Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Tali E. Haran"'
Autor:
Qiang Zhang, Dimitrios-Ilias Balourdas, Bruno Baron, Alon Senitzki, Tali E. Haran, Klas G. Wiman, Thierry Soussi, Andreas C. Joerger
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract The extremophile Alvinella pompejana, an annelid worm living on the edge of hydrothermal vents in the Pacific Ocean, is an excellent model system for studying factors that govern protein stability. Low intrinsic stability is a crucial factor
Externí odkaz:
https://doaj.org/article/6293f38a3c7d4577850a7e1f3760078f
Autor:
Jessy Safieh, Vasundhara Sharma, Yael Danin-Poleg, Tali E. Haran, Dmitrij Golovenko, Alon Senitzki, Alberto Inga
Publikováno v:
Nucleic Acids Research
Sequence-specific protein-DNA interactions are at the heart of the response of the tumor-suppressor p53 to numerous physiological and stress-related signals. Large variability has been previously reported in p53 binding to and transactivating from p5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14adf47b7843db7dacec5228bcaa771e
http://europepmc.org/articles/PMC7897521
http://europepmc.org/articles/PMC7897521
Autor:
Tali E. Haran, Thorsten Stiewe
Publikováno v:
Drug Resistance Updates. 38:27-43
The tumor suppressive transcription factor p53 regulates a wide array of cellular processes that confer upon cells an essential protection against cancer development. Wild-type p53 regulates gene expression by directly binding to DNA in a sequence-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af922e35999ab12e2488927f99f52ac2
https://doi.org/10.1016/j.drup.2018.05.001
https://doi.org/10.1016/j.drup.2018.05.001
Autor:
Zippora Shakked, Itai Beno, Zhiqun Xi, Naama Kessler, Tali E. Haran, Varda Rotter, Dmitrij Golovenko, Pratik Vyas, Yan Stein
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10624-10629
The tumor suppressor protein p53 acts as a transcription factor, binding sequence-specifically to defined DNA sites, thereby activating the expression of genes leading to diverse cellular outcomes. Canonical p53 response elements (REs) are made of tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6e8cc78cffee4a1a3e873fdf75db61
https://doi.org/10.1073/pnas.1618005114
https://doi.org/10.1073/pnas.1618005114
Autor:
Raul E. Salinas, Gregory M.K. Poon, Mimi Fang, Zachery Mielko, Suela Xhani, Alon Senitzki, Hashim M. Al-Hashimi, Maria A. Schumacher, Miles A. Pufall, Atul Rangadurai, Tali E. Haran, Honglue Shi, Raluca Gordân, Harshit Sahay, Ariel Afek
Publikováno v:
Nature
Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1e7de883a8dab8a462a4549cee163b
https://pubmed.ncbi.nlm.nih.gov/33087865
https://pubmed.ncbi.nlm.nih.gov/33087865
Autor:
Dmitrij Golovenko, Haim Rozenberg, Zippora Shakked, Tali E. Haran, Bastian Bräuning, Pratik Vyas
Publikováno v:
Structure (London, England : 1993). 26(9)
The tumor suppressor p53 acts as a transcription factor recognizing diverse DNA response elements (REs). Previous structural studies of p53-DNA complexes revealed non-canonical Hoogsteen geometry of A/T base pairs at conserved CATG motifs leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11717aba7e928d999f30d65bb46f40
https://pubmed.ncbi.nlm.nih.gov/30184478
https://pubmed.ncbi.nlm.nih.gov/30184478
Autor:
Marko Ušaj, Arnon Henn, Hanan Khoury-Haddad, Prathamesh T Nadar-Ponniah, Yael Mandel-Gutfreund, Nabieh Ayoub, Muhammad Zoabi, Tali E. Haran, Inbal Budowski-Tal
Publikováno v:
Nucleic Acids Research
The JmjC-containing lysine demethylase, KDM4D, demethylates di-and tri-methylation of histone H3 on lysine 9 (H3K9me3). How KDM4D is recruited to chromatin and recognizes its histone substrates remains unknown. Here, we show that KDM4D binds RNA inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4ec99abb00130ca3c1560a542c8564
https://doi.org/10.1093/nar/gku1021
https://doi.org/10.1093/nar/gku1021
Autor:
Daniel Menendez, Jennifer J. Jordan, Itai Beno, Tali E. Haran, Karin Rosenthal, Michael A. Resnick, Jenia Sharav
Publikováno v:
Proceedings of the National Academy of Sciences. 109:14387-14392
Transcriptional activation by the tumor suppressor p53 is considered to depend on cellular level, although there are few systems where this dependence on cellular level of p53 has been directly addressed. Previously, we reported that transactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf4313a90c02c773d23c22e1e6ea5d1
https://doi.org/10.1073/pnas.1205971109
https://doi.org/10.1073/pnas.1205971109
Publikováno v:
Nucleic Acids Research
The prime mechanism by which p53 acts as a tumor suppressor is as a transcription factor regulating the expression of diverse downstream genes. The DNA-binding domain of p53 (p53DBD) interacts with defined DNA sites and is the main target for mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cf79c8806645d955e72b3ef75a52e9
https://doi.org/10.1093/nar/gkq1044
https://doi.org/10.1093/nar/gkq1044
Autor:
Tali E. Haran, Udayan Mohanty
Publikováno v:
Quarterly Reviews of Biophysics. 42:41-81
Short runs of adenines are a ubiquitous DNA element in regulatory regions of many organisms. When runs of 4–6 adenine base pairs (‘A-tracts’) are repeated with the helical periodicity, they give rise to global curvature of the DNA double helix,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155ccd43844bffe941ddf9545c1040a5
https://doi.org/10.1017/s0033583509004752
https://doi.org/10.1017/s0033583509004752