Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Takumitsu Machida"'
Autor:
Tsutomu Kodera, Nobuhiko Kawanishi, Yoshikazu Iwasawa, Eri Taniguchi, Tsuyoshi Arai, Hiroshi Hirai, Makiko Kobayashi, Takumitsu Machida, Kazuhiro Fukasawa, Kyosuke Haze, Shinichi Hasako, Tomohiro Eguchi, Hiroko Oki, Ikuko Takahashi-Suziki, Toshiyasu Shimomura, Hidehito Kotani, Yoko Nakatsuru, Koji Ichikawa
Publikováno v:
Cell Cycle. 9:1590-1600
Abnormalities in the p16INK4a/ cyclin-dependent kinase (Cdk)4, 6/ Retinoblastoma (Rb) pathway frequently occur in various human cancers. Thus, Cdk4/6 is an attractive target for cancer therapy. Here we report the biological characterization of a 2-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7774861605d0fbfeae3a0e3bd8954f1
https://doi.org/10.4161/cc.9.8.11306
https://doi.org/10.4161/cc.9.8.11306
Autor:
Yoshikazu Iwasawa, Takahiro Ogawa, Takumitsu Machida, Aki Kawagishi, Akiko Osada, Kenichi Matsuo, Teruhiro Utsugi, Satoshi Yamashita, Ryo Hatanaka, Kenjiro Ito, Tadashi Imaoka
Publikováno v:
Molecular Cancer Therapeutics. 17:A169-A169
Background: Lysine-specific demethylase 1A (LSD1/KDM1A) is a flavin adenine dinucleotide (FAD)-dependent histone demethylase that specifically modifies histone H3 lysine 4 and lysine 9. LSD1 activity is implicated in the pathogenesis of several human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053c529424e1a9d4d0cbc7f813e0f71c
https://doi.org/10.1158/1535-7163.targ-17-a169
https://doi.org/10.1158/1535-7163.targ-17-a169
Autor:
Masato Iida, Yuko Iimura-Morita, Tsuyoshi Arai, Kyosuke Haze, Hideya Komatani, Kenji Tanaka, Takumitsu Machida
Publikováno v:
Cell Cycle. 7:3556-3563
Polo-like kinase 1 (Plk1) is a serine/threonine kinase that plays an important role in M phase progression by regulating various downstream substrates via phosphorylation. Here, we identified beta-catenin as a novel substrate of Plk1 and determined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1ab257ef90b0073cc1d69992878020
https://doi.org/10.4161/cc.7.22.7072
https://doi.org/10.4161/cc.7.22.7072
Autor:
Chinatsu Ikeura, Takashi Hayama, Hajime Morishima, Tetsuya Aoyama, Takumitsu Machida, Ikuko Suzuki-Takahashi, Toshiharu Iwama, Susumu Nishimura, Teruki Honma, Kyoko Hayashi, Kazuhiro Fukasawa, Noriaki Hashimoto, Mari Ikuta, Yoshikazu Iwasawa
Publikováno v:
Journal of Medicinal Chemistry. 44:4615-4627
As a first step in structure-based design of highly selective and potent Cdk4 inhibitors, we performed structure-based generation of a novel series of Cdk4 inhibitors. A Cdk4 homology model was constructed according to X-ray analysis of an activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d81bef313376a7f7cb791aa52b9e2ba
https://doi.org/10.1021/jm0103256
https://doi.org/10.1021/jm0103256
Autor:
Teruki Honma, Takumitsu Machida, Ikuko Suzuki-Takahashi, Hiroshi Hirai, Kazuhiro Fukasawa, Mari Ikuta, Kenji Kamata, Susumu Nishimura, Takashi Hayama
Publikováno v:
Journal of Biological Chemistry. 276:27548-27554
Genetic alteration of one or more components of the p16(INK4A)-CDK4,6/cyclin D-retinoblastoma pathway is found in more than half of all human cancers. Therefore, CDK4 is an attractive target for the development of a novel anticancer agent. However, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280b37a1bf28a7fa253be9c3a8a06130
https://doi.org/10.1074/jbc.m102060200
https://doi.org/10.1074/jbc.m102060200
Autor:
Tsutomu Kobayashi, Shinji Mizuarai, Takumitsu Machida, Hideya Komatani, Hidehito Kotani, Hiraku Itadani
Publikováno v:
Molecular Cancer, Vol 10, Iss 1, p 31 (2011)
Molecular Cancer
Molecular Cancer
Background The retinoblastoma product (RB1) is frequently deregulated in various types of tumors by mutation, deletion, or inactivation through association with viral oncoproteins. The functional loss of RB1 is recognized to be one of the hallmarks t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3a5cb05e28d403df4b77155ad5f3ca
http://www.molecular-cancer.com/content/10/1/31
http://www.molecular-cancer.com/content/10/1/31
Autor:
Yoshikazu Iwasawa, Nobuhiko Kawanishi, Tsutomu Kodera, Koji Ichikawa, Toru Takaki, Yoko Nakatsuru, Tsuyoshi Arai, Makiko Kobayashi, Hiroshi Hirai, Shinichi Hasako, Kazuhiro Fukasawa, Ikuko Takahashi-Suziki, Toshiyasu Shimomura, Takumitsu Machida, Tomohiro Eguchi, Hiroko Oki, Hidehito Kotani
Publikováno v:
Investigational new drugs. 29(4)
Deregulation of cell-cycle control is a hallmark of cancer. Thus, cyclin-dependent kinases (Cdks) are an attractive target for the development of anti-cancer drugs. Here, we report the biological characterization of a highly potent pan-Cdk inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4124a7a9bf698140e7b34c8ae338a99a
https://pubmed.ncbi.nlm.nih.gov/20084424
https://pubmed.ncbi.nlm.nih.gov/20084424
Autor:
Yoshikazu Iwasawa, Yu Onozaki, Hidehito Kotani, Akiko Watanabe, Kyosuke Haze, Chie Kadowaki, Kaori Kamijo, Morihiro Mitsuya, Toshiaki Tsujino, Hideki Kurihara, Masato Iida, Sachie Otsuki, Takumitsu Machida, Hideya Komatani, Yoko Nakatsuru, Tetsuya Sugimoto, Yoshiyuki Sato
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
A novel class of imidazopyridine derivatives was designed as PLK1 inhibitors. Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36. Compound 36 demonstrated good antitumor efficacy in xenograft nude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21345933ca0f196fa95fb32a2ff1d3f0
https://pubmed.ncbi.nlm.nih.gov/19589677
https://pubmed.ncbi.nlm.nih.gov/19589677
Publikováno v:
The EMBO journal. 16(14)
The mechanism by which fertilization initiates S-phase in the zygote is examined by manipulating the activity of MAP kinase in mature starfish eggs. These unfertilized eggs, which are arrested at G1-phase after the completion of meiosis, have high MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b55d932dc5d284514f5ed03effbb8b8
https://pubmed.ncbi.nlm.nih.gov/9250677
https://pubmed.ncbi.nlm.nih.gov/9250677
Publikováno v:
EMBO Journal; 7/15/97, Vol. 16 Issue 14, p4333-4339, 7p