Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tali Lavy"'
Autor:
Inbal Maniv, Mahasen Sarji, Anwar Bdarneh, Alona Feldman, Roi Ankawa, Elle Koren, Inbar Magid-Gold, Noa Reis, Despina Soteriou, Shiran Salomon-Zimri, Tali Lavy, Ellina Kesselman, Naama Koifman, Thimo Kurz, Oded Kleifeld, Daniel Michaelson, Fred W. van Leeuwen, Bert M. Verheijen, Yaron Fuchs, Michael H. Glickman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is characterized by toxic protein accumulation in the brain. Ubiquitination is essential for protein clearance in cells, making altered ubiquitin signaling crucial in AD development. A defective variant, ubiquitin
Externí odkaz:
https://doaj.org/article/74e57d7f81c342d092153d856a153d11
Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that remodels the extracellular matrix and has been implicated as a major driver in cancer metastasis. Hence, there is a high demand for MMP-9 inhibitors for therapeutic purposes. For such drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b80f6eca77c35fb910cefb41f3d711
https://doi.org/10.1101/2023.04.11.536383
https://doi.org/10.1101/2023.04.11.536383
Proteasomes are multi-subunit, multi-catalytic protein complexes present in eukaryotic cells that degrade misfolded, damaged, or unstructured proteins. In this study, we used an activity-guided proteomic methodology based on fluorogenic peptide subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f79f081ee19814eb7350d4bf4c6ecdc
https://doi.org/10.1101/2023.03.30.534963
https://doi.org/10.1101/2023.03.30.534963
Autor:
Sheila Roitman, Andrey Rozenberg, Tali Lavy, Corina P. D. Brussaard, Oded Kleifeld, Oded Béjà
Virophages are small double stranded DNA (dsDNA) viruses that can only replicate in a host by co-infecting with another virus. Marine algae are commonly associated with virophage-like elements such as Polinton-like viruses (PLVs) that remain largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d43dcefecfbe09492a82e5b80995f44
https://www.vliz.be/imisdocs/publications/98/386798.pdf
https://www.vliz.be/imisdocs/publications/98/386798.pdf
Publikováno v:
Molecular & Cellular Proteomics. :100584
SummaryThe N-termini of proteins contain information about their biochemical properties and functions. These N-termini can be processed by proteases and can undergo other co- or post-translational modifications. We have developed LATE (LysN Amino Ter
Autor:
Sheila Roitman, Andrey Rozenberg, Tali Lavy, Corina P. D. Brussaard, Oded Kleifeld, Oded Béjà
Virophages are small dsDNA viruses dependent on a nucleocytoplasmic large-DNA virus infection of a cellular host for replication. Putative virophages infecting algal hosts are classified together with polinton-like viruses, transposable elements wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c08e18f873018f0bea82421ea72671
https://doi.org/10.1101/2022.07.28.501842
https://doi.org/10.1101/2022.07.28.501842
Publikováno v:
The Journal of Biological Chemistry
The ubiquitin (Ub)-proteasome system is the primary mechanism for maintaining protein homeostasis in eukaryotes, yet the underlying signaling events and specificities of its components are poorly understood. Proteins destined for degradation are tagg
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 63:o89-o92
The crystal structures of two cocrystals composed of 4,4′-(fluorene-9,9-diyl)diphenol (C25H18O2) and 6-methyl-2H-pyridone (C6H7NO) are reported, namely 4,4′-(fluorene-9,9-diyl)diphenol–6-methyl-2H-pyridone (1/2), C25H18O2·2C6H7NO, (I), and
Publikováno v:
Molecular biology and evolution. 33(2)
Derived from the yeast whole-genome duplication, Saccharomyces cerevisiae GAL1 and GAL3 encode the catabolic enzyme galactokinase (Gal1) and its transcriptional coinducer (Gal3), whereas the ancestral, preduplicated GAL1 gene performed both functions