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Akademický článek

Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.

Autor: Ersheng Kuang, Cheryl Y M Okumura, Sharon Sheffy-Levin, Tal Varsano, Vincent Chih-Wen Shu, Jianfei Qi, Ingrid R Niesman, Huei-Jiun Yang, Carlos López-Otín, Wei Yuan Yang, John C Reed, Limor Broday, Victor Nizet, Ze'ev A Ronai

Publikováno v: PLoS Genetics, Vol 8, Iss 10, p e1003007 (2012)

Autophagy is the mechanism by which cytoplasmic components and organelles are degraded by the lysosomal machinery in response to diverse stimuli including nutrient deprivation, intracellular pathogens, and multiple forms of cellular stress. Here, we

Externí odkaz: https://doaj.org/article/8cd0cc7e2da7426d9f257e0e0de91174

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Akademický článek

The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.

Autor: Tal Varsano, Vanessa Taupin, Lixia Guo, Oscar Y Baterina, Marilyn G Farquhar

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49227 (2012)

Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors--LPA(1-6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown. W

Externí odkaz: https://doaj.org/article/fe6bf662327a4288a7b4a1fe0a144925

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Supplementary Tables S1 and S2 from Inhibition of Melanoma Growth by Small Molecules That Promote the Mitochondrial Localization of ATF2

Autor: Ze'ev A. Ronai, Christian A. Hassig, Susanne Heynen-Genel, Loribelle Milan, Marine Garrido, Yongmei Feng, Eric Lau, Tal Varsano

Supplementary Tables S1 and S2 - PDF file 100K, Supplementary Table S1. The top 20 upregulated genes in WM793 cells treated for 24 h with SBI-087702 as compared to DMSO-treated cells; Supplementary Table S2. The top 20 downregulated genes in WM793 ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf40b31def71a866f0df6242d267375
https://doi.org/10.1158/1078-0432.22446815

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Data from Inhibition of Melanoma Growth by Small Molecules That Promote the Mitochondrial Localization of ATF2

Autor: Ze'ev A. Ronai, Christian A. Hassig, Susanne Heynen-Genel, Loribelle Milan, Marine Garrido, Yongmei Feng, Eric Lau, Tal Varsano

Purpose: Effective therapy for malignant melanoma, the leading cause of death from skin cancer, remains an area of significant unmet need in oncology. The elevated expression of PKCϵ in advanced metastatic melanoma results in the increased phosphory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebbe400eaa3c589273627974cc6cae0
https://doi.org/10.1158/1078-0432.c.6520886.v1

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Supplementary Figures S1 - S6 from Inhibition of Melanoma Growth by Small Molecules That Promote the Mitochondrial Localization of ATF2

Autor: Ze'ev A. Ronai, Christian A. Hassig, Susanne Heynen-Genel, Loribelle Milan, Marine Garrido, Yongmei Feng, Eric Lau, Tal Varsano

Supplementary Figures S1 - S6 - PDF file 945K, Supplementary Figure S1. Effect of select compounds on ATF2 nuclear-mitochondrial Translocation; Supplementary Figure S2. SBI-0089410 or SBI-0087702 do not affect the subcellular localization of Stat3 or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb224659955a3338a43f2a1c43ab18e
https://doi.org/10.1158/1078-0432.22446821

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Correction: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection

Autor: Limor Broday, Huei-Jiun Yang, Ze'ev Ronai, Cheryl Y. M. Okumura, Ersheng Kuang, Tal Varsano, Wei Yuan Yang, Carlos López-Otín, Ingrid R. Niesman, Sharon Sheffy-Levin, Vincent Chih-Wen Shu, Victor Nizet, John C. Reed, Jianfei Qi

Publikováno v: PLoS Genetics, Vol 16, Iss 5, p e1008795 (2020)
PLoS Genetics, Vol 8, Iss 10, p e1003007 (2012)
PLoS Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afb84e1c293bc14ab4ad6726d8501b3
https://doi.org/10.1371/journal.pgen.1008795

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Degradation of Newly Synthesized Polypeptides by Ribosome-Associated RACK1/c-Jun N-Terminal Kinase/Eukaryotic Elongation Factor 1A2 Complex

Autor: Gustavo J. Gutierrez, Shannon McLaughlan, Pedro Aza-Blanc, Tal Varsano, Yongmei Feng, Nahum Sonenberg, Valentina Gandin, Tiago Ferreira, Qingyan Au, Ivan Topisirovic, Tommy Alain, Ze'ev Ronai, Laurence M. Brill

Publikováno v: Molecular and Cellular Biology. 33:2510-2526

Folding of newly synthesized polypeptides (NSPs) into functional proteins is a highly regulated process. Rigorous quality control ensures that NSPs attain their native fold during or shortly after completion of translation. Nonetheless, signaling pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83ec908feb1070e08278f5ffdff3a2c
https://doi.org/10.1128/mcb.01362-12

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PKCε Promotes Oncogenic Functions of ATF2 in the Nucleus while Blocking Its Apoptotic Function at Mitochondria

Autor: Harriet M. Kluger, Eric Lau, David L. Rimm, Trey Ideker, Ki-Young Lee, Ze'ev Ronai, Tal Varsano, Immo E. Scheffler

Publikováno v: Cell. 148:543-555

SummaryThe transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e3c6bc980198f97071e32287f431cb
https://doi.org/10.1016/j.cell.2012.01.016

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