A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference.

Autor: Philippa M Beard, Samantha J Griffiths, Orland Gonzalez, Ismar R Haga, Tali Pechenick Jowers, Danielle K Reynolds, Jan Wildenhain, Hille Tekotte, Manfred Auer, Mike Tyers, Peter Ghazal, Ralf Zimmer, Jürgen Haas

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98431 (2014)

Vaccinia virus (VACV) is a large, cytoplasmic, double-stranded DNA virus that requires complex interactions with host proteins in order to replicate. To explore these interactions a functional high throughput small interfering RNA (siRNA) screen targ

Externí odkaz: https://doaj.org/article/54e0675f17ff4ff48133bcd1756b2464

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry

Autor: Tali Pechenick Jowers, Samantha J. Griffiths, Juergen Haas, Ismar R. Haga, Philippa M. Beard

Publikováno v: Journal of Virology
Haga, I R, Pechenick Jowers, T, Griffiths, S J, Haas, J & Beard, P M 2014, ' TRAF2 facilitates Vaccinia virus replication by promoting rapid virus entry. ', Journal of Virology, vol. 88, no. 7, pp. 3664-3677 . https://doi.org/10.1128/JVI.03013-13

Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) is a pivotal intracellular mediator of signaling pathways downstream of TNFR1 and -2 with known pro- and antiviral effects. We investigated its role in the replication of the prototype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267618013bf844b8b353ea5b1d0fe3ff
https://doi.org/10.1128/jvi.03013-13

A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference

Autor: Hille Tekotte, Danielle K. Reynolds, Mike Tyers, Ralf Zimmer, Samantha J. Griffiths, Tali Pechenick Jowers, Jan Wildenhain, Manfred Auer, Orland Gonzalez, Philippa M. Beard, Peter Ghazal, Ismar R. Haga, Jürgen Haas

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e98431 (2014)
Beard, P M, Griffiths, S J, Gonzalez, O, Haga, I R, Pechenick-Jowers, T, Reynolds, D K, Wildenhain, J, Tekotte, H, Auer, M, Tyers, M, Ghazal, P, Zimmer, R & Haas, J 2014, ' A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference ', PLoS ONE, vol. 9, no. 6, e98431 . https://doi.org/10.1371/journal.pone.0098431

Vaccinia virus (VACV) is a large, cytoplasmic, double-stranded DNA virus that requires complex interactions with host proteins in order to replicate. To explore these interactions a functional high throughput small interfering RNA (siRNA) screen targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb130e9bbc53241951965c55a748ee96

Viral Mediated Redirection of NEMO/IKKγ to Autophagosomes Curtails the Inflammatory Cascade

Autor: Barbara Holstermann, Paul Dickinson, Wolfram Brune, Tali Pechenick Jowers, Claudia Mack, Peter Ghazal, Heinrich Hohenberg, Melanie M. Brinkmann, Patricia M. Fliss

Publikováno v: Fliss, P M, Jowers, T P, Brinkmann, M M, Holstermann, B, Mack, C, Dickinson, P, Hohenberg, H, Ghazal, P & Brune, W 2012, ' Viral Mediated Redirection of NEMO/IKKγ to Autophagosomes Curtails the Inflammatory Cascade ', PLoS Pathogens, vol. 8, no. 2, e1002517, pp. 1-14 . https://doi.org/10.1371/journal.ppat.1002517
PLoS Pathogens
PLoS Pathogens, Vol 8, Iss 2, p e1002517 (2012)

The early host response to viral infections involves transient activation of pattern recognition receptors leading to an induction of inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα). Subsequent activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8833312810b9060c7a551acebcabdcbe
https://www.pure.ed.ac.uk/ws/files/1405400/Fliss_et_al_2012.pdf