Výsledky vyhledávání - "Takuma Shigeyama"

Bioanalysis of therapeutic monoclonal antibody by peptide adsorption-controlled LC–MS

Autor: Noriko Inoue, Takuma Shigeyama, Hidehisa Tachiki, Takeru Yamaguchi, Kazuyuki Murata, Koji Arai, Shinichi Yamane, Mitsuhiko Kawabata, Mariko Yamaoka, Mio Nakatsuji, Takeshi Okuzono, Noritaka Hashii, Yoshiro Saito, Suguru Fukuda, Akiko Ishii-Watabe, Yoshimasa Enoki, Yoshiko Tousaka, Ryoya Goda

Publikováno v: Bioanalysis. 13:265-276

Aim: We aimed to develop an easy, low-cost and versatile mass spectrometric method for the bioanalysis of a therapeutic monoclonal antibody (mAb) in human serum that employs peptide adsorption-controlled (PAC)-LC/MS using selected reaction monitoring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7483edd55a6f33ee464b8c4230b0fbec
https://doi.org/10.4155/bio-2020-0262

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Generic MS-based method for the bioanalysis of therapeutic monoclonal antibodies in nonclinical studies

Autor: Takeshi Okuzono, Hidehisa Tachiki, Noritaka Hashii, Koji Arai, Shinichi Yamane, Ryoya Goda, Yoshiro Saito, Yoshiko Tousaka, Akiko Ishii-Watabe, Takuma Shigeyama, Kazuyuki Murata, Satomi Sasahara, Noriko Inoue

Publikováno v: Bioanalysis. 12:231-243

Aim: A generic bioanalytical method was developed to quantify therapeutic IgG1 monoclonal antibodies (mAbs) in mouse sera by combining an easy sample preparation method with LC/MS using selected reaction monitoring. Materials & methods: Rituximab and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75df149c447b88f4dec693e292dcf4fe
https://doi.org/10.4155/bio-2019-0253

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α-Xylosidase plays essential roles in xyloglucan remodelling, maintenance of cell wall integrity, and seed germination in Arabidopsis thaliana

Autor: Shigeo Toh, Naoto Shibuya, Takuma Shigeyama, Asuka Watanabe, Naoki Sakurai, Naoto Kawakami, Konatsu Tokuchi

Publikováno v: Journal of Experimental Botany

Highlight Xyloglucan oligosaccharide metabolism by α-xylosidase impacts xyloglucan remodelling, the mechanical integrity of the primary cell wall of growing tissues, cell expansion, and seed germination.
Regulation and maintenance of cell wall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56b33cdd12d5384c97808b4d872026f
https://pubmed.ncbi.nlm.nih.gov/27605715

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Akademický článek

α-Xylosidase plays essential roles in xyloglucan remodelling, maintenance of cell wall integrity, and seed germination in Arabidopsis thaliana.

Autor: Takuma Shigeyama, Asuka Watanabe, Konatsu Tokuchi, Shigeo Toh, Naoto Shibuya, Naoto Kawakami, Naoki Sakurai

Publikováno v: Journal of Experimental Botany; Oct2016, Vol. 67 Issue 19, p5615-5629, 15p, 2 Color Photographs, 1 Chart, 7 Graphs

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