Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Takuya Iyoda"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6591 (2024)
Senescence is a physiological and pathological cellular program triggered by various types of cellular stress. Senescent cells exhibit multiple characteristic changes. Among them, the characteristic flattened and enlarged morphology exhibited in sene
Externí odkaz:
https://doaj.org/article/a2a1d553de8f42489ed2f6a3bfbc877c
Autor:
Takuya Iyoda, Asayo Ohishi, Yunong Wang, Miyabi-Shara Yokoyama, Mika Kazama, Naoyuki Okita, Sachiye Inouye, Yoshimi Nakagawa, Hitoshi Shimano, Fumio Fukai
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1825 (2024)
One of the extracellular matrix proteins, tenascin-C (TN-C), is known to be upregulated in age-related inflammatory diseases such as cancer and cardiovascular diseases. Expression of this molecule is frequently detected, especially in the macrophage-
Externí odkaz:
https://doaj.org/article/9b58e69a0f814f7d9d1b2eb19a86cc4e
Publikováno v:
Encyclopedia, Vol 1, Iss 2, Pp 350-359 (2021)
Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, is capable of inhibiting cell adhesion to the extracellular matrix (ECM). This functional site is usually buried within the m
Externí odkaz:
https://doaj.org/article/6a1704e608e64432b569dd5d308778d0
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tenascin (TN)-C is highly expressed specifically in the lesions of inflammation-related diseases, including tumors. The expression level of TN-C in tumors and the tumor stroma is positively correlated with poor prognosis. However, no drugs targeting
Externí odkaz:
https://doaj.org/article/41e8301fa7a44bcfb4168a4327b37358
Autor:
Yayoi Kawano, Viorica Patrulea, Emmanuelle Sublet, Gerrit Borchard, Takuya Iyoda, Rihoko Kageyama, Asa Morita, Satoshi Seino, Hideto Yoshida, Olivier Jordan, Takehisa Hanawa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 301 (2021)
Hyaluronic acid (HA) has been known to play an important role in wound healing process. However, the effect of molecular weight (MW) of exogenously administered HA on the wound healing process has not been fully understood. In this study, we investig
Externí odkaz:
https://doaj.org/article/60d78544f3f947008687cbbb2ee52276
Publikováno v:
Molecules, Vol 25, Iss 14, p 3239 (2020)
Matricellular proteins, which exist in association with the extracellular matrix (ECM) and ECM protein molecules, harbor functional sites within their molecular structures. These functional sites are released through proteolytic cleavage by inflammat
Externí odkaz:
https://doaj.org/article/b8b1ab0d631b4711953509614142d456
Autor:
Motomichi Fujita, Yuka Ito-Fujita, Takuya Iyoda, Manabu Sasada, Yuko Okada, Kazuma Ishibashi, Takuro Osawa, Hiroaki Kodama, Fumio Fukai, Hideo Suzuki
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2752 (2019)
Inflammatory bowel diseases increase the risk of colorectal cancer and colitis-associated colorectal cancer (CAC). Tenascin-C, a matricellular protein, is highly expressed in inflammatory bowel diseases, especially colorectal cancer. However, the rol
Externí odkaz:
https://doaj.org/article/27b6890f6ee54229a8dd63ed5fe47b2f
Autor:
Motomichi Fujita, Tetsuya Yamamoto, Takuya Iyoda, Tatsuya Fujisawa, Reo Nagai, Chikako Kudo, Manabu Sasada, Hiroaki Kodama, Fumio Fukai
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3183 (2019)
Expression level of tenascin-C is closely correlated to poor prognosis in glioblastoma patients, while the substantial role of tenascin-C responsible for aggressive progression in glioblastoma cells has not been clarified. We previously found that pe
Externí odkaz:
https://doaj.org/article/92b9937350cc4065b2fd77f663dccc67
Autor:
Takuya Iyoda, Yumi Nagamine, Yoshitomi Nakane, Yuya Tokita, Shougo Akari, Kazuki Otsuka, Motomichi Fujita, Keisuke Itagaki, You-Ichi Takizawa, Hiroaki Orita, Toshiyuki Owaki, Jyunichi Taira, Ryo Hayashi, Hiroaki Kodama, Fumio Fukai
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162525 (2016)
The acquisition of drug resistance mediated by the interaction of tumor cells with the extracellular matrix (ECM), commonly referred to as cell adhesion-mediated drug resistance (CAM-DR), has been observed not only in hematopoietic tumor cells but al
Externí odkaz:
https://doaj.org/article/7ca555ab31244a85abea6be1068b9b8c
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 4, Pp 343-349 (2011)
Abstract.: Cardiac hypertrophy is an increase in the muscle volume of the ventricle due to the enlargement of cardiac cells. Physiological cardiac hypertrophy is the normal response to healthy exercise, and pathological hypertrophy is the response to
Externí odkaz:
https://doaj.org/article/cbfe7b14a1dc44509c4d4214aeb079d6