Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Takumi Tashima"'
Autor:
Hongorzul Davaapil, Jack Hopkins, Nadia Bonnin, Vasiliki Papadaki, Alex Leung, Hirofumi Kosuge, Takumi Tashima, Makoto Nakakido, Ryohei Sekido, Kouhei Tsumoto, Mandeep S. Sagoo, Shin-Ichi Ohnuma
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Proline/arginine-rich end leucine-rich repeat protein (PRELP), is a small secreted proteoglycan expressed by pericytes and vascular smooth muscle cells surrounding the brain vasculature of adult mouse.Methods: We utilised a Prelp knocko
Externí odkaz:
https://doaj.org/article/bfc8b0a0b800407591f92ad772143d20
Autor:
Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando, Kouhei Tsumoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Senoo et al. describe a chemical fragment that disrupts dimerization of P-cadherin. In doing so, this fragment inhibits cadherin-mediated cell-adhesion and aggregation.
Externí odkaz:
https://doaj.org/article/78b79e1b2b4e4736a8a8908c4e78773c
Autor:
Kiyoto Kamagata, Saori Kanbayashi, Shuichi Koda, Akito Kadotani, Osamu Ubukata, Takumi Tashima
Publikováno v:
Biochemical and Biophysical Research Communications. 662:119-125
Autor:
Shinsuke Sando, Daisuke Kuroda, Shota Kudo, Sho Ito, Yutaro Saito, Kouhei Tsumoto, Akinobu Senoo, Kouhei Yoshida, Satoru Nagatoishi, Go Ueno, Takumi Tashima
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization of cadherin molecules, a small-molecule regulator of dimerization would have therapeutic potential. Herein, we describe identific
Autor:
Yutaro Saito, Kouhei Yoshida, Shota Kudo, Takumi Tashima, Shinsuke Sando, Sho Ito, Go Ueno, Satoru Nagatoishi, Kouhei Tsumoto, Akinobu Senoo
Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization of cadherin molecules, a small-molecule regulator of dimerization would have therapeutic potential. Herein, we describe identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cebde37612319b56c5e0bcb7cb37316
https://doi.org/10.1101/2020.08.30.274647
https://doi.org/10.1101/2020.08.30.274647
Autor:
Tomoya Mitani, Kouhei Tsumoto, Akinobu Senoo, Anna Moberg, Linnea N. Babol, Takumi Tashima, Shota Kudo, Satoru Nagatoishi
Publikováno v:
Chemical communications (Cambridge, England). 54(42)
The inhibitor for the homophilic dimerization of P-cadherin was discovered by SPR-based screening using fragment compounds. Our SPR assays identified a specific P-cadherin binder, which was able to inhibit the cell adhesion of living CHO cells that e
Autor:
Makoto Nakakido, Shin Ichi Ohnuma, Hiroko Iwanari, Takao Hamakubo, Takumi Tashima, Kouhei Tsumoto, Jose M. M. Caaveiro, Osamu Kusano-Arai, Hiroshi Sagara, Hitomi Mimuro, Satoru Nagatoishi
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-10 (2018)
Small leucine-rich repeat proteoglycan (SLRP) proteins have an important role in the organization of the extracellular matrix, especially in the formation of collagen fibrils. However, the mechanism governing the shape of collagen fibrils is poorly u
Publikováno v:
Biochemical and Biophysical Research Communications. 463:292-296
Osteomodulin (OMD) is a member of the small leucine-rich repeat proteoglycan family, which is involved in the organization of the extracellular matrix. OMD is located in bone tissue and is reportedly important for bone mineralization. However, the de
Publikováno v:
The Journal of the Institute of Electrical Engineers of Japan. 135:603-606