Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tali Gidalevitz"'
Autor:
Suraiya Haroon, Annie Li, Jaye L. Weinert, Clark Fritsch, Nolan G. Ericson, Jasmine Alexander-Floyd, Bart P. Braeckman, Cole M. Haynes, Jason H. Bielas, Tali Gidalevitz, Marc Vermulst
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3115-3125 (2018)
Summary: Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and disease. Thus far, it has proven difficult to develop successful treatment strategies for diseases that are caused by mtDNA instability. To ad
Externí odkaz:
https://doaj.org/article/e47d4bd8404e4635af6f2b6acddc8c1f
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000196 (2019)
Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis. Anticipatory activation of the unfolded protein response (UPR) prepares cells for the onset of secretory function b
Externí odkaz:
https://doaj.org/article/05b0915ef8cc4d11ae2062a079fd4091
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006450 (2016)
Misfolded proteins in transgenic models of conformational diseases interfere with proteostasis machinery and compromise the function of many structurally and functionally unrelated metastable proteins. This collateral damage to cellular proteins has
Externí odkaz:
https://doaj.org/article/057f74f4d7bc4dbaa6c79b54128342cc
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000399 (2009)
Genetic background exerts a strong modulatory effect on the toxicity of aggregation-prone proteins in conformational diseases. In addition to influencing the misfolding and aggregation behavior of the mutant proteins, polymorphisms in putative modifi
Externí odkaz:
https://doaj.org/article/09fecd37127a403a872310609e584d01
Autor:
Valerie Bracchi-Ricard, Kayla Nguyen, Daniela Ricci, Brian Gaudette, Jorge Henao-Meija, Roberta Brambilla, Tetyana Martynyuk, Tali Gidalevitz, David Allman, John R. Bethea, Yair Argon
Publikováno v:
bioRxiv
Activation of the ER stress sensor IRE1α contributes to neuronal development and is known to induce neuronal remodelingin vitroandin vivo. On the other hand, excessive IRE1 activity is often detrimental and may contribute to neurodegeneration. To de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6ef9c3e3d25760780e637362815195
https://europepmc.org/articles/PMC10153167/
https://europepmc.org/articles/PMC10153167/
Autor:
Erin Munkáscy, Alfred L. Fisher, Tali Gidalevitz, James D. Lechleiter, Maruf Khan, Courtney Carroll Alexander, Tamara Fraker, Karl A. Rodriguez, Haven Tillmon, Habil Zare, Jessica Scheirer, Damian Lozano, Deborah M. Holstein
Publikováno v:
The Journals of Gerontology: Series A. 77:268-275
To explore the role of the small heat shock protein beta 1 (HspB1, also known as Hsp25 in rodents and Hsp27 in humans) in longevity, we created a Caenorhabiditis elegans model with a high level of ubiquitous expression of the naked mole-rat HspB1 pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10a64be53632d9f04297168d41993c6
https://doi.org/10.1093/gerona/glab296
https://doi.org/10.1093/gerona/glab296
Autor:
J. Alexander-Floyd, Tali Gidalevitz, Mingjie Ying, Cilia Jaeger, A. A. Entezari, Marc Vermulst, Suraiya Haroon
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
BMC Biology
BMC Biology
Background Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872a0faa07fb9e5d0ffad4aa35249a78
http://link.springer.com/article/10.1186/s12915-020-0750-5
http://link.springer.com/article/10.1186/s12915-020-0750-5
Publikováno v:
Immunological reviewsREFERENCES. 303(1)
The high rate of antibody production places considerable metabolic and folding stress on plasma cells (PC). Not surprisingly, they rely on the unfolded protein response (UPR), a universal signaling, and transcriptional network that monitors the healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d25539810c64ad2003a31d9ec629929
https://pubmed.ncbi.nlm.nih.gov/34368957
https://pubmed.ncbi.nlm.nih.gov/34368957
Autor:
Tali Gidalevitz, Adrienne W. Paton, Ravi Radhakrishnan, Stephen Tutton, James C. Paton, Ilaria Marrocco, Chih-Hang Anthony Tang, Yair Argon, Krishna Suresh, Chih-Chi Andrew Hu, Daniel M. Blumenthal, Daniela Eletto, Hossein Fazelinia, Daniela Ricci, Mingjie Ying, Deanne Taylor, Sarah Boyle, Lei Qian, Jade Vargas
Publikováno v:
The Journal of Biological Chemistry
The unfolded protein response plays an evolutionarily conserved role in homeostasis, and its dysregulation often leads to human disease, including diabetes and cancer. IRE1α is a major transducer that conveys endoplasmic reticulum stress via biochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8721b166fa2b7df7464ce116ac50595
http://hdl.handle.net/11386/4797929
http://hdl.handle.net/11386/4797929
Autor:
Daniela Ricci, Yair Argon, Stephen Tutton, Davide Eletto, Anthony Tang C, Tali Gidalevitz, Andrew Hu C, Adrienne W. Paton, Daniel M. Blumenthal, James C. Paton, Hossein Fazelinia, Mingjie Ying, Sarah Boyle, Jade Vargas, Ilaria Marrocco
The unfolded protein response (UPR) plays an evolutionarily conserved role in homeostasis, and its dysregulation often leads to human disease, including diabetes and cancer. IRE1α is a major transducer that conveys endoplasmic reticulum (ER) stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5485149822b9fef81861320b13fa31f7