Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Takumi Sakurada"'
Autor:
Toshihiko Yoshioka, Mitsuhiro Goda, Masaya Kanda, Sayuri Itobayashi, Yugo Sugimoto, Yuki Izawa‐Ishizawa, Kenta Yagi, Fuka Aizawa, Koji Miyata, Takahiro Niimura, Hirofumi Hamano, Takumi Sakurada, Yoshito Zamami, Keisuke Ishizawa
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2369-2381 (2023)
Abstract Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods. Sodium valproic acid is a prophylactic drug candidate with a high potential for
Externí odkaz:
https://doaj.org/article/029d32cf8617441b9f94b995356e25cd
Autor:
Masaya Kanda, Mitsuhiro Goda, Akiko Maegawa, Toshihiko Yoshioka, Ami Yoshida, Koji Miyata, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Takumi Sakurada, Masayuki Chuma, Kenta Yagi, Yuki Izawa‐Ishizawa, Hiroaki Yanagawa, Yoshito Zamami, Keisuke Ishizawa
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 7, Pp 1664-1675 (2022)
Abstract Cisplatin is effective against many types of carcinoma. However, a high rate of renal damage is a clinical problem. Thus, there is a need to establish a method to prevent it. Although various compounds have been reported to be effective agai
Externí odkaz:
https://doaj.org/article/2c73c7c78bfc4986951826208aecdeae
Autor:
Ken Konaka, Kota Moriyama, Takumi Sakurada, Naoto Okada, Masaki Imanishi, Yoshito Zamami, Kazuyoshi Kawazoe, Shuji Fushitani, Keisuke Ishizawa
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 3, Iss 1, Pp 1-8 (2017)
Abstract Background In chemotherapy, the full round of treatment must be completed as scheduled to achieve the strongest therapeutic effect. However, peripheral neuropathy, a severe side effect of the chemotherapeutic agent paclitaxel, can force the
Externí odkaz:
https://doaj.org/article/b7c6b4193009430ab7d57fd15031ec2f
Autor:
Keisuke Ishizawa, Yuki Izawa-Ishizawa, Noriko Yamano, Maki Urushihara, Takumi Sakurada, Masaki Imanishi, Shoko Fujii, Asami Nuno, Licht Miyamoto, Yoshitaka Kihira, Yasumasa Ikeda, Shoji Kagami, Hiroyuki Kobori, Koichiro Tsuchiya, Toshiaki Tamaki
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86335 (2014)
Diabetic nephropathy (DN) is the major cause of end-stage renal failure. Oxidative stress is implicated in the pathogenesis of DN. Nitrosonifedipine (NO-NIF) is a weak calcium channel blocker that is converted from nifedipine under light exposure. Re
Externí odkaz:
https://doaj.org/article/171e1c4f16914815bf4922eb6ed4bbf0
Autor:
Takahiro Niimura, Masayuki Chuma, Keisuke Ishizawa, Yuya Horinouchi, Takahiro Shibata, Yuki Izawa-Ishizawa, Takumi Sakurada, Hirofumi Hamano, Shunsuke Ishida, Naoto Okada, Yasumasa Ikeda, Kimiko Fukunaga, Marin Mitstui, Hiroaki Yanagawa, Mitsuhiro Goda, Kenta Yagi, Yoshito Zamami
Publikováno v:
Cancer Medicine
Background In patients treated with bevacizumab, hypertension may be a biomarker of therapeutic efficacy. However, it is not clear whether drugs that control blood pressure influence bevacizumab's efficacy. In this study, we investigated drugs that m
Autor:
Keisuke Ishizawa, Masaki Imanishi, Ken Konaka, Sachiko Mori, Soji Kakiuchi, Tatsuhiko Saito, Takumi Sakurada, Shuji Fushitani
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1839-1845
Uridine 5'-diphospho-glucuronosyltransferase (UGT), a metabolic enzyme of irinotecan active metabolite, has two genetic polymorphisms (UGT1A1*6 and UGT1A1*28). In UGT1A1 homozygous or heterozygous patients, metabolism is delayed and the risk of devel
Autor:
Takumi Sakurada, Hiroshi Nokihara, Tadashi Koga, Yoshito Zamami, Mitsuhiro Goda, Kenta Yagi, Hirofumi Hamano, Fuka Aizawa, Hirokazu Ogino, Seidai Sato, Yasushi Kirino, Hisatsugu Goto, Yasuhiko Nishioka, Keisuke Ishizawa
Publikováno v:
The oncologist. 27(7)
Background Rash eruptions are a common side-effect of pemetrexed, for which the administration of 8 mg/day of dexamethasone for 3 days from the day preceding pemetrexed administration is recommended. This study aimed to prospectively assess the effec
Autor:
Mitsuhiro Goda, Keisuke Ishizawa, Masayuki Chuma, Rie Matsuoka, Kenta Yagi, Yasuhiko Nishioka, Naoto Okada, Takumi Sakurada, Yoshito Zamami
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Immune checkpoint inhibitors (ICIs) elicit antitumour effects by activating the host immunity and cause immune-related adverse events (irAEs). ICI-related interstitial lung disease (ICI-ILD) is a fatal irAE that is difficult to treat; moreover, its i
Autor:
Ken, Konaka, Takumi, Sakurada, Tatsuhiko, Saito, Sachiko, Mori, Masaki, Imanishi, Soji, Kakiuchi, Shuji, Fushitani, Keisuke, Ishizawa
Publikováno v:
Biologicalpharmaceutical bulletin. 42(11)
Uridine 5'-diphospho-glucuronosyltransferase (UGT), a metabolic enzyme of irinotecan active metabolite, has two genetic polymorphisms (UGT1A1*6 and UGT1A1*28). In UGT1A1 homozygous or heterozygous patients, metabolism is delayed and the risk of devel
Autor:
Keisuke Ishizawa, Yuki Izawa-Ishizawa, Masaki Imanishi, Masanori Yoshizumi, Takumi Sakurada, Koichiro Tsuchiya, Masayuki Chuma, Hiromichi Fujino, Kenshi Takechi, Eriko Sairyo, Yusuke Kohara, Yasumasa Ikeda, Toshiaki Tamaki, Keijo Fukushima, Yoshito Zamami, Yuya Horinouchi
Publikováno v:
Pharmacology. 102:287-299
Background/Aims: We have reported that nitrosonifedipine (NO-NIF), a photodegradation product of nifedipine, has strong antioxidant and endothelial protective effects, and can suppress several cardiovascular diseases in animal models. The objective o