Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Takuro, Horii"'
Autor:
Ryosuke Kobayashi, Yuki Tajika, Junki Kohmaru, Sumiyo Morita, Takuro Horii, Yoichi Mizukami, Shizu Aikawa, Yasushi Hirota, Izuho Hatada
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Embryo implantation failures are a major challenge in reproductive medicine, but the underlying mechanism remains poorly understood. Successful implantation requires dynamic remodeling of the endometrium through integrated proliferation and
Externí odkaz:
https://doaj.org/article/e712b2ec98b54d358ea32e9c927671eb
Autor:
Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Hirokazu Hirai
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101185- (2024)
The production of cell-type– and age-specific genetically modified mice is a powerful approach for unraveling unknown gene functions. Here, we present a simple and timesaving method that enables adeno-associated virus (AAV)–mediated cell-type–
Externí odkaz:
https://doaj.org/article/bb4617befc7e4be2be82205b44e86479
Autor:
Yuto TANIUCHI, Kazutaka HIRAIDE, Rilige SU, Kazune IJUIN, XingQiang WEI, Takuro HORII, Izuho HATADA, Jibak LEE
Publikováno v:
The Journal of Reproduction and Development, Vol 69, Iss 2, Pp 78-86 (2023)
RAD2lL and REC8, meiosis-specific paralogs of the canonical cohesin subunit RAD21, are essential for proper formation of axial/lateral elements of the synaptonemal complex, synapsis of homologous chromosomes, and crossover recombination in mammalian
Externí odkaz:
https://doaj.org/article/c426571354cc4661975d9e644d764ce8
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-14 (2022)
Abstract Background Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in target epigenome modificat
Externí odkaz:
https://doaj.org/article/fa1bdf137dd141a486d26548b8f7fa38
Autor:
Masanori Yoshinaga, Kyuho Han, David W. Morgens, Takuro Horii, Ryosuke Kobayashi, Tatsuaki Tsuruyama, Fabian Hia, Shota Yasukura, Asako Kajiya, Ting Cai, Pedro H. C. Cruz, Alexis Vandenbon, Yutaka Suzuki, Yukio Kawahara, Izuho Hatada, Michael C. Bassik, Osamu Takeuchi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
In this work, Yoshinaga et al. use functional CRISPR screens and in vivo analyses to show that an RNA methyltransferase METTL16 and MTR4-nuclear exosome play an essential role in maintaining erythropoiesis and regulating DNA repair in erythroblasts.
Externí odkaz:
https://doaj.org/article/f78942b01fb44792b4c4ca4cc22d55e8
Autor:
Chaomulige, Toshihiko Matsuo, Kohei Sugimoto, Mary Miyaji, Osamu Hosoya, Masashi Ueda, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 370 (2024)
Strabismus, a neuro-ophthalmological condition characterized by misalignment of the eyes, is a common ophthalmic disorder affecting both children and adults. In our previous study, we identified the microsomal glutathione S-transferase 2 (MGST2) gene
Externí odkaz:
https://doaj.org/article/3c2dd91819a646d2946af432f0cb3fff
Autor:
Satomi Yogosawa, Makiko Ohkido, Takuro Horii, Yasumasa Okazaki, Jun Nakayama, Saishu Yoshida, Shinya Toyokuni, Izuho Hatada, Mitsuru Morimoto, Kiyotsugu Yoshida
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Yogosawa et al find that mice lacking the Dyrk2 kinase display congenital malformations in multiple organs and die from respiratory failure associated with disrupted lung mesenchyme and reduced expression of Foxf1. Using an ex vivo lung culture syste
Externí odkaz:
https://doaj.org/article/da3e0f2357804a94ad84e5295d570694
Autor:
Hisako Sugimoto, Takuro Horii, Jun-Na Hirota, Yoshitake Sano, Yo Shinoda, Ayumu Konno, Hirokazu Hirai, Yasuki Ishizaki, Hajime Hirase, Izuho Hatada, Teiichi Furuichi, Tetsushi Sadakata
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract The HapMap Project is a major international research effort to construct a resource to facilitate the discovery of relationships between human genetic variations and health and disease. The Ser19Stop single nucleotide polymorphism (SNP) of h
Externí odkaz:
https://doaj.org/article/a3dea4b032d6409185ddd1ede8e42850
Autor:
Takuro Horii, Sumiyo Morita, Shinjiro Hino, Mika Kimura, Yuko Hino, Hiroshi Kogo, Mitsuyoshi Nakao, Izuho Hatada
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background Epigenetic modifications, including DNA methylation, play an important role in gene silencing and genome stability. Consequently, epigenetic dysregulation can cause several diseases, such as cancer, obesity, diabetes, autism, and
Externí odkaz:
https://doaj.org/article/ddbaf52b3f00427c813f81dfb8ab45b8
Autor:
Seiichi Hirano, Omar O. Abudayyeh, Jonathan S. Gootenberg, Takuro Horii, Ryuichiro Ishitani, Izuho Hatada, Feng Zhang, Hiroshi Nishimasu, Osamu Nureki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The RNA-guided DNA endonuclease Cas9 from Corynebacterium diphtheriae (CdCas9) recognizes a promiscuous protospacer adjacent motif (PAM). Here the authors provide insights into the CdCas9-mediated PAM recognition mechanism by determining the 2.9 Å c
Externí odkaz:
https://doaj.org/article/5de5b028ca60413797f77392310eac3b