Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Takumi Kitamoto"'
Autor:
Domenico Accili, Shivatra C Talchai, Ryotaro Bouchi, April Yun‐Kyoung Lee, Wen Du, Takumi Kitamoto, Wendy M McKimpson, Sandro Belvedere, Hua V Lin
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 7, Pp 797-804 (2024)
Abstract Insulin‐deficient (type 1) diabetes is treated by providing insulin to maintain euglycemia. The current standard of care is a quasi‐closed loop integrating automated insulin delivery with a continuous glucose monitoring sensor. Cell repl
Externí odkaz:
https://doaj.org/article/ee8eb11cae5a43188421515e83dca9c4
Identifying primary aldosteronism patients who require adrenal venous sampling: a multi-center study
Autor:
Takumi Kitamoto, Tsuyoshi Idé, Yuta Tezuka, Norio Wada, Yui Shibayama, Yuya Tsurutani, Tomoko Takiguchi, Kosuke Inoue, Sachiko Suematsu, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yuto Yamazaki, Jun Saito, Hironobu Sasano, Fumitoshi Satoh, Tetsuo Nishikawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Adrenal venous sampling (AVS) is crucial for subtyping primary aldosteronism (PA) to explore the possibility of curing hypertension. Because AVS availability is limited, efforts have been made to develop strategies to bypass it. However, it
Externí odkaz:
https://doaj.org/article/f80bebafd2a14fb49de24e560300bf9c
Autor:
Wendy M. McKimpson, Taiyi Kuo, Takumi Kitamoto, Sei Higuchi, Jason C. Mills, Rebecca A. Haeusler, Domenico Accili
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 5, Pp 733-745 (2022)
Background and Aims: Stomach cells can be converted to insulin-producing cells by Neurog3, MafA, and Pdx1 overexpression. Enteroendocrine cells can be similarly made to produce insulin by the deletion of FOXO1. Characteristics and functional properti
Externí odkaz:
https://doaj.org/article/2c7263fdf1894364af1e0072aae27e91
Autor:
Wen Du, Junqiang Wang, Taiyi Kuo, Liheng Wang, Wendy M. McKimpson, Jinsook Son, Hitoshi Watanabe, Takumi Kitamoto, Yunkyoung Lee, Remi J. Creusot, Lloyd E. Ratner, Kasi McCune, Ya-Wen Chen, Brendan H. Grubbs, Matthew E. Thornton, Jason Fan, Nishat Sultana, Bryan S. Diaz, Iyshwarya Balasubramanian, Nan Gao, Sandro Belvedere, Domenico Accili
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
As a highly regenerative organ, the intestine is a promising source for cellular reprogramming for replacing lost pancreatic β cells in diabetes. Gut enterochromaffin cells can be converted to insulin-producing cells by forkhead box O1 (FoxO1) ablat
Externí odkaz:
https://doaj.org/article/6174ce1f4c8746e499f9f6f5c41100df
Autor:
Yun-Kyoung Lee, Wen Du, Yaohui Nie, Bryan Diaz, Nishat Sultana, Takumi Kitamoto, Rudolph L. Leibel, Domenico Accili, Sandro Belvedere
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101618- (2022)
Objectives: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted in
Externí odkaz:
https://doaj.org/article/5b916d96958240c9a77147b77b3d5577
Autor:
Takumi Kitamoto, Yun-Kyoung Lee, Nishat Sultana, Hitoshi Watanabe, Wendy M. McKimpson, Wen Du, Jason Fan, Bryan Diaz, Hua V. Lin, Rudolph L. Leibel, Sandro Belvedere, Domenico Accili
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101624- (2022)
Objective: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors
Externí odkaz:
https://doaj.org/article/df93c47e5c174cc68dabf3af76c69142
Autor:
Masaya Koshizaka, Ko Ishikawa, Ryoichi Ishibashi, Yoshiro Maezawa, Kenichi Sakamoto, Daigaku Uchida, Susumu Nakamura, Masaya Yamaga, Hidetaka Yokoh, Akina Kobayashi, Shunichiro Onishi, Kazuki Kobayashi, Jun Ogino, Naotake Hashimoto, Hirotake Tokuyama, Fumio Shimada, Emi Ohara, Takahiro Ishikawa, Mayumi Shoji, Shintaro Ide, Kana Ide, Yusuke Baba, Akiko Hattori, Takumi Kitamoto, Takuro Horikoshi, Ryouta Shimofusa, Sho Takahashi, Kengo Nagashima, Yasunori Sato, Minoru Takemoto, L. Kristin Newby, Koutaro Yokote, the PRIME‐V study group
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 2, Pp 200-206 (2021)
Abstract Aims/Introduction Recent randomized clinical trials have suggested that sodium–glucose cotransporter 2 inhibitors might reduce cardiovascular events and heart failure, and have renal protective effects. Despite these remarkable benefits, t
Externí odkaz:
https://doaj.org/article/a5bbfb0922504f7fa64e1190a5344a69
Autor:
María Concepción Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, InSug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular risk. However, the mecha
Externí odkaz:
https://doaj.org/article/1bec1268dd814e7492b3638624ca8bed
Autor:
Jason Fan, Wen Du, Ja Young Kim-Muller, Jinsook Son, Taiyi Kuo, Delfina Larrea, Christian Garcia, Takumi Kitamoto, Michael J. Kraakman, Edward Owusu-Ansah, Vincenzo Cirulli, Domenico Accili
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 97-111 (2020)
Objective: Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking
Externí odkaz:
https://doaj.org/article/375623377933483ab07e7a75a8f0e1a3
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The hypothalamus-pituitary-adrenal (HPA) axis plays an important role in primary aldosteronism. Aldosterone biosynthesis is regulated not only by angiotensin II in the renin-angiotensin-aldosterone system, but also by adrenocorticotropic hormone (ACT
Externí odkaz:
https://doaj.org/article/b30fa4e29d2442a2a23bff8d07412177