Zobrazeno 1 - 10
of 530
pro vyhledávání: '"Takuya, Sasaki"'
Autor:
Tasuku Kayama, Atsushi Tamura, Tuo Xiaoying, Ken-Ichiro Tsutsui, Keiichi Kitajo, Takuya Sasaki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Neuronal ensemble activity entrained by local field potential (LFP) patterns underlies a variety of brain functions, including emotion, cognition, and pain perception. Recent advances in machine learning approaches may enable more effective
Externí odkaz:
https://doaj.org/article/6a9d7f1623dd4fc09d1ffedd9de0fea2
Autor:
Yusuke Hara, Aya Ichiraku, Tomoki Matsuda, Ayuko Sakane, Takuya Sasaki, Takeharu Nagai, Kazuki Horikawa
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Genetically encoded Ca2+ indicators (GECIs) are versatile for live imaging of cellular activities. Besides the brightness and dynamic range of signal change of GECIs, Ca2+ affinity is another critical parameter for successful Ca2+ imaging, a
Externí odkaz:
https://doaj.org/article/259c0f687ec14fd98ae82919e8daab9f
Autor:
Sho Nakamura, Takuya Sasaki, Yoshihisa Uenoyama, Naoko Inoue, Marina Nakanishi, Koki Yamada, Ai Morishima, Reika Suzumura, Yuri Kitagawa, Yasuhiro Morita, Satoshi Ohkura, Hiroko Tsukamura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Dysfunction of central serotonergic neurons is known to cause depressive disorders in humans, who often show reproductive and/or glucose metabolism disorders. This study examined whether dorsal raphe (DR) serotonergic neurons sense high gluc
Externí odkaz:
https://doaj.org/article/be3528368cf14b508fc910382633cc20
Autor:
Kazuma Maeda, Miki Tanimura, Yusaku Masago, Tsukasa Horiyama, Hiroshi Takemoto, Takuya Sasaki, Ryuta Koyama, Yuji Ikegaya, Koichi Ogawa
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Autism Spectrum Disorder (ASD) is a developmental condition characterized by core symptoms including social difficulties, repetitive behaviors, and sensory abnormalities. Aberrant morphology of dendritic spines within the cortex has been documented i
Externí odkaz:
https://doaj.org/article/321154be73d54a7bbfe9923a681aec5a
Autor:
Ken-ichi Dewa, Nariko Arimura, Wataru Kakegawa, Masayuki Itoh, Toma Adachi, Satoshi Miyashita, Yukiko U. Inoue, Kento Hizawa, Kei Hori, Natsumi Honjoya, Haruya Yagishita, Shinichiro Taya, Taisuke Miyazaki, Chika Usui, Shoji Tatsumoto, Akiko Tsuzuki, Hirotomo Uetake, Kazuhisa Sakai, Kazuhiro Yamakawa, Takuya Sasaki, Jun Nagai, Yoshiya Kawaguchi, Masaki Sone, Takayoshi Inoue, Yasuhiro Go, Noritaka Ichinohe, Kozo Kaibuchi, Masahiko Watanabe, Schuichi Koizumi, Michisuke Yuzaki, Mikio Hoshino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In the central nervous system, astrocytes enable appropriate synapse function through glutamate clearance from the synaptic cleft; however, it remains unclear how astrocytic glutamate transporters function at peri-synaptic contact. Here, we
Externí odkaz:
https://doaj.org/article/5cea2b1c16ce4725914dba62e22243c1
Autor:
Nathan Bénac, G. Ezequiel Saraceno, Corey Butler, Nahoko Kuga, Yuya Nishimura, Taiki Yokoi, Ping Su, Takuya Sasaki, Mar Petit-Pedrol, Rémi Galland, Vincent Studer, Fang Liu, Yuji Ikegaya, Jean-Baptiste Sibarita, Laurent Groc
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Direct interactions between receptors at the neuronal surface have long been proposed to tune signaling cascades and neuronal communication in health and disease. Yet, the lack of direct investigation methods to measure, in live neurons, the
Externí odkaz:
https://doaj.org/article/2d86b146b2a6411f89c908ab69a9fb73
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The vagus nerve crucially affects emotions and psychiatric disorders. However, the detailed neurophysiological dynamics of the vagus nerve in response to emotions and its associated pathological changes remain unclear. In this study, we demo
Externí odkaz:
https://doaj.org/article/13eea58c963c48bb879c5afa56dc7214
Autor:
Norito Katoh, Masanori Ikeda, Yukihiro Ohya, Hiroyuki Murota, Xiaofei Hu, John Liu, Hayato Niiyama, Takuya Sasaki, Eliza M. Raymundo, Hidehisa Saeki
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 1, Pp 213-232 (2023)
Abstract Introduction Upadacitinib is an oral Janus kinase inhibitor approved in multiple countries for moderate-to-severe atopic dermatitis (AD). Here we present long-term data for up to 3 years of continuous upadacitinib treatment in Japanese patie
Externí odkaz:
https://doaj.org/article/4c129502249d4a2e89226d27166dfd79
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Hippocampal pyramidal neurons exhibit diverse spike patterns and gene expression profiles. However, their relationships with single neurons are not fully understood. In this study, we designed an electrophysiology-based experimental procedure to iden
Externí odkaz:
https://doaj.org/article/15dba4495fef4d058ab2889b53e09419
Autor:
Shogo Miyamura, Ryo Oe, Takuya Nakahara, Hidenori Koresawa, Shota Okada, Shuji Taue, Yu Tokizane, Takeo Minamikawa, Taka-Aki Yano, Kunihiro Otsuka, Ayuko Sakane, Takuya Sasaki, Koji Yasutomo, Taira Kajisa, Takeshi Yasui
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Rapid, sensitive detection of biomolecules is important for biosensing of infectious pathogens as well as biomarkers and pollutants. For example, biosensing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still strongly re
Externí odkaz:
https://doaj.org/article/0f3480617d50488594764f3943db2c31