The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance

Autor: Sathish K. Murali, Takwa S. Aroankins, Hanne B. Moeller, Robert A. Fenton

Publikováno v: Cells, Vol 8, Iss 3, p 265 (2019)

Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis. VP effects on AQP2 occur via long-term alterations in AQP2 abundance and sh

Externí odkaz: https://doaj.org/article/0d5a190f0a3443de95db9beb7de03e70

The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance

Autor: Hanne B. Moeller, Takwa S. Aroankins, Sathish K. Murali, Robert A. Fenton

Publikováno v: Cells, Vol 8, Iss 3, p 265 (2019)
Cells
Volume 8
Issue 3
Murali, S K, Aroankins, T S, Moeller, H B & Fenton, R A 2019, ' The Deubiquitylase USP4 Interacts with the Water Channel AQP2 to Modulate Its Apical Membrane Accumulation and Cellular Abundance ', Cells, vol. 8, no. 3 . https://doi.org/10.3390/cells8030265

Aquaporin 2 (AQP2) mediates the osmotic water permeability of the kidney collecting duct in response to arginine vasopressin (VP) and is essential for body water homeostasis. VP effects on AQP2 occur via long-term alterations in AQP2 abundance and sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b557211793e13505ee6121025772092b
https://www.mdpi.com/2073-4409/8/3/265

Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ

Autor: Nanna MacAulay, Takwa S. Aroankins, Joachim Slengerik-Hansen, Vivek Bhalla, Mette Assentoft, Robert A. Fenton, S K Moestrup, Hanne B. Moeller

Publikováno v: Moeller, H B, Slengerik-Hansen, J, Aroankins, T, Assentoft, M, MacAulay, N, Moestrup, S K, Bhalla, V & Fenton, R A 2016, ' Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and-ζ ', Journal of Biological Chemistry, vol. 291, no. 5, pp. 2469-84 . https://doi.org/10.1074/jbc.M115.691121
Moeller, H B, Slengerik-Hansen, J, Aroankins, T, Assentoft, M, MacAulay, N, Moestrup, S K, Bhalla, V & Fenton, R A 2016, ' Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and-ζ ', Journal of Biological Chemistry, vol. 291, no. 5, pp. 2469-2484 . https://doi.org/10.1074/jbc.M115.691121

The 14-3-3 family of proteins are multifunctional proteins that interact with many of their cellular targets in a phosphorylation-dependent manner. Here, we determined that 14-3-3 proteins interact with phosphorylated forms of the water channel aquap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d97451ee82cbc7d73fd58ce4f0a416
https://pure.au.dk/portal/da/publications/regulation-of-the-water-channel-aquaporin2-via-1433-and-(670ee6f0-d3fc-421d-97c3-35544c61d9d6).html

Phosphorylation and ubiquitylation are opposing players in regulating endocytosis of the water channel Aquaporin-2

Autor: Joachim Slengerik-Hansen, Hanne B. Moeller, Trairak Pisitkun, Robert A. Fenton, Takwa S. Aroankins

Publikováno v: Journal of Cell Science.

The post-translational modifications (PTMs) phosphorylation and ubiquitylation regulate plasma membrane protein function. Here we examine interplay between phosphorylation and ubiquitylation of the membrane protein aquaporin-2 (AQP2) and demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b6ed46d3f7927e15019a328eda4f6b2
https://doi.org/10.1242/jcs.150680

SUMOylation Landscape of Renal Cortical Collecting Duct Cells

Autor: Lei Cheng, Takwa S. Aroankins, Robert A. Fenton, Qi Wu

Publikováno v: Wu, Q, Aroankins, T S, Cheng, L & Fenton, R A 2019, ' SUMOylation Landscape of Renal Cortical Collecting Duct Cells ', Journal of Proteome Research, vol. 18, no. 10, pp. 3640-3648 . https://doi.org/10.1021/acs.jproteome.9b00306
Journal of Proteome Research

Protein post-translational modification by the small ubiquitin-like modifier (SUMO) is a mechanism that allows a diverse response of cells to stress. Five SUMO family members, SUMO1-5, are expressed in mammals. We hypothesized that because kidney epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9a6a821609057864ba655b45f477ce