Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Talin Haritunians"'
Autor:
George B. McDonald, Ole J.B. Landsverk, Dermot P.B. McGovern, Anders Aasebø, Vemund Paulsen, Talin Haritunians, Henrik M. Reims, Bernadette M. McLaughlin, Timothy Zisman, Dalin Li, Elisabeth T.M.M. Elholm, Frode L. Jahnsen, George E. Georges, Tobias Gedde-Dahl
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e24026- (2024)
Background & aims: Durable remissions of Crohn's Disease (CD) have followed myeloablative conditioning therapy and allogeneic marrow transplantation. For patients with treatment-refractory disease, we used reduced-intensity conditioning to minimize t
Externí odkaz:
https://doaj.org/article/bdeefb3eb92c4e6ab5819534e0b1348b
Autor:
Ellen Besa, Mizinga Jacqueline Tembo, Chola Mulenga, Monica Mweetwa, Naheed Choudhry, Kanta Chandwe, Chad Storer, Richard Head, Beatrice Amadi, Talin Haritunians, Dermot McGovern, Geoffrey Kwenda, Madusha Peiris, Paul Kelly
Publikováno v:
Experimental Physiology, Vol 108, Iss 4, Pp 568-580 (2023)
Abstract Nutrient sensing determines digestive and hormonal responses following nutrient ingestion. We have previously reported decreased levels of glucagon‐like peptide 2 (GLP‐2) in children with stunting. Here we demonstrate the presence of ent
Externí odkaz:
https://doaj.org/article/bc24b31a51984a9d917f4c24e44b42f5
Autor:
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Girish Nadkarni, Lee A. Denson, Harry Ostrer, Adam P. Levine, Elena R. Schiff, Anthony W. Segal, Subra Kugathasan, Peter D. Stenson, David N. Cooper, L. Philip Schumm, Scott Snapper, Mark J. Daly, Talin Haritunians, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Steven R. Brant, Dermot P. B. McGovern, Judy H. Cho, Yuval Itan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Inflammatory bowel disease (IBD) is a group of chronic digestive tract inflammatory conditions whose genetic etiology is still poorly understood. The incidence of IBD is particularly high among Ashkenazi Jews. Here, we identify 8 novel and p
Externí odkaz:
https://doaj.org/article/9b4ce2bc11f1400dba2682d34318447c
Autor:
Ruize Liu, Dalin Li, Talin Haritunians, Yunfeng Ruan, Mark J. Daly, Hailiang Huang, Dermot P.B. McGovern
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108053- (2023)
Summary: Crohn's disease (CD) and ulcerative colitis (UC) are two etiologically related yet distinctive subtypes of the inflammatory bowel diseases (IBD). Differentiating CD from UC can be challenging using conventional clinical approaches in a subse
Externí odkaz:
https://doaj.org/article/b58507f1cf4a4f8988b7b108bb9132d6
Autor:
Jonathan P. Jacobs, Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Maomeng Tong, Paul Ruegger, Talin Haritunians, Carol Landers, Philip Fleshner, Eric Vasiliauskas, Andrew Ippoliti, Gil Melmed, David Shih, Stephan Targan, James Borneman, Albert J. Fornace, Dermot P. B. McGovern, Jonathan Braun
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbi
Externí odkaz:
https://doaj.org/article/fe92c4592aad437cb5c862f197cb01d1
Autor:
Monica N. Mweetwa, Talin Haritunians, Shishir Dube, Kanta Chandwe, Beatrice Amadi, Kanekwa Zyambo, Ta-Chiang Liu, Dermot McGovern, Paul Kelly
Publikováno v:
PLoS ONE, Vol 18, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/c429995dcbbf4adbae892f9046c76deb
Autor:
Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103347- (2021)
Background: A non-synonymous single nucleotide polymorphism of the ATG16L1 gene, T300A, is a major Crohn's disease (CD) susceptibility allele, and is known to be associated with increased apoptosis induction in the small intestinal crypt base in CD s
Externí odkaz:
https://doaj.org/article/c5e63bed203f4d959a6a62c8a7adc23a
Autor:
Laxmi Sunuwar, Azra Frkatović, Sodbo Sharapov, Qinchuan Wang, Heather M. Neu, Xinqun Wu, Talin Haritunians, Fengyi Wan, Sarah Michel, Shaoguang Wu, Mark Donowitz, Dermot McGovern, Gordan Lauc, Cynthia Sears, Joanna Melia
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with an increased risk of schizophrenia, ob
Externí odkaz:
https://doaj.org/article/c8a8d7250ef44726afdebb8c100fb512
Autor:
Manuel A Rivas, Brandon E Avila, Jukka Koskela, Hailiang Huang, Christine Stevens, Matti Pirinen, Talin Haritunians, Benjamin M Neale, Mitja Kurki, Andrea Ganna, Daniel Graham, Benjamin Glaser, Inga Peter, Gil Atzmon, Nir Barzilai, Adam P Levine, Elena Schiff, Nikolas Pontikos, Ben Weisburd, Monkol Lek, Konrad J Karczewski, Jonathan Bloom, Eric V Minikel, Britt-Sabina Petersen, Laurent Beaugerie, Philippe Seksik, Jacques Cosnes, Stefan Schreiber, Bernd Bokemeyer, Johannes Bethge, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Graham Heap, Tariq Ahmad, Vincent Plagnol, Anthony W Segal, Stephan Targan, Dan Turner, Paivi Saavalainen, Martti Farkkila, Kimmo Kontula, Aarno Palotie, Steven R Brant, Richard H Duerr, Mark S Silverberg, John D Rioux, Rinse K Weersma, Andre Franke, Luke Jostins, Carl A Anderson, Jeffrey C Barrett, Daniel G MacArthur, Chaim Jalas, Harry Sokol, Ramnik J Xavier, Ann Pulver, Judy H Cho, Dermot P B McGovern, Mark J Daly
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008190 (2019)
[This corrects the article DOI: 10.1371/journal.pgen.1007329.].
Externí odkaz:
https://doaj.org/article/3ae352ebf0834370b7f64609330444d8
Autor:
Manuel A. Rivas, Daniel Graham, Patrick Sulem, Christine Stevens, A. Nicole Desch, Philippe Goyette, Daniel Gudbjartsson, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Frauke Degenhardt, Sören Mucha, Mitja I. Kurki, Dalin Li, Mauro D’Amato, Vito Annese, Severine Vermeire, Rinse K. Weersma, Jonas Halfvarson, Paulina Paavola-Sakki, Maarit Lappalainen, Monkol Lek, Beryl Cummings, Taru Tukiainen, Talin Haritunians, Leena Halme, Lotta L. E. Koskinen, Ashwin N. Ananthakrishnan, Yang Luo, Graham A. Heap, Marijn C. Visschedijk, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Daniel G. MacArthur, Benjamin M. Neale, Tariq Ahmad, Carl A. Anderson, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, Judy H Cho, Aarno Palotie, Päivi Saavalainen, Kimmo Kontula, Martti Färkkilä, Dermot P. B. McGovern, Andre Franke, Kari Stefansson, John D. Rioux, Ramnik J. Xavier, Mark J. Daly
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
While hundreds of loci are linked with inflammatory bowel diseases (IBDs), the functional consequences of the associated variants remain unclear. Here, the authors screened in ulcerative colitis (UC) patients’ genomes for protein-truncating variant
Externí odkaz:
https://doaj.org/article/7ec515461747449295bc0f9f7b59f420