Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Talia Zeppelin"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The human dopamine transporter (hDAT) is one in three members of the monoamine transporter family (MAT). hDAT is essential for regulating the dopamine concentration in the synaptic cleft through dopamine reuptake into the presynaptic neuron;
Externí odkaz:
https://doaj.org/article/8672ebf9631d40e4bbb79de58c8abfae
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005907 (2018)
Monoamine transporters (MATs) carry out neurotransmitter reuptake from the synaptic cleft, a key step in neurotransmission, which is targeted in the treatment of neurological disorders. Cholesterol (CHOL), a major component of the synaptic plasma mem
Externí odkaz:
https://doaj.org/article/3d3c0ed49bf24cddafe0f27de81be7ee
Publikováno v:
Ladefoged, L K, Zeppelin, T & Schiøtt, B 2019, ' Molecular modeling of neurological membrane proteins − from binding sites to synapses ', Neuroscience Letters, vol. 700, pp. 38-49 . https://doi.org/10.1016/j.neulet.2018.05.034
The field of molecular mechanics studies of proteins has developed enormously since its origin in the 1970’s, and many applications and methodologies have branched from the original idea of the force field. The applications of such methodologies ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bda57502c630bcfa46b053ed0dc85a
https://doi.org/10.1016/j.neulet.2018.05.034
https://doi.org/10.1016/j.neulet.2018.05.034
Autor:
Mikkel Christensen, Frauke Gräter, Talia Zeppelin, Ana-Nicoleta Bondar, Camilo Aponte-Santamaría, Kevin J. Boyd, Carmen Domene, Peter Pohl, Pedro A. Fernandes, Lucia Sessa, Birgit Schiøtt, Maria J. Ramos, Siewert J. Marrink, Durba Sengupta, Konstantina Karathanou, M. Joanne Lemieux, Peter J. Quinn, Ran Friedman, Csaba Daday, Mónica Pickholz, Stefano Piotto, Fabian Keller, Davit Hakobyan, Valeria Zoni, Syma Khalid, Floris J. van Eerden, Stefano Vanni, Eric R. May, Andreas Heuer, João Coimbra, Marlon Becker, Richard J. Naftalin, Antara Mazumdar, Elena Arutyunova, Simona Concilio
Publikováno v:
Friedman, R, Khalid, S, Aponte-Santamaría, C, Arutyunova, E, Becker, M, Boyd, K J, Christensen, M H, Coimbra, J T S, Concilio, S, Daday, C, van Eerden, F J, Fernandes, P A, Gräter, F, Hakobyan, D, Heuer, A, Karathanou, K, Keller, F, Lemieux, M J, Marrink, S J, May, E R, Mazumdar, A, Naftalin, R, Pickholz, M, Piotto, S, Pohl, P, Quinn, P, Ramos, M J, Schiøtt, B, Sengupta, D, Sessa, L, Vanni, S, Zeppelin, T, Zoni, V, Bondar, A N & Domene, C 2018, ' Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology ', Journal of Membrane Biology, vol. 251, no. 5-6, pp. 609-631 . https://doi.org/10.1007/s00232-018-0050-y
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The Journal of Membrane Biology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The Journal of Membrane Biology
This is a perspective article entitled “Frontiers in computational biophysics: understanding conformational dynamics of complex lipid mixtures relevant to biology” which is following a CECAM meeting with the same name. Fil: Friedman, Ran. Linnæu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d5c9e68c7426479035d0f27af9de39
https://hdl.handle.net/11370/358e5f81-077d-43c5-9ee5-4121558e6b5b
https://hdl.handle.net/11370/358e5f81-077d-43c5-9ee5-4121558e6b5b
Publikováno v:
Scientific Reports
Zeppelin, T, Pedersen, K B, Berglund, N A, Periole, X & Schiøtt, B 2021, ' Effect of palmitoylation on the dimer formation of the human dopamine transporter ', Scientific Reports, vol. 11, 4164 . https://doi.org/10.1038/s41598-021-83374-y
Zeppelin, T, Pedersen, K B, Berglund, N A, Periole, X & Schiøtt, B 2021, ' Effect of palmitoylation on the dimer formation of the human dopamine transporter ', Scientific Reports, vol. 11, no. 1, 4164 . https://doi.org/10.1038/s41598-021-83374-y
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Zeppelin, T, Pedersen, K B, Berglund, N A, Periole, X & Schiøtt, B 2021, ' Effect of palmitoylation on the dimer formation of the human dopamine transporter ', Scientific Reports, vol. 11, 4164 . https://doi.org/10.1038/s41598-021-83374-y
Zeppelin, T, Pedersen, K B, Berglund, N A, Periole, X & Schiøtt, B 2021, ' Effect of palmitoylation on the dimer formation of the human dopamine transporter ', Scientific Reports, vol. 11, no. 1, 4164 . https://doi.org/10.1038/s41598-021-83374-y
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The human dopamine transporter (hDAT) is one in three members of the monoamine transporter family (MAT). hDAT is essential for regulating the dopamine concentration in the synaptic cleft through dopamine reuptake into the presynaptic neuron; thereby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6a337b2348fc059b7586734f182bca
http://europepmc.org/articles/PMC7893171
http://europepmc.org/articles/PMC7893171
Autor:
Helgi I. Ingólfsson, Harsh Bhatia, Kristy A. Carpenter, Peer-Timo Bremer, Talia Zeppelin, W. F. Drew Bennett, Gautham Dharuman, Pin-Chia Hsu, Felice C. Lightstone, Birgit Schiøtt, Timothy S. Carpenter
Publikováno v:
