42. INSPIRE-ASP UTI Trial: A 59 Hospital Cluster Randomized Evaluation of INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection versus Routine Antibiotic Selection Practices for Patients with Urinary Tract Infection (UTI)

Autor: Shruti K Gohil, Edward Septimus, Ken Kleinman, Neha Varma, Lauren Heim, Syma Rashid, Risa Rahm, William S Cooper, Laura E McLean, Naoise G Nickolay, Robert A Weinstein, Edward Rosen, Taliser R Avery, Sljivo Selsebil, Justin Vigeant, Kenneth Sands, Mandelin Cooper, H L Burgess, Julia Moody, Micaela H Coady, Gilbert F Rebecca, Kimberly N Smith, Brandon Carver, Caren Spencer-Smith, Russell Poland, Jason Hickok, S G Sturdevant, Anastasiia Weiland, Abinav Gowda, Robert Wolf, Mary K Hayden, Sujan Reddy, Melinda M Neuhauser, Arjun Srinivasan, David W Kubiak, John A Jernigan, Jonathan B Perlin, Richard Platt, Susan S Huang

Publikováno v: Open Forum Infectious Diseases

Background Up to 40% of hospitalized patients receive unnecessary or inappropriately broad antibiotics despite a low risk of multidrug-resistant organism (MDRO) infection. Empiric standard spectrum antibiotic use would reduce extended-spectrum (ES) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acfb31f2ff694c08def5974489a5ccc
http://europepmc.org/articles/PMC8643895

4. 137 Hospital Cluster-Randomized Trial of Mupirocin-Chlorhexidine vs Iodophor-Chlorhexidine for Universal Decolonization in Intensive Care Units (ICUs) (Mupirocin Iodophor Swap Out Trial)

Autor: Susan S Huang, Edward Septimus, Ken Kleinman, Lauren Heim, Julia Moody, Taliser R Avery, Laura E McLean, Syma Rashid, Katherine Haffenreffer, Lauren Shimelman, Whitney Staub-Juergens, Caren Spencer-Smith, Selsebil Sljivo, Ed Rosen, Russell Poland, Micaela H Coady, Eunice J Blanchard, Kimberly Reddish, Mary K Hayden, Robert A Weinstein, Brandon Carver, Kimberly N Smith, Jason Hickok, Karen Lolans, Nadia Khan, S G Sturdevant, Sujan Reddy, John A Jernigan, Kenneth Sands, Jonathan B Perlin, Richard Platt

Publikováno v: Open Forum Infectious Diseases

Background ICU universal decolonization with daily chlorhexidine (CHG) baths plus mupirocin nasal decolonization reduces all-cause bloodstream infections (BSI) and MRSA clinical cultures. We assessed nasal iodophor, an antiseptic less susceptible to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a069fef4d4c09d69b73132b7fdbbb997
http://europepmc.org/articles/PMC8644071

Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial

Autor: Tyler Forehand, Edward Septimus, Ken Kleinman, Mary K. Hayden, Lauren Shimelman, John A. Jernigan, Jonathan B. Perlin, Julia Moody, Abate Infection trial team, Richard Platt, Robert A. Weinstein, Lena M. Portillo, Jason Hickok, Lauren Heim, Katherine Haffenreffer, Caren Spencer-Smith, Susan S. Huang, Julie Lankiewicz, Michael V. Murphy, Taliser R. Avery, Micaela H Coady, Jalpa Sarup-Patel, Adrijana Gombosev, Rebecca E. Kaganov

Publikováno v: Lancet (London, England), vol 393, iss 10177

BACKGROUND:Universal skin and nasal decolonisation reduces multidrug-resistant pathogens and bloodstream infections in intensive care units. The effect of universal decolonisation on pathogens and infections in non-critical-care units is unknown. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f799bc9f80b52cb5462d4497b8faaf
https://escholarship.org/uc/item/7vt4b9jj

Chlorhexidine Versus Routine Bathing to Prevent Multi Drug-Resistant Organisms and All-Cause Bloodstream Infection in General Medical and Surgical Units: The ABATE Infection Cluster Randomized Trial

Autor: Micaela H Coady, Katherine Haffenreffer, Mary K. Hayden, Julie Lankiewicz, Adrijana Gombosev, Edward Septimus, Jalpa Sarup-Patel, Michael V. Murphy, Ken Kleinman, Julia Moody, Rebecca E. Kaganov, Jason Hickok, John A. Jernigan, Lauren Heim, Tyler Forehand, Jonathan B. Perlin, Richard Platt, Lena M. Portillo, Susan S. Huang, Taliser R. Avery, Robert A. Weinstein, Lauren Shimelman, Caren Spencer-Smith

Publikováno v: SSRN Electronic Journal.

Background: Universal skin and nasal decolonization reduces multidrug-resistant pathogens and bloodstream infections in intensive care units. The effect of universal decolonization on pathogens and infections in non-critical care units is unknown. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd56f0d80d3e3b3f400507f57fdbe79e
https://doi.org/10.2139/ssrn.3214865

Cost Savings of Universal Decolonization to Prevent Intensive Care Unit Infection: Implications of the REDUCE MRSA Trial

Autor: Grace M. Lee, Julia Moody, Robert A. Weinstein, Richard Platt, G. Thomas Ray, Edward Septimus, Mary K. Hayden, Jonathan B. Perlin, Susan S. Huang, Jason Hickok, Taliser R. Avery

Publikováno v: Huang, SS; Septimus, E; Avery, TR; Lee, GM; Hickok, J; Weinstein, RA; et al.(2014). Cost savings of universal decolonization to prevent intensive care unit infection: Implications of the REDUCE MRSA trial. Infection Control and Hospital Epidemiology, 35, S23-S31. doi: 10.1086/677819. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/43g0531q
Infection control and hospital epidemiology, vol 35 Suppl 3, iss S3

Objective.To estimate and compare the impact on healthcare costs of 3 alternative strategies for reducing bloodstream infections in the intensive care unit (ICU): methicillin-resistant Staphylococcus aureus (MRSA) nares screening and isolation, targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bc34e83207a8dc4b2cadd8919f4c0a
https://doi.org/10.1086/677819