veith, Jackson Emanuel, Luca Gudermann, Kirstin Friedmann, Lara M. Jeworowski, Barbara Mühlemann, Terry C. Jones, Marcel A. Müller, Victor M. Corman, Christian Drosten

Publikováno v: Virology Journal, Vol 20, Iss 1, Pp 1-13 (2023)

Abstract Background Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly map

Externí odkaz: https://doaj.org/article/faa93fcd2deb4a35b9efcfc3602c8045

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

Autor: Simon Schroeder, MSc, Fabian Pott, MSc, Daniela Niemeyer, PhD, Talitha Veith, MPhil, Anja Richter, Doreen Muth, PhD, Christine Goffinet, ProfPhD, Marcel A Müller, PhD, Christian Drosten, ProfPhD

Publikováno v: The Lancet Microbe, Vol 2, Iss 5, Pp e210-e218 (2021)

Summary: Background: The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the viruses share a completely homologous repertoire of proteins and use the

Externí odkaz: https://doaj.org/article/819ce5aee3df4748b4a4a8a997aedc0c

Non-structural genes of novel lemur adenoviruses reveal codivergence of virus and host

Autor: Talitha Veith, Tobias Bleicker, Monika Eschbach-Bludau, Sebastian Brünink, Barbara Mühlemann, Julia Schneider, Jörn Beheim-Schwarzbach, S Jacques Rakotondranary, Yedidya R Ratovonamana, Cedric Tsagnangara, Refaly Ernest, Faly Randriantafika, Simone Sommer, Nadine Stetter, Terry C Jones, Christian Drosten, Jörg U Ganzhorn, Victor M Corman

Publikováno v: Virus Evolution. 9

Adenoviruses (AdVs) are important human and animal pathogens and are frequently used as vectors for gene therapy and vaccine delivery. Surprisingly, there are only scant data regarding primate AdV origin and evolution, especially in the most basal pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8229ffa6eb58800ed72240bd5fae29
https://doi.org/10.1093/ve/vead024

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

Autor: Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Julian Heinze, Anja Richter, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M. Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Felix Walper, Marie L. Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Terry C. Jones, Markus Morkel, Sandra Ciesek, Leif G. Hanitsch, Marcus A. Mall, Andreas C. Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M. Corman, Marcel A. Müller, Christine Goffinet, Christian Drosten

Publikováno v: Niemeyer, Daniela; Stenzel, Saskia; Veith, Talitha; Schroeder, Simon; Friedmann, Kirstin; Weege, Friderike; Trimpert, Jakob; Heinze, Julian; Richter, Anja; Jansen, Jenny; Emanuel, Jackson; Kazmierski, Julia; Pott, Fabian; Jeworowski, Lara M.; Olmer, Ruth; Jaboreck, Mark-Christian; Tenner, Beate; Papies, Jan; Walper, Felix; Schmidt, Marie L.; ... (2022). SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. PLoS biology, 20(11), e3001871. Public Library of Science 10.1371/journal.pbio.3001871

Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c3293ea12289a5a44136329bcbe57e
https://pubmed.ncbi.nlm.nih.gov/36383605

Rabies virus in slaughtered dogs for meat consumption in Ghana: A potential risk for rabies transmission

Autor: Philip El-Duah, Benjamin Obukowho Emikpe, Ernest Akyereko, Julia Schneider, Vitus Burimuah, Eddie-Williams Owiredu, Tobias Bleicker, RD Folitse, S. Johnson, William Tasiame, Talitha Veith, Christian Drosten, Victor M. Corman

Publikováno v: Transboundary and Emerging Diseases. 69

Dog-mediated rabies is responsible for approximately 60,000 human deaths annually worldwide. Although dog slaughter for human consumption and its potential risk for rabies transmission has been reported, mainly in some parts of Western Africa and Sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c16122e0f3ad3356567cb7009536fd1
https://doi.org/10.1111/tbed.14266