Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tal Hirschhorn"'
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43459 (2012)
The response to transforming growth factor-β (TGF-β) depends on cellular context. This context is changed in mitosis through selective inhibition of vesicle trafficking, reduction in cell volume and the activation of mitotic kinases. We hypothesize
Externí odkaz:
https://doaj.org/article/91656b5199c94a189ab25783ff4cb54c
Autor:
Tal Hirschhorn, Brent R. Stockwell
Publikováno v:
Molecular Cell. 82:3760-3762
The dietary factor vitamin K has been found to protect against ferroptosis, a form of cell death driven by lipid peroxidation. This reveals new dietary links to cancers and degenerative conditions and a key factor involved in warfarin poisoning.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1e36724b1212485134b70f90b9ef02
https://doi.org/10.1016/j.molcel.2022.10.001
https://doi.org/10.1016/j.molcel.2022.10.001
Autor:
A. Nikolai von Krusenstiern, Ryan N. Robson, Naixin Qian, Baiyu Qiu, Fanghao Hu, Eduard Reznik, Nailah Smith, Fereshteh Zandkarimi, Verna M. Estes, Marcel Dupont, Tal Hirschhorn, Mikhail S. Shchepinov, Wei Min, K. A. Woerpel, Brent R. Stockwell
Publikováno v:
Nature Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::271233ae31c85ab11fd6e2c048f6cf68
https://doi.org/10.1038/s41589-022-01249-3
https://doi.org/10.1038/s41589-022-01249-3
Autor:
Michael E. Stokes, Jonnell Candice Small, Brent R. Stockwell, Andrea Califano, Kenichi Shimada, Tal Hirschhorn, Alessandro Vasciaveo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
The identification of targeted agents with high therapeutic index is a major challenge for cancer drug discovery. We found that screening chemical libraries across neuroblastoma (NBL) tumor subtypes for selectively-lethal compounds revealed metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c371ecfcc034bf32c8e283bb1f64fc9
https://doi.org/10.1038/s41598-020-67310-0
https://doi.org/10.1038/s41598-020-67310-0
Autor:
Dino Wu, Emily M. Churchill, Sungsoo Kim, Tal Hirschhorn, Hee Won Yang, Kealan J. Fallon, Luis M. Campos, Rinat Meir, Brent R. Stockwell
Publikováno v:
Advanced Functional Materials. 31:2010907
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916d0e79a3ec71eaffffb9703b68d476
https://doi.org/10.1002/adfm.202010907
https://doi.org/10.1002/adfm.202010907
Publikováno v:
Cellular and Molecular Life Sciences. 74:2645-2662
The Type-I bone morphogenetic protein receptors (BMPRs), BMPR1A and BMPR1B, present the highest sequence homology among BMPRs, suggestive of functional similitude. However, sequence elements within their extracellular domain, such as signal sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4883b8e568956c05992956256fcf8d
https://doi.org/10.1007/s00018-017-2488-y
https://doi.org/10.1007/s00018-017-2488-y
Autor:
Michael A. Badgley, Kenneth P. Olive, Zachary P. Tolstyka, Steve A. Sastra, Brent R. Stockwell, Jonathan Kapillian, Geoffrey M. Wahl, Ho-Joon Lee, Uri Manor, E. Scott Seeley, Irina Sagalovskiy, Daniel M. Kremer, Leonardo R. Andrade, Everett Stone, Amanda R. Decker, Kathleen E. DelGiorno, George Georgiou, H. Carlo Maurer, Li Zhang, Alice Ma, Tong Liu, Candice Lamb, Christina E. M. Firl, Carmine F. Palermo, Costas A. Lyssiotis, Wei Gu, Alina Iuga, Tal Hirschhorn, Vinee Purohit, Peter Sajjakulnukit
Pancreatic ductal adenocarcinoma (PDA) is the third-leading cause of cancer mortality in the US and is highly resistant to classical, targeted, and immune therapies. We show that human PDA cells are dependent on the provision of exogenous cystine to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3979aae84b9a417410ca41872a3a235
Autor:
H. Carlo Maurer, Irina Sagalovskiy, Daniel M. Kremer, Peter Sajjakulnukit, Geoffrey M. Wahl, Everett Stone, Steve A. Sastra, Uri Manor, Alina Iuga, Ho-Joon Lee, Christina E. M. Firl, Brent R. Stockwell, George Georgiou, Costas A. Lyssiotis, Kenneth P. Olive, Wei Gu, Li Zhang, Tal Hirschhorn, E. Scott Seeley, Alice Ma, Amanda R. Decker, Kathleen E. DelGiorno, Jonathan Kapilian, Vinee Purohit, Carmine F. Palermo, Tong Liu, Zachary P. Tolstyka, Leonardo R. Andrade, Candice Lamb, Michael A. Badgley
Publikováno v:
Science
Ferroptotic cell death and cancer Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment. One form of cell death that has attracted recent interest is ferroptosis, which is tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c3205b305fe64dbc25897295c26de4
https://pubmed.ncbi.nlm.nih.gov/32241947
https://pubmed.ncbi.nlm.nih.gov/32241947
Autor:
Keren E. Shapira, Petra Knaus, Yoav I. Henis, Livia Preisler, Marcelo Ehrlich, Ayelet R. Amsalem, Barak Marom, Tal Hirschhorn, Pia Paarmann
Publikováno v:
Molecular Biology of the Cell
The cytoplasmic extension of the long-form isoform of BMPRII, unique among TGF-β superfamily receptors, is found to regulate the translation of BMPRII and its clathrin-mediated endocytosis. Both processes reduce its cell surface levels. The higher e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3168a968a6d689dd33d63ec494fcb73f
https://doi.org/10.1091/mbc.e15-08-0547
https://doi.org/10.1091/mbc.e15-08-0547
Autor:
Tal Hirschhorn, Brent R. Stockwell
Publikováno v:
Free radical biologymedicine. 133
The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of cell death caused by the accumulation of lipid-based reactive oxygen species; this type of cell death was found to have molecular characteristics distinct from ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b32e133496f5fc2354e10cbb0aa959
https://pubmed.ncbi.nlm.nih.gov/31398500
https://pubmed.ncbi.nlm.nih.gov/31398500