Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Takuya Kumamoto"'
Autor:
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent prote
Externí odkaz:
https://doaj.org/article/6905b40dd76244c5a441fae6f3e08a09
Autor:
Takuya Kumamoto, Mika Kainuma, Azusa Takahashi, Yoshika Matsuo, Kazuaki Katakawa, Takaaki Taguchi, Koji Ichinose
Publikováno v:
Molecules, Vol 26, Iss 21, p 6397 (2021)
In this article, we report the total synthesis of 6-deoxydihydrokalafungin (DDHK), a key biosynthetic intermediate of a dimeric benzoisochromanequinone antibiotic, actinorhodin (ACT), and its epimer, epi-DDHK. Tricyclic hemiacetal with 3-siloxyethyl
Externí odkaz:
https://doaj.org/article/95b1e4ae72584a8a99ccff564079d48e
Autor:
Hiromi Sato, Ryota Yamada, Midori Yanagihara, Hiroko Okuzawa, Hiroki Iwata, Ayako Kurosawa, Saki Ichinomiya, Rina Suzuki, Hiroyuki Okabe, Tomohiro Yano, Takuya Kumamoto, Noriyuki Suzuki, Tsutomu Ishikawa, Koichi Ueno
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 467-478 (2012)
In this study, we describe the antitumor activity of QO-1, one of the new 2-aryl-1,4-naphthoquinone-1-oxime methyl ether derivatives. QO-1 is a derivative of macarpine, a natural occurring product from Rutaceae plant. It could potently inhibit cell g
Externí odkaz:
https://doaj.org/article/03285697438748d1b3f3266d9bef77a2
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 4, Iss 1, p 15 (2008)
Regioselective construction of 4,8,9-trioxygenated 2,3-dihydrobenz[f]indenones, key intermediates for the synthesis of kinamycin antibiotics, was achieved via Diels-Alder reactions (DAR) using 4,7-dioxygenated indanone-type compounds as dienophiles.
Externí odkaz:
https://doaj.org/article/202872efe4e04363b13de78bb845bf4e
Publikováno v:
The Journal of organic chemistry. 87(18)
The asymmetric total synthesis of angucycline antibiotics (
Publikováno v:
Chemical and Pharmaceutical Bulletin. 69:407-410
Hydantoins, including the antiepileptic drug phenytoin, contain an amide nitrogen and an imide nitrogen, both of which can be alkylated. However, due to the higher acidity of its proton, N3 can be more easily alkylated than N1 under basic conditions.
Autor:
Yuzo Koyama, Chihiro Sakumoto, Tokihiko Tamamizu, Yasuo Inoshita, Minoru Iwamoto, Takuya Kumamoto, Yoshinori Sato, Hideyoshi Tsuchiya, Hidetoshi Miyamoto
Publikováno v:
Organic Process Research & Development. 24:1294-1303
We describe the process research and development of a practical synthesis of glucokinase activator 1 as a potential drug for treating type 2 diabetes mellitus. The key structure, a 3,4-cis-difluori...
Autor:
Azusa Takahashi, Mika Kainuma, Takuya Kumamoto, Koji Ichinose, Yoshika Matsuo, Kazuaki Katakawa, Takaaki Taguchi
Publikováno v:
Molecules
Molecules, Vol 26, Iss 6397, p 6397 (2021)
Volume 26
Issue 21
Molecules, Vol 26, Iss 6397, p 6397 (2021)
Volume 26
Issue 21
In this article, we report the total synthesis of 6-deoxydihydrokalafungin (DDHK), a key biosynthetic intermediate of a dimeric benzoisochromanequinone antibiotic, actinorhodin (ACT), and its epimer, epi-DDHK. Tricyclic hemiacetal with 3-siloxyethyl
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 556:106-112
Liquid crystalline aqueous colloids of inorganic nanosheets with thickness of 1 nm and lateral size of several micrometers were prepared from exfoliation of layered niobate, and they were hierarchically organized to generate macroscopic textures thro
Publikováno v:
Chemicalpharmaceutical bulletin. 69(4)
Hydantoins, including the antiepileptic drug phenytoin, contain an amide nitrogen and an imide nitrogen, both of which can be alkylated. However, due to the higher acidity of its proton, N