Ingólfsson, H I, Bhatia, H, Zeppelin, T, Bennett, W F D, Carpenter, K A, Hsu, P C, Dharuman, G, Bremer, P T, Schiøtt, B, Lightstone, F C & Carpenter, T S 2020, ' Capturing Biologically Complex Tissue-Specific Membranes at Different Levels of Compositional Complexity ', The journal of physical chemistry. B, vol. 124, no. 36, pp. 7819-7829 . https://doi.org/10.1021/acs.jpcb.0c03368
The Journal of Physical Chemistry. B
The Journal of Physical Chemistry. B
Plasma membranes (PMs) contain hundreds of different lipid species that contribute differently to overall bilayer properties. By modulation of these properties, membrane protein function can be affected. Furthermore, inhomogeneous lipid mixing and do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b94290ba4305e92308fc4131637060
https://pure.au.dk/portal/da/publications/capturing-biologically-complex-tissuespecific-membranes-at-different-levels-of-compositional-complexity(8727b7f8-4ef5-48dd-9400-3f8470d181d8).html
https://pure.au.dk/portal/da/publications/capturing-biologically-complex-tissuespecific-membranes-at-different-levels-of-compositional-complexity(8727b7f8-4ef5-48dd-9400-3f8470d181d8).html
Publikováno v:
Zeppelin, T, Ladefoged, L K, Sinning, S & Schiøtt, B 2019, ' Substrate and inhibitor binding to the serotonin transporter : Insights from computational, crystallographic, and functional studies ', Neuropharmacology, vol. 161, 107548 . https://doi.org/10.1016/j.neuropharm.2019.02.030
Zeppelin, T, Ladefoged, L K, Sinning, S & Schiøtt, B 2019, ' Substrate and inhibitor binding to the serotonin transporter : Insights from computational, crystallographic, and functional studies ' Neuropharmacology . https://doi.org/10.1016/j.neuropharm.2019.02.030
Zeppelin, T, Ladefoged, L K, Sinning, S & Schiøtt, B 2019, ' Substrate and inhibitor binding to the serotonin transporter : Insights from computational, crystallographic, and functional studies ' Neuropharmacology . https://doi.org/10.1016/j.neuropharm.2019.02.030
The serotonin transporter (SERT) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. SERT is essential for regulating serotonergic signaling by the reuptake of serotonin from the synaptic cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f45ed5200494fec94f8eadcb8b9b9c
https://pure.au.dk/portal/da/publications/substrate-and-inhibitor-binding-to-the-serotonin-transporter(170d151a-a2d7-46c0-9ee9-d8245a8c16b0).html
https://pure.au.dk/portal/da/publications/substrate-and-inhibitor-binding-to-the-serotonin-transporter(170d151a-a2d7-46c0-9ee9-d8245a8c16b0).html
Publikováno v:
Zeppelin, T, Ladefoged, L K, Sinning, S, Periole, X & Schiøtt, B 2018, ' A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition ', PLOS Computational Biology, vol. 14, no. 1, e1005907 . https://doi.org/10.1371/journal.pcbi.1005907
PLoS Computational Biology, Vol 14, Iss 1, p e1005907 (2018)
PLoS Computational Biology
PLoS Computational Biology, Vol 14, Iss 1, p e1005907 (2018)
PLoS Computational Biology
Monoamine transporters (MATs) carry out neurotransmitter reuptake from the synaptic cleft, a key step in neurotransmission, which is targeted in the treatment of neurological disorders. Cholesterol (CHOL), a major component of the synaptic plasma mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a010bc87097a0f4c165f140b417f92ed
https://pure.au.dk/ws/files/121697211/zeppelin_a_direct_interaciton.pdf
https://pure.au.dk/ws/files/121697211/zeppelin_a_direct_interaciton.pdf
Publikováno v:
Scientific Reports
Periole, X, Zeppelin, T & Schiøtt, B 2018, ' Dimer Interface of the Human Serotonin Transporter and Effect of the Membrane Composition ', Scientific Reports, vol. 8, no. 1, 22912 . https://doi.org/10.1038/s41598-018-22912-7
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Periole, X, Zeppelin, T & Schiøtt, B 2018, ' Dimer Interface of the Human Serotonin Transporter and Effect of the Membrane Composition ', Scientific Reports, vol. 8, no. 1, 22912 . https://doi.org/10.1038/s41598-018-22912-7
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
The oligomeric state of membrane proteins has recently emerged in many cases as having an effect on their function. However, the intrinsic dynamics of their spatial organization in cells and model systems makes it challenging to characterize. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f432b1a74d9fac443dd89f72c1a6fb4
https://pubmed.ncbi.nlm.nih.gov/29572541
https://pubmed.ncbi.nlm.nih.gov/29572541
Autor:
Ina Pöhner, Flavio Di Pisa, Talia Zeppelin, Francesca Spyrakis, Stefano Mangani, Alberto Venturelli, Maria Paola Costi, Antonio Quotadamo, Alessio Bonucci, Rebecca C. Wade, Joanna Panecka-Hofman, Lucia Dello Iacono
Background Multi-target approaches are necessary to properly analyze or modify the function of a biochemical pathway or a protein family. An example of such a problem is the repurposing of the known human anti-cancer drugs, antifolates, as selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3329f9b96efeb212e0b58939c2f5f01b
http://hdl.handle.net/11365/1033685
http://hdl.handle.net/11365/1033685