Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Takuma Nakatsuka"'
Autor:
Kazuya Okushin, Ryosuke Tateishi, Shinya Hirakawa, Hisateru Tachimori, Koji Uchino, Ryo Nakagomi, Tomoharu Yamada, Takuma Nakatsuka, Tatsuya Minami, Masaya Sato, Mitsuhiro Fujishiro, Kiyoshi Hasegawa, Yuichiro Eguchi, Tatsuya Kanto, Hitoshi Yoshiji, Namiki Izumi, Masatoshi Kudo, Kazuhiko Koike
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The number of cancer cases diagnosed during the coronavirus disease 2019 (COVID-19) pandemic has decreased. This study investigated the impact of the pandemic on the clinical practice of hepatocellular carcinoma (HCC) using a novel nationwid
Externí odkaz:
https://doaj.org/article/faac6bf7b5d942c8a81978239c425eca
Autor:
Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Diabetes is known to increase the risk of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Here we treat male STAM (STelic Animal Model) mice, which develop diabetes, NASH and HCC associated with dysbiosis upon low-dos
Externí odkaz:
https://doaj.org/article/00518db0b90f431a9f78d36478f351e5
Autor:
Takuma Nakatsuka, Ryosuke Tateishi
Publikováno v:
Clinical and Molecular Hepatology, Vol 29, Iss 1, Pp 51-64 (2023)
The incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide during the last few decades, in the context of an increasing prevalence of obesity and non-alcoholic fatty liver disease (NAFLD). Epidemiologic studie
Externí odkaz:
https://doaj.org/article/fd45c5086e2149bf83b86e09e5c7d96a
Autor:
Tsuyoshi Fukumoto, Tatsuya Minami, Makoto Moriyama, Tomoharu Yamada, Taijiro Wake, Mizuki Nishibatake Kinoshita, Naoto Fujiwara, Ryo Nakagomi, Takuma Nakatsuka, Masaya Sato, Kenichiro Enooku, Hayato Nakagawa, Mitsuhiro Fujishiro, Shuichiro Shiina, Kazuhiko Koike, Ryosuke Tateishi
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2496-2512 (2022)
Abstract The prognostic impact of direct‐acting antivirals (DAAs) on patients with hepatitis C‐related hepatocellular carcinoma (C‐HCC) is still unclear. This study aimed to evaluate the prognosis of C‐HCC in the DAA era. We enrolled 1237 con
Externí odkaz:
https://doaj.org/article/461437311a9e4043ab401424ae3b9137
Autor:
Akiko Eguchi, Motoh Iwasa, Minori Yamada, Yasuyuki Tamai, Ryuta Shigefuku, Hiroshi Hasegawa, Yoshifumi Hirokawa, Akinobu Hayashi, Koji Okuno, Yuki Matsushita, Takuma Nakatsuka, Kenichiro Enooku, Koji Sakaguchi, Yoshinao Kobayashi, Tetsuji Yamaguchi, Masatoshi Watanabe, Yoshiyuki Takei, Hayato Nakagawa
Publikováno v:
Hepatology Communications, Vol 6, Iss 8, Pp 1987-1999 (2022)
Abstract Caspase‐generated fragmented cytokeratin 18 (fCK18) is recognized as a useful noninvasive biomarker in the diagnosis of nonalcoholic fatty liver disease (NAFLD), particularly nonalcoholic steatohepatitis (NASH). However, fCK18 measurement
Externí odkaz:
https://doaj.org/article/f9f1c1e15e4f47858312cd5199aaa819
Autor:
Masaya Sato, Ryosuke Tateishi, Makoto Moriyama, Tsuyoshi Fukumoto, Tomoharu Yamada, Ryo Nakagomi, Mizuki Nishibatake Kinoshita, Takuma Nakatsuka, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Shuichiro Shiina, Kota Ninomiya, Satoshi Kodera, Yutaka Yatomi, Kazuhiko Koike
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 1, Pp 29-37 (2022)
Background and Aims: Radiofrequency ablation (RFA) is a widely accepted, minimally invasive treatment for hepatocellular carcinoma (HCC). This study aimed to develop a machine learning (ML) model to predict the risk of HCC recurrence after RFA treatm
Externí odkaz:
https://doaj.org/article/f63a5db4b6e24b14b1fb5d9625080dd5
Autor:
Tatsuya Minami, Ryosuke Tateishi, Naoto Fujiwara, Ryo Nakagomi, Takuma Nakatsuka, Masaya Sato, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Hidetaka Fujinaga, Masashi Izumiya, Kazuyuki Hanajiri, Yoshinari Asaoka, Yuji Kondo, Yasuo Tanaka, Motoyuki Otsuka, Takamasa Ohki, Masahiro Arai, Atsushi Tanaka, Kiyomi Yasuda