Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Takunobu Shibata"'
Autor:
Toshihiro Sakamoto, Hisashi Iwaasa, Minoru Moriya, Takunobu Shibata, Masato Chiba, Tomoyuki Ohe, Takehiro Fukami, Yuko Mitobe, Akio Kanatani, Alcane Ishihara, Yasuyuki Ishii, Hidefumi Kitazawa, Hirobumi Takahashi, Katsumasa Nonoshita, Yuji Haga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5436-5439
A series of trans -3-oxospiro[(aza)isobenzofuran-1(3 H ),1′-cyclohexane]-4′-carboxamide derivatives were synthesized and profiled for NPY Y5 binding affinity, brain and CSF penetrability in rats, and susceptibility to human and mouse P-glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f4cfe3bcba37700c1a787719176e94
https://doi.org/10.1016/j.bmcl.2009.07.103
https://doi.org/10.1016/j.bmcl.2009.07.103
Autor:
Tetsuya Kanno, Nagaaki Sato, Toshiyuki Takahashi, Akio Kanatani, Aya Sakuraba, Hisashi Iwaasa, Tomoko Hirohashi, Takehiro Fukami, Takunobu Shibata, Masaaki Hirose, Katsumasa Nonoshita, Yuji Haga, Junko Ito
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:7501-7511
A series of phenylpiperazine derivatives were synthesized and evaluated for their neuropeptide Y (NPY) Y5 receptor antagonistic activities. The benzindane portion of 2 was replaced by 1-phenylpiperazine, resulting in novel urea derivative 3f. Subsequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60db73a33b6a2ab5ea27175a791d4d90
https://doi.org/10.1016/j.bmc.2006.07.023
https://doi.org/10.1016/j.bmc.2006.07.023
Autor:
Takunobu Shibata, Kiyoyuki Yamada, Takashi Itoh, Kozue Hayamizu, Tatsuya Fujita, Masaki Takagi, Tsuyoshi Mutou, Hideo Kigoshi, Kiyotake Suenaga, Taiji Irifune, Noboru Takada
Publikováno v:
Tetrahedron. 60:8509-8527
The bioassay-guided fractionation of the cytotoxic constituents of the Japanese sea hare Dollabella auricularia led to the isolation of aurilide ( 1 ), a 26-membered cyclodepsipeptide. The gross structure of 1 was established by spectroscopic analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59172bfffb97df1e9e1df9d250a551dd
https://doi.org/10.1016/j.tet.2004.06.125
https://doi.org/10.1016/j.tet.2004.06.125
Autor:
Takunobu Shibata, Naoko Fujino, Akane Ishihara, Hidefumi Kitazawa, Yuko Koike, Aya Sakuraba, Takehiro Fukami, Katsumasa Nonoshita, Yuji Haga, Miki Sato, Toshiyuki Takahashi, Masaaki Hirose, Nagaaki Sato, Yasuyuki Ishii, and Akio Kanatani
Publikováno v:
Journal of Medicinal Chemistry. 46:666-669
Novel arylpyrazole derivatives were synthesized and evaluated as neuropeptide Y (NPY) Y5 receptor antagonists. Compound (-)-7, which features a novel chiral 2,3-dihydro-1H-cyclopenta[a]naphthalene moiety, showed good binding affinity and antagonistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d6bea7a27fa27825995c604afba3c5
https://doi.org/10.1021/jm025513q
https://doi.org/10.1021/jm025513q
Publikováno v:
Journal of Natural Products. 61:515-518
Aurilol (1), a novel cytotoxic bromotriterpene, was isolated from the sea hare Dolabella auricularia. The structure of 1, including the absolute stereochemistry of the five stereocenters, was determined by spectroscopic and chemical analyses. Aurilol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b49ecc212cd8b3540d0a9a6f5c6d9d0
https://doi.org/10.1021/np970514k
https://doi.org/10.1021/np970514k
Autor:
Takashi Kondo, Kiyoyuki Yamada, Tsuyoshi Mutou, Makoto Ojika, Hideo Kigoshi, Takunobu Shibata
Publikováno v:
Tetrahedron Letters. 37:7299-7302
The synthesis of dolastatin G (1) and nordolastatin G (2), new cytotoxic cyclodepsipeptides from the Japanese sea hare Dolabella auricularia, was achieved enantioselectively, and the present result confirmed their stereostructures unambiguously.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9965e01ae6e09b2aab307eaa56f855a
https://doi.org/10.1016/0040-4039(96)01653-x
https://doi.org/10.1016/0040-4039(96)01653-x
Publikováno v:
Journal of the American Chemical Society. 118:1874-1880
A bioassay-directed investigation of the cytotoxic constituents of the Japanese sea hare Dolabella auricularia resulted in the isolation of two cytotoxic compounds designated dolastatin H (2) and i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8979bb641090a442f2aafef1b2db905
https://doi.org/10.1021/ja9519086
https://doi.org/10.1021/ja9519086
Autor:
Makoto Ojika, Takayuki Nemoto, Kiyoyuki Yamada, Masayuki Nakamura, Kimitoshi Nakane, Takunobu Shibata
Publikováno v:
ChemInform. 26
The absolute stereochemistry of dolastatin E ( 1 ), a cyclic hexapeptide isolated from the sea hare Dolabella auricularia , has been determined by a combination of the degradation experiments and total synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af40885166681fbe332f7f7ed6a39458
https://doi.org/10.1002/chin.199542218
https://doi.org/10.1002/chin.199542218
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c59a92933b992410e2640a063a8d001
https://doi.org/10.1002/chin.199626241
https://doi.org/10.1002/chin.199626241
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::406452e1a65cec6433b4112f68e0a4eb
https://doi.org/10.1002/chin.199702169
https://doi.org/10.1002/chin.199702169