Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator.

Autor: Thomson CG; Integrated Drug Discovery Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K., Aicher TD; Department of Chemistry, Lycera Corporation, Ann Arbor, Michigan 48103, United States., Cheng W; Pharmaron Beijing, Company Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, China., Du H; Pharmaron Beijing, Company Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, China., Dudgeon C; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Li AH; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Li B; Pharmaron Beijing, Company Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, China., Lightcap E; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Luo D; Pharmaron Xi'an, Company Ltd., No. 1, 12th Fengcheng Road, Xi'an 710018, China., Mulvihill M; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Pan P; Pharmaron Beijing, Company Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, China., Rahemtulla BF; Integrated Drug Discovery Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K., Rigby AC; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Sherborne B; Integrated Drug Discovery Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K., Sood S; Preformulation and Preclinical Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K., Surguladze D; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Talbot EPA; Integrated Drug Discovery Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K., Tameire F; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Taylor S; Integrated Drug Discovery Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K., Wang Y; Pharmaron Beijing, Company Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, China., Wojnarowicz P; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States., Xiao F; Pharmaron Xi'an, Company Ltd., No. 1, 12th Fengcheng Road, Xi'an 710018, China., Ramurthy S; HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Apr 11; Vol. 67 (7), pp. 5259-5271. Date of Electronic Publication: 2024 Mar 26.

Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles.

Autor: Turner OJ; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.; Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK., Murphy JA; Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK., Hirst DJ; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK., Talbot EPA; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.; Present address: Pharmaron, Hertford Rd, Hoddesdon, EN11 9BU, UK.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2018 Dec 12; Vol. 24 (70), pp. 18658-18662. Date of Electronic Publication: 2018 Nov 12.

Oxidative β-C-H sulfonylation of cyclic amines.

Autor: Griffiths RJ; GlaxoSmithKline Medicines Research , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , UK.; Department of Pure and Applied Chemistry , University of Strathclyde , 295 Cathedral Street , Glasgow , G1 1XL , UK., Kong WC; GlaxoSmithKline Medicines Research , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , UK.; Department of Chemistry , University of Oxford , CRL Mansfield Road , Oxford , OX1 3TA , UK . Email: michael.willis@chem.ox.ac.uk., Richards SA; GlaxoSmithKline Medicines Research , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , UK., Burley GA; Department of Pure and Applied Chemistry , University of Strathclyde , 295 Cathedral Street , Glasgow , G1 1XL , UK., Willis MC; Department of Chemistry , University of Oxford , CRL Mansfield Road , Oxford , OX1 3TA , UK . Email: michael.willis@chem.ox.ac.uk., Talbot EPA; GlaxoSmithKline Medicines Research , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , UK.

Publikováno v: Chemical science [Chem Sci] 2018 Jan 22; Vol. 9 (8), pp. 2295-2300. Date of Electronic Publication: 2018 Jan 22 (Print Publication: 2018).

The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes.

Autor: Thornbury RT; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: fdtoste@berkeley.edu., Saini V; Novartis Institutes for Biomedical Research , Cambridge , Massachusetts 02139 , USA., Fernandes TA; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: fdtoste@berkeley.edu.; Instituto de Química , Universidade de Brasília , Campus Universitário Darcy Ribeiro , Caixa Postal: 04478 , 70904-970 , Brasília , DF , Brazil., Santiago CB; Department of Chemistry , University of Utah , Salt Lake City , Utah 84112 , USA., Talbot EPA; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: fdtoste@berkeley.edu.; Novartis Institutes for Biomedical Research , Cambridge , Massachusetts 02139 , USA., Sigman MS; Department of Chemistry , University of Utah , Salt Lake City , Utah 84112 , USA., McKenna JM; Novartis Institutes for Biomedical Research , Cambridge , Massachusetts 02139 , USA., Toste FD; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: fdtoste@berkeley.edu.

Publikováno v: Chemical science [Chem Sci] 2017 Apr 01; Vol. 8 (4), pp. 2890-2897. Date of Electronic Publication: 2017 Feb 09.