Zobrazeno 1 - 10 of 125 pro vyhledávání: '"Talampanel"'
1
Akademický článek
AMPAR receptor inhibitors suppress proliferation of human small cell lung cancer cell lines
Autor: Nami Masumoto, Shingo Kato, Masahiro Aichi, Sho Hasegawa, Kota Sahara, Kumiko Suyama, Akane Sano, Tomoyuki Miyazaki, Koji Okudela, Takeshi Kaneko, Takuya Takahashi
Publikováno v: Thoracic Cancer, Vol 14, Iss 29, Pp 2897-2908 (2023)
Abstract Background Small cell lung cancer (SCLC) is a neuroendocrine tumor with poor prognosis. Neuroendocrine tumors possess characteristics of both nerve cells and hormone‐secreting cells; therefore, targeting the neuronal properties of these tu
Externí odkaz: https://doaj.org/article/418c4c541dbf4c5191c29bc5273bfa0b
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2
Akademický článek
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3
Akademický článek
Protection from Fatal Viral Encephalomyelitis: AMPA Receptor Antagonists Have a Direct Effect on the Inflammatory Response to Infection
Autor: Greene, Ivorlyne P., Lee, Eun-Young, Prow, Natalie, Ngwang, Brownhilda, Griffin, Diane E.
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2008 Mar 01. 105(9), 3575-3580.
Externí odkaz: https://www.jstor.org/stable/25461276
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4
Talampanel as add-on therapy for the treatment of refractory partial epilepsy
Autor: Yue Cao, Jinou Zheng, Qin Zhou
Publikováno v: Cochrane Database Syst Rev
The Cochrane Library
This protocol for a Cochrane Review is out of date and has been withdrawn in order to adhere to Cochrane policy.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856d4554ee2b87ac4a70bbeeacb25dd3
https://doi.org/10.1002/14651858.cd010831.pub2
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5
Synthesis and Pharmacological Evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile Derivatives as Orally Active AMPA Receptor Antagonists
Autor: Masaaki Hirano, Kazushige Ohno, Jun-Ichi Shishikura, Takenori Kimura, Tomoyuki Yasunaga, Hiroshi Inami, Hiroshi Yamashita, Shuichi Sakamoto
Publikováno v: Chemical and Pharmaceutical Bulletin. 67:699-706
In our search for novel orally active α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, we found that conversion of an allyl group in the lead compound 2-[allyl(4-methylphenyl)amino]-4H-pyrido[3,2-e][1,3]thiazin-4-one
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e475c6e1e169b5d25934aacba33e548
https://doi.org/10.1248/cpb.c18-00977
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6
Akademický článek
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7
Molecular insights into the role of AMPA receptors in the synaptic plasticity, pathogenesis and treatment of epilepsy: therapeutic potentials of perampanel and antisense oligonucleotide (ASO) technology
Autor: Amin Karimi-Moghadam, M. Reza Jabalameli, Saeid Charsouei
Publikováno v: Acta neurologica Belgica. 120(3)
Glutamate is considered as the predominant excitatory neurotransmitter in the mammalian central nervous systems (CNS). Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are the main glutamate-gated ionotropic channels that m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6476b2eb3729742ba7e57708cf988234
https://pubmed.ncbi.nlm.nih.gov/32152997
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8
Química verde como foco na síntese do talampanel, do etomidato e de iodoarenos
Autor: Capeletto, Marina Gonçalves
Publikováno v: Repositório Institucional da UFABC
Universidade Federal do ABC (UFABC)
instacron:UFABC
Orientador: Prof. Dr. Álvaro Takeo Omori Tese (doutorado) - Universidade Federal do ABC, Programa de Pós-Graduação em Ciência e Tecnologia/Química, Santo André, 2019. A seguinte tese consistiu de três frentes de trabalho, tendo como foco a ap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::af4bf32ec12bf4befa504fa6c8fd457f
http://biblioteca.ufabc.edu.br/index.php?codigo_sophia=118912
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9
Potential Therapeutic Drugs and Methods for the Treatment of Amyotrophic Lateral Sclerosis
Autor: Youssef Sari, G Yacila
Publikováno v: Current Medicinal Chemistry. 21:3583-3593
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder caused by damage of motoneurons leading to paralysis state and long term disability. Riluzole is currently the only FDA-approved drug for the treatment of ALS. The proposed mechanism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378306016998e563ff7523fe6da9303c
https://doi.org/10.2174/0929867321666140601162710
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10
Presymptomatically applied AMPA receptor antagonist prevents calcium increase in vulnerable type of motor axon terminals of mice modeling amyotrophic lateral sclerosis
Autor: Caterina Bendotti, Roland Patai, Izabella Obál, József I. Engelhardt, László Siklós, Massimo Tortarolo, Melinda Paizs
Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1863(7)
Increased intracellular calcium (Ca), which might be the consequence of an excess influx through Ca-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, plays a crucial role in degeneration of motor neurons. Previously we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ced8b65968f78979bb69b753e992683
https://pubmed.ncbi.nlm.nih.gov/28528135
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