Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Takuro Niwa"'
Autor:
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104010 (2014)
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells. Human induced pluripotent stem cells were differentiated i
Externí odkaz:
https://doaj.org/article/3b19b0f151fd40d29f54261d116ecce7
Publikováno v:
Clinical Pharmacology in Drug Development. 11:707-716
NPC-21 (EV2038) is a fully human monoclonal antibody that targets the antigenic domain 1 of glycoprotein B on the human cytomegalovirus (hCMV) envelope. NPC-21 has been shown to have broadly neutralizing activity and to inhibit cell-to-cell transmiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f418331af5af5b779f46e4d7e00a5f
https://doi.org/10.1002/cpdd.1065
https://doi.org/10.1002/cpdd.1065
Autor:
Nao Kodama, Tamihide Matsunaga, Takashi Horikawa, Takuro Niwa, Yuki Kondo, Katsunori Nakamura, Tomoki Kabeya, Takahiro Iwao
Publikováno v:
Drug Metabolism and Pharmacokinetics. 31(3):193-200
We previously reported that small-molecule compounds were effective in generating pharmacokinetically functional enterocytes from human induced pluripotent stem (iPS) cells. In this study, to determine whether the compounds promote the differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292470500abbe3aa229df252f802fdfb
Autor:
Takuya Yoshimura, Noriko Harakawa, Haruhiro Okuda, Yoshiyuki Fujimura, Jun-ichi Sawada, Su-Ryang Kim, Keiko Maekawa, Takuro Niwa, Fumika Aohara, Masahiro Tohkin, Kimie Sai, Noriko Katori, Ryuichi Hasegawa, Yoshiro Saito, Mikihiko Naito
Publikováno v:
Drug Metabolism and Disposition. 38:2100-2104
CYP3A4, the major form of cytochrome P450 (P450) expressed in the adult human liver, is involved in the metabolism of approximately 50% of commonly prescribed drugs. Several genetic polymorphisms in CYP3A4 are known to affect its catalytic activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128ec6d9b374acf2d78e94c20d53e1e1
https://doi.org/10.1124/dmd.110.034140
https://doi.org/10.1124/dmd.110.034140
Autor:
T Yoshimura, Takuro Niwa, Keiko Maekawa, Shizuo Narimatsu, K Iwasaki, F Aohara, Y Fujimura, Jun-ichi Sawada, Chie Emoto, Yoshiro Saito, Nobumitsu Hanioka
Publikováno v:
Xenobiotica. 39:140-147
1. To assess the substrate-dependent effects of the low-activity allele of human CYP3A4, CYP3A4*16 (Thr185Ser), a recombinant wild-type (CYP3A4.1) or variant (CYP3A4.16) protein was co-expressed with human NADPH-P450 reductase in Sf21 insect cells us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce586d144154f4f6ddc2675a5b7b005
https://doi.org/10.1080/00498250802617746
https://doi.org/10.1080/00498250802617746
Autor:
Naomi Mizuno, Tsuyoshi Takahashi, Hiroyuki Kusuhara, John D. Schuetz, Takuro Niwa, Yuichi Sugiyama
Publikováno v:
Drug Metabolism and Disposition. 35:2045-2052
Edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, is used for the treatment of acute cerebral infarction. Edaravone is mainly excreted into the urine after conjugation to glucuronide or sulfate. Previous studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2b05d4ec34f14eefaf5f733143a3b2
https://doi.org/10.1124/dmd.107.016352
https://doi.org/10.1124/dmd.107.016352
Autor:
Naomi Mizuno, Takuro Niwa, Yuichi Sugiyama, Tsuyoshi Takahashi, Hiroyuki Kusuhara, Yumiko Iwase
Publikováno v:
Drug Metabolism and Disposition. 35:1429-1434
3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186; edaravone), a novel free radical scavenger, is used for the treatment of acute cerebral infarction. After marketing, a few cases of acute renal failure were reported in patients following treatment with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f426b862c634521c57a345c8ad8947
https://doi.org/10.1124/dmd.106.013912
https://doi.org/10.1124/dmd.106.013912
Autor:
Nao Kodama, Tamihide Matsunaga, Katsunori Nakamura, Takuro Niwa, Takashi Horikawa, Yuki Kondo, Tomoki Kabeya, Kouichi Kurose, Takahiro Iwao
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(4)
The small intestine plays an important role in all aspects of pharmacokinetics, but there is no system for the comprehensive evaluation of small-intestinal pharmacokinetics, including drug metabolism and absorption. In this study, we aimed to constru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef298180fb9c78afa45b17562c0e7b8
https://pubmed.ncbi.nlm.nih.gov/25650381
https://pubmed.ncbi.nlm.nih.gov/25650381
Autor:
Kaoru Takanaka, Yukiharu Nakayama, Keiichi Ida, Shunichi Kametani, Toshio Inoda, Takashi Izumi, Masato Tani, Kouichi Nakamura, Eiji Kashiyama, Shigemichi Morita, Fukuichi Ohsawa, Shuichi Sakai, Meguru Achira, Akira Kagayama, Satoru Asahi, Nobuo Osawa, Jun Morita, Yoshinobu Yoshimura, Kimitoshi Saito, Yoshiaki Terauchi, Takuro Niwa, Osamu Takenaka, Takanori Hashizume, Kiyoshi Noguchi, Toshifumi Shiraga, Yasuhiro Nakai, Satoshi Omori, Akinori Aoyama, Takashi Kuwabara, Hiroyuki Kawai, Akio Nakamura, Toshiyuki Kume, Sekio Nagayama, Masahiko Iwasaki, Takuya Yoshimura, Mitsuaki Takeuchi, Hideki Nakamura, Takashi Kawashiro, Takeshi Nakabayashi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 19:444-452
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of single nucleotide polymorphisms (SNPs) found among the Japanese population wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8022493d1f872622e180d5d0b15d9e
https://doi.org/10.2133/dmpk.19.444
https://doi.org/10.2133/dmpk.19.444
Publikováno v:
Pharmacological Reviews. 55:425-461
Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and brain, and play key roles in drug absorption, distribution, and excretion. The information on the functional characteristics of drug transporters provides impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f704d5e5fd368745a4b745d4de457b57
https://doi.org/10.1124/pr.55.3.1
https://doi.org/10.1124/pr.55.3.1