Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Tal Danino"'
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Autor:
Candice R. Gurbatri, Georgette A. Radford, Laura Vrbanac, Jongwon Im, Elaine M. Thomas, Courtney Coker, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin R. M. Lannagan, Tongtong Wang, Josephine A. Wright, Hiroki Kobayashi, Jia Q. Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Alexandra M. Stavropoulos, Dion A. Gouskos, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L. Worthley, Susan L. Woods, Tal Danino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Niss
Externí odkaz:
https://doaj.org/article/16a3783ebc994816bc3440bb05df9c6f
Autor:
Filippo Liguori, Nicola Pellicciotta, Edoardo Milanetti, Sophia Xi Windemuth, Giancarlo Ruocco, Roberto Di Leonardo, Tal Danino
Publikováno v:
BioDesign Research, Vol 6 (2024)
Engineered bacteria have the potential to deliver therapeutic payloads directly to tumors, with synthetic biology enabling precise control over therapeutic release in space and time. However, it remains unclear how to optimize therapeutic bacteria fo
Externí odkaz:
https://doaj.org/article/0a6e96aa24a0420da497c7e26e1c901d
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/617bc9c4084d41e89d8a3208ebb8b1a6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Synthetic biology enables the engineering of bacteria to safely deliver potent payloads to tumors for effective anti-cancer therapies. However, a central challenge for translation is determining ideal bacterial therapy candidates for specifi
Externí odkaz:
https://doaj.org/article/1ea02c3efcf74f9cb07bea2d420aef0a
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Predicting patient responses to chemotherapy regimens is a major challenge in cancer treatment. Experimental model systems coupled with quantitative mathematical models to calculate optimal dose and frequency of drugs can enable improved chemotherapy
Externí odkaz:
https://doaj.org/article/0e6d675dfe6245bb9bca533fecf2b41b
Autor:
Alex J.H. Fedorec, Tanel Ozdemir, Anjali Doshi, Yan-Kay Ho, Luca Rosa, Jack Rutter, Oscar Velazquez, Vitor B. Pinheiro, Tal Danino, Chris P. Barnes
Publikováno v:
iScience, Vol 14, Iss , Pp 323-334 (2019)
Summary: Plasmids are the workhorse of both industrial biotechnology and synthetic biology, but ensuring they remain in bacterial cells is a challenge. Antibiotic selection cannot be used to stabilize plasmids in most real-world applications, and ins
Externí odkaz:
https://doaj.org/article/7fc97d305d384cc1b919e95418a68bcc
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Inflammatory intestinal diseases such as Crohn’s disease and ulcerative colitis have seen an increase in their prevalence in developing countries throughout the current decade. These are caused by a combination of genetic and environmental factors,
Externí odkaz:
https://doaj.org/article/6bf6fac492154e38ae31982c73871c88
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20182 (2011)
Cells organize in complex three-dimensional patterns by interacting with proteins along with the surrounding extracellular matrix. This organization provides the mechanical and chemical cues that ultimately influence a cell's differentiation and func
Externí odkaz:
https://doaj.org/article/6fb2a19848dd4d0b90668032b4d33579
Autor:
Anjali Doshi, Marian Shaw, Ruxandra Tonea, Soonhee Moon, Rosalía Minyety, Anish Doshi, Andrew Laine, Jia Guo, Tal Danino
Publikováno v:
Nature Chemical Biology.
Publikováno v:
Microbiology Spectrum. 11
Short-chain fatty acids are key molecules produced by the gut microbiome. Their concentrations are altered in certain diseases. Here, we created molecular biosensors that quantify the absence of propionate and butyrate, using logic “NOT” gates an