d-Glutamate production by stressed Escherichia coli gives a clue for the hypothetical induction mechanism of the ALS disease

Autor: Edna Ben-Izhak Monselise, Maria Vyazmensky, Tali Scherf, Albert Batushansky, Itzhak Fishov

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract In the search for the origin of Amyotrophic Lateral Sclerosis disease (ALS), we hypothesized earlier (Monselise, 2019) that d-amino acids produced by stressed microbiome may serve as inducers of the disease development. Many examples of d-am

Externí odkaz: https://doaj.org/article/6ea5217ce85e443d9ae3b8e6c974da5a

Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases

Autor: Pablo D. Cárdenas, Prashant D. Sonawane, Uwe Heinig, Adam Jozwiak, Sayantan Panda, Bekele Abebie, Yana Kazachkova, Margarita Pliner, Tamar Unger, Dalia Wolf, Itai Ofner, Ester Vilaprinyo, Sagit Meir, Olga Davydov, Amit Gal-on, Saul Burdman, Ashok Giri, Dani Zamir, Tali Scherf, Jedrzej Szymanski, Ilana Rogachev, Asaph Aharoni

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Steroidal glycoalkaloids (SGAs) accumulate in Solanum, but their hydroxylating enzymes are unknown. Here, the authors report 2-OXOGLUTARATE DEPENDENT DIOXYGENASE enzymes that catalyze the committed hydroxylation steps in the biosynthesis of leptinine

Externí odkaz: https://doaj.org/article/9c9712e24c4a476fbbcb98c2daa326a1

Polyamines Mediate Folding of Primordial Hyperacidic Helical Proteins

Autor: Liam M. Longo, Dragana Despotovic, Dan S. Tawfik, Tali Scherf, Einav Aharon, Ita Gruić-Sovulj, Amit Kahana

Publikováno v: Biochemistry

Polyamines are known to mediate diverse biological processes, and specifically to bind and stabilize compact conformations of nucleic acids, acting as chemical chaperones that promote folding by offsetting the repulsive negative charges of the phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b4a3b366ecb3619ed0c2c393f05d02
https://doi.org/10.1021/acs.biochem.0c00800

Magnetization Transfer to Enhance NOE Cross‐Peaks among Labile Protons: Applications to Imino–Imino Sequential Walks in SARS‐CoV‐2‐Derived RNAs

Autor: Andreas Oxenfarth, Mihajlo Novakovic, Robbin Schnieders, Eriks Kupče, Tali Scherf, Harald Schwalbe, J Tassilo Grün, Julia Wirmer-Bartoschek, Christian Richter, Lucio Frydman

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)

2D NOESY plays a central role in structural NMR spectroscopy. We have recently discussed methods that rely on solvent‐driven exchanges to enhance NOE correlations between exchangeable and non‐exchangeable protons in nucleic acids. Such methods, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773193e7ee738be4afbc17be4e81cfbf

Correction to ‘Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy’

Autor: Anna Wacker, Julia E Weigand, Sabine R Akabayov, Nadide Altincekic, Jasleen Kaur Bains, Elnaz Banijamali, Oliver Binas, Jesus Castillo-Martinez, Erhan Cetiner, Betül Ceylan, Liang-Yuan Chiu, Jesse Davila-Calderon, Karthikeyan Dhamotharan, Elke Duchardt-Ferner, Jan Ferner, Lucio Frydman, Boris Fürtig, José Gallego, J Tassilo Grün, Carolin Hacker, Christina Haddad, Martin Hähnke, Martin Hengesbach, Fabian Hiller, Katharina F Hohmann, Daniel Hymon, Vanessa de Jesus, Henry Jonker, Heiko Keller, Bozana Knezic, Tom Landgraf, Frank Löhr, Le Luo, Klara R Mertinkus, Christina Muhs, Mihajlo Novakovic, Andreas Oxenfarth, Martina Palomino-Schätzlein, Katja Petzold, Stephen A Peter, Dennis J Pyper, Nusrat S Qureshi, Magdalena Riad, Christian Richter, Krishna Saxena, Tatjana Schamber, Tali Scherf, Judith Schlagnitweit, Andreas Schlundt, Robbin Schnieders, Harald Schwalbe, Alvaro Simba-Lahuasi, Sridhar Sreeramulu, Elke Stirnal, Alexey Sudakov, Jan-Niklas Tants, Blanton S Tolbert, Jennifer Vögele, Lena Weiß, Julia Wirmer-Bartoschek, Maria A Wirtz Martin, Jens Wöhnert, Heidi Zetzsche

Publikováno v: Nucleic Acids Research

The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ad3a3468b5df3796b23f6db66b8ffd
https://doi.org/10.1093/nar/gkab568