Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Takuro Kobori"'
Autor:
Suguru Kurokawa, Takuro Kobori, Masato Yoneda, Yuji Ogawa, Yasushi Honda, Takaomi Kessoku, Kento Imajo, Satoru Saito, Atsushi Nakajima, Kikuko Hotta
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Liver fibrosis is a major risk factor for hepatocellular carcinoma (HCC). We have previously reported that differentially methylated regions (DMRs) are correlated with the fibrosis stages of metabolic dysfunction-associated steato
Externí odkaz:
https://doaj.org/article/10a0dacf92ba477181dab674b90fcd60
Autor:
Takuro Kobori, Rina Doukuni, Honami Ishikawa, Yui Ito, Rie Okada, Chihiro Tanaka, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Publikováno v:
Immuno, Vol 2, Iss 1, Pp 68-84 (2022)
Immune checkpoint blockade (ICB) therapies, such as immune checkpoint inhibitors against programmed death ligand-1 (PD-L1), have not been successful in treating patients with pancreatic ductal adenocarcinoma (PDAC). Despite the critical role of PD-L1
Externí odkaz:
https://doaj.org/article/53eb69fc060d4a25ada95fd0fcb3c881
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1117 (2023)
In the past decade, immune checkpoint inhibitors have exhibited potent antitumor efficacy against multiple solid malignancies but limited efficacy against pancreatic ductal adenocarcinoma (PDAC). Cluster of differentiation (CD) 47, a member of the im
Externí odkaz:
https://doaj.org/article/2a69b17c9c9b490cbc1283e8e21a9db3
Autor:
Tokio Obata, Saori Deguchi, Jyoji Yoshitomi, Kazunori Inaba, Yoko Urashima, Takuro Kobori, Kouichi Hosomi, Noriaki Nagai, Yuichiro Nakada
Publikováno v:
PLoS ONE, Vol 17, Iss 11 (2022)
In this study, we focused on the storage conditions and investigated the effects of low-temperature storage (10°C) on the dispersibility of active components in three formulations of fluorometholone (FLU) suspension eye-drops (one original drug and
Externí odkaz:
https://doaj.org/article/226310dd40134f63babdd8d5385b5ab9
Autor:
Takuro Kobori
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 14, p 4198 (2022)
Gynecologic malignancies are a heterogeneous group of female reproductive system tumors, including cervical, endometrial, ovarian, vaginal, and vulval cancers, and are the second most commonly diagnosed female cancers around the world [...]
Externí odkaz:
https://doaj.org/article/9c291f3b89b1487fa61eb72ad539e663
Autor:
Rina Doukuni, Takuro Kobori, Chihiro Tanaka, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 13, p 3830 (2022)
Immune checkpoint blockade (ICB) therapy targeting the programmed death ligand-1 (PD-L1)/PD-1 axis has emerged as a promising treatment for uterine cervical cancer; however, only a small subset of patients with uterine cervical squamous cell carcinom
Externí odkaz:
https://doaj.org/article/4a2aca04c1c54bd383349d4ad513935d
Autor:
Chihiro Tanaka, Takuro Kobori, Rie Okada, Rina Doukuni, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Nobumasa Takagaki, Tokio Obata
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 8, p 2226 (2022)
Programmed death ligand-1 (PD-L1) is an immune checkpoint molecule widely expressed on the surface of cancer cells and is an attractive immunotherapeutic target for numerous cancer cell types. However, patients with endometrial cancer derive little c
Externí odkaz:
https://doaj.org/article/a1d372570d464b1789385e64f252b953
Autor:
Mayuka Tameishi, Honami Ishikawa, Chihiro Tanaka, Takuro Kobori, Yoko Urashima, Takuya Ito, Tokio Obata
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 9, p 2457 (2022)
Programmed death ligand–1 (PD–L1) is one of the immune checkpoint molecule localized on the plasma membrane of numerous cancer cells that negatively regulates T-cell-mediated immunosurveillance. Despite the remarkable efficacy and safety profile
Externí odkaz:
https://doaj.org/article/1b579ea492c94271983e46dc5d1c0aa5
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250889 (2021)
The ezrin/radixin/moesin (ERM) family proteins act as linkers between the actin cytoskeleton and P-glycoprotein (P-gp) and regulate the plasma membrane localization and functionality of the latter in various cancer cells. Notably, P-gp overexpression
Externí odkaz:
https://doaj.org/article/21842bb91f74427abb26058eb7734152
Publikováno v:
Molecules, Vol 26, Iss 18, p 5648 (2021)
Cancer cells employ programmed cell death ligand-1 (PD-L1), an immune checkpoint protein that binds to programmed cell death-1 (PD-1) and is highly expressed in various cancers, including cervical carcinoma, to abolish T-cell-mediated immunosurveilla
Externí odkaz:
https://doaj.org/article/49a1a63c8fd249dca0433f5954ee308f