Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Takumi Ito"'
Autor:
Megumi Nagahara, Satoshi Tatemoto, Takumi Ito, Otoha Fujimoto, Tetsushi Ono, Masayasu Taniguchi, Mitsuhiro Takagi, Takeshige Otoi
Publikováno v:
Frontiers in Animal Science, Vol 5 (2024)
Dairy farmers and beef cattle breeders aim for one calf per year to optimize breeding efficiency, relying on artificial insemination of both dairy and beef cows. Accurate estrus detection and timely insemination are vital for improving conception rat
Externí odkaz:
https://doaj.org/article/c49f52ae98364d1b8817f071ff017b06
Publikováno v:
Journal of Fluid Science and Technology, Vol 19, Iss 3, Pp JFST0022-JFST0022 (2024)
This study examines the behavior of two-dimensional synthetic jets generated from asymmetric stepped slots, focusing on the formation of recirculation regions and jet deflection near the slot. The effects of step length and frequency on the behavior
Externí odkaz:
https://doaj.org/article/020ae75dec4648948e08b2ffcbc97c57
Publikováno v:
IET Nanobiotechnology, Vol 17, Iss 3, Pp 197-203 (2023)
Abstract To enable the accurate reproduction of organs in vitro, and improve drug screening efficiency and regenerative medicine research, it is necessary to assemble cells with single‐cell resolution to form cell clusters. However, a method to ass
Externí odkaz:
https://doaj.org/article/493aeeb1e19549e2a2804bf5a7e75466
Autor:
Takumi Ito, Thira Rojasawasthien, Sachiko Yamashita Takeuchi, Hideto Okamoto, Nobuaki Okumura, Tomohiko Shirakawa, Takuma Matsubara, Tatsuo Kawamoto, Shoichiro Kokabu
Publikováno v:
Molecules, Vol 29, Iss 7, p 1449 (2024)
Royal jelly (RJ) is recognized as beneficial to mammalian health. Multilineage differentiation potential is an important property of mesenchymal stem cells (MSCs). C2C12 cells have an innate ability to differentiate into myogenic cells. Like MSCs, C2
Externí odkaz:
https://doaj.org/article/840a465c85824d16acd5db3e5093906b
Autor:
Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Shimizu et al. identify PLZF/ZBTB16 and its fusion proteins as pomalidomide-dependent neosubstrates of the cereblon E3 ligase. The authors also report that pomalidomide induces their degradation and thereby exerts its anti-cancer effect in leukemic c
Externí odkaz:
https://doaj.org/article/8e042573d7f949a6bd3a74bcd451d1ff
Autor:
Tetsuro Marunouchi, Takumi Ito, Sumika Onda, Lina Kyo, Kirara Takahashi, Manami Uchida, Emi Yano, Kouichi Tanonaka
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 2, Pp 192-199 (2021)
In a previous study, we suggested that the Hsp90 inhibitor 17-AAG prevents cardiac dysfunction in the failing heart following myocardial infarction in rats. Although it is assumed that the RIP1/RIP3/MLKL necroptotic pathway, which comprises client pr
Externí odkaz:
https://doaj.org/article/4cffd2e88d1742909c7c136b838bbf88
Autor:
Mitsuhito Hirano, Yoichi Imai, Yuta Kaito, Takahiko Murayama, Kota Sato, Tadao Ishida, Junichi Yamamoto, Takumi Ito, Muneyoshi Futami, Masaki Ri, Hiroshi Yasui, Tamami Denda, Yukihisa Tanaka, Yasunori Ota, Masanori Nojima, Yasuhiko Kamikubo, Noriko Gotoh, Shinsuke Iida, Hiroshi Handa, Arinobu Tojo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Abstract Background Multiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a negative effect on its prognosis. Cereblon (CRBN) is a key mediator of the bioactivities of IMi
Externí odkaz:
https://doaj.org/article/f2e71599d7d641fb9ece99c28c22cc0d
Autor:
Hideki Ando, Tomomi Sato, Takumi Ito, Junichi Yamamoto, Satoshi Sakamoto, Nobuhiro Nitta, Tomoko Asatsuma-Okumura, Nobuyuki Shimizu, Ryota Mizushima, Ichio Aoki, Takeshi Imai, Yuki Yamaguchi, Arnold J. Berk, Hiroshi Handa
Publikováno v:
iScience, Vol 15, Iss , Pp 95-108 (2019)
Summary: Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with cereblon (CRBN), a substrate receptor subunit of the CRL4 E3 ubiquitin ligase complex. CRBN was originally reported as a gene a
Externí odkaz:
https://doaj.org/article/60af45cc9cbd4bfbaae5aca5b107477a
Publikováno v:
Drying Technology. :1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f2b9e3398383f3a77a12c7d89aa42d9
https://doi.org/10.1080/07373937.2023.2212053
https://doi.org/10.1080/07373937.2023.2212053
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Thalidomide, a sedative drug that was once excluded from the market owing to its teratogenic properties, was later found to be effective in treating multiple myeloma. We had previously demonstrated that cereblon (CRBN) is the target of thalidomide em
Externí odkaz:
https://doaj.org/article/0ce3f32b6c634b1ba0fc8b64cef81290