Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Takuya Kawanai"'
Autor:
Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Kazuhiro Takuma, James A. Waschek, Hitoshi Hashimoto, Yukio Ago
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD). VIPR2 gene encodes the VPAC2 receptor for vasoactive intestinal peptide (VIP) and pituitary
Externí odkaz:
https://doaj.org/article/5aacf9b8b65c485995cafa3a29a95fc0
Autor:
Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura, Yukio Ago, Kazuhiro Takuma, Toshio Matsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 351-354 (2013)
Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicity in the H
Externí odkaz:
https://doaj.org/article/000fdc93b7be4ddfa86a3707dd9d800f
Autor:
Ryosuke Yamauchi, Shuto Takeuchi, Michael S. Fanselow, Abha K. Rajbhandari, Takuya Kawanai, Jesse D. Cushman, James A. Waschek, Atsuko Hayata-Takano, Hitoshi Hashimoto, Yukio Ago
Publikováno v:
Neurobiology of Learning and Memory. 145:222-231
The structurally related neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have been implicated in stress regulation and learning and memory. Several bodies of research have shown the imp
Autor:
Hitoshi Hashimoto, Toshio Matsuda, Yukio Ago, Aya Inoue, Kazuhiro Takuma, Ryo Watanabe, Yasuhiro Ooi, Shigeru Hasebe, Takuya Kawanai, Atsuki Taruta
Publikováno v:
Epilepsy Research. 115:109-112
Previous studies have shown that inhibitors of the Na(+)/Ca(2+) exchanger (NCX) attenuate seizure activity in drug-induced epilepsy models, but the role of NCX in epilepsy is not fully understood. The present study examined the effects of pentylenete
Autor:
Toshio Matsuda, Hitoshi Hashimoto, Erika Takano, Atsuko Hayata-Takano, Yuta Hara, Ryo Watanabe, Takuya Kawanai, Yuko Maeda, Shunsuke Kataoka, Yukio Ago, Kazuhiro Takuma
Publikováno v:
Pharmacology Biochemistry and Behavior. 126:43-49
We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and spatial learning disability, in male offspring. In the present stud
Autor:
Takuya Kawanai, Yukio Ago, Toshio Matsuda, Ryo Watanabe, Akira Nishimura, Yuki Ota, Kazuhiro Takuma
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 351-354 (2013)
Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicity in the HEK293 cell
Autor:
Takuya Kawanai, Hitoshi Hashimoto, Shigeru Hasebe, Toshio Matsuda, Aya Inoue, Atsuki Taruta, Yusuke Onaka, Yukio Ago, Kazuhiro Takuma, Ryo Watanabe
Publikováno v:
Neurochemical research. 41(10)
Valproic acid (VPA) is a multi-target drug and an inhibitor of histone deacetylase (HDAC). We have previously demonstrated that prenatal exposure to VPA at embryonic day 12.5 (E12.5), but not at E14.5, causes autism-like behavioral abnormalities in m
Autor:
Masahiro Fujinaga, Yasuo Oyama, Isao Kurotani, Masaya Satoh, Shoji Imai, Erika Hashimoto, Kazuki Koizumi, Takuya Kawanai, Norikazu Miyoshi
Publikováno v:
BioMetals. 24:903-914
Although cadmium-induced apoptosis of lymphocytes is one of common features in the immunotoxicity of cadmium, the membrane pathway for intracellular cadmium accumulation is not fully elucidated. To characterize membrane Cd2+ transport of rat thymocyt
Autor:
Toshiya Masuda, Yasuo Oyama, Erika Hashimoto, Yoshimi Shingai, Aya Fujimoto, Kaori Kimura, Takuya Kawanai, Toshihisa B. Oyama, Kazuki Koizumi
Publikováno v:
Toxicology in Vitro. 24:1720-1726
Many effects of sesamol, an antioxidative constituent of sesame oil, have been reported for human health benefits due to its antioxidative action. However, we recently isolated two cytotoxic products, trimer and tetramer of sesamol, from oxidation of
Autor:
Ryosuke Yamauchi, Shuto Takeuchi, Takuya Kawanai, Hitoshi Hashimoto, Yukio Ago, James A. Waschek, Atsuko Hayata-Takano
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-1