Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Takuya MIZUNO"'
Autor:
Shoma Nishibori, Mika K. Kaneko, Takayuki Nakagawa, Kazuo Nishigaki, Yukinari Kato, Masaya Igase, Takuya Mizuno
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Antibodies against immune checkpoint molecules restore T-cell function by inhibiting the binding of PD-1 and PD-L1 and have been shown to exert therapeutic effects in various human cancers. However, to date, no monoclonal antibody that recog
Externí odkaz:
https://doaj.org/article/5dd07ae6c7cb40cfb93bf98cbdc50815
Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
Autor:
Sakuya Inanaga, Masaya Igase, Yusuke Sakai, Kenji Hagimori, Hiroshi Sunahara, Hiro Horikirizono, Kazuhito Itamoto, Kenji Baba, Yoshiharu Ohsato, Takuya Mizuno
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 5, Pp 1760-1769 (2022)
Abstract Background Microsatellite instability (MSI) is a type of genomic instability caused by mismatch repair deficiency (dMMR) in tumors. Studies on dMMR/MSI are limited, and the relationship between dMMR and MSI is unknown in tumors of dogs. Obje
Externí odkaz:
https://doaj.org/article/9090e54f56974e659aadf6d5317729fa
Autor:
Yuki Hasegawa, Kazuha Shosu, kanako Tsuji, Yumiko Shimoyama, Takako Shimokawa Miyama, Kenji Baba, Masaru Okuda, Kazuhito Itamoto, Masaya Igase, Takuya Mizuno
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract A cat was presented with mast cell tumors (MCTs) of the skin and spleen. During the initial diagnosis, the exon 8 mutation of c-KIT was detected in the masses from skin and spleen by a commercial laboratory test. Consequently, treatment with
Externí odkaz:
https://doaj.org/article/06966e80304448819f204f24bbaa5b30
Autor:
Takuya Mizuno, Misuzu Inoue, Takeaki Kubo, Yoshihide Iwaki, Kosuke Kawamoto, Kazuhito Itamoto, Satoshi Kambayashi, Masaya Igase, Kenji Baba, Masaru Okuda
Publikováno v:
Veterinary and Animal Science, Vol 17, Iss , Pp 100264- (2022)
Background: Nonregenerative anemia is occasionally seen in dogs and can be caused by many factors, among which nonregenerative immune-mediated anemia (NRIMA) and pure red cell anemia are relatively common causes. These are thought to be caused by imm
Externí odkaz:
https://doaj.org/article/43a8d914962446af9e758c169d3fd14c
Autor:
Chihiro Mochizuki, Yukihito Kayabe, Junna Nakamura, Masaya Igase, Takuya Mizuno, Michihiro Nakamura
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Radiotherapy is one of the most effective cancer treatments. Au nanoparticles (NPs) are one of the most used X-ray sensitizing materials however the effective small sub-nm size of Au NPs used for X-ray sensitizers is disadvantageous for cellular upta
Externí odkaz:
https://doaj.org/article/29b1470b48a24086957d65006c751244
Autor:
Masaya Igase, Yuki Nemoto, Kazuhito Itamoto, Kenji Tani, Munekazu Nakaichi, Masashi Sakurai, Yusuke Sakai, Shunsuke Noguchi, Masahiro Kato, Toshihiro Tsukui, Takuya Mizuno
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as well as other types of cancers. Canine oral malignant melanoma is one of the most
Externí odkaz:
https://doaj.org/article/7ea57068e99f4b3d9f9d8844f0926591
Autor:
Takuya Mizuno, Yukinari Kato, Mika K. Kaneko, Yusuke Sakai, Toshinori Shiga, Masahiro Kato, Toshihiro Tsukui, Hirofumi Takemoto, Akio Tokimasa, Kenji Baba, Yuki Nemoto, Osamu Sakai, Masaya Igase
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Lymphoma is the most common hematological cancer in dogs. Canine diffuse large B cell lymphoma shows a relatively good response to treatment with multi-agent cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy; how
Externí odkaz:
https://doaj.org/article/e1433744f59a4ad9a18dbad654843c03
Autor:
Masaya Igase, Shusaku Shibutani, Yosuke Kurogouchi, Noriyuki Fujiki, Chung Chew Hwang, Matt Coffey, Shunsuke Noguchi, Yuki Nemoto, Takuya Mizuno
Publikováno v:
Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 49-59 (2019)
Oncolytic virotherapy using reovirus is a promising new anti-cancer treatment with potential for use in humans and dogs. Because reovirus monotherapy shows limited efficacy in human and canine cancer patients, the clinical development of a combinatio
Externí odkaz:
https://doaj.org/article/76ffdd340a124cacb754bd898274c7bb
Publikováno v:
Frontiers in Virology, Vol 1 (2021)
Endogenous retroviruses (ERVs) are remnants of ancestral retroviruses that infected host germ cells in the past. Most ERVs are thought to be non-functional elements, but some ERVs retain open reading frames (ORFs) capable of expressing proteins. The
Externí odkaz:
https://doaj.org/article/5499fddd22434850a7866ce4dcdd2eca
Autor:
Nami Tateyama, Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Takuya Mizuno, Takeo Yoshikawa, Manabu Kawada, Mika K. Kaneko, Yukinari Kato
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2494 (2022)
The overexpression of epidermal growth factor receptors (EGFRs) has been reported in various human tumors, including breast, gastric, lung, colorectal, and pancreatic cancers. Humanized anti-EGFR and anti-human epidermal growth factor receptor 2 (HER
Externí odkaz:
https://doaj.org/article/b6817d1f8c054a10bdd630cad1d3a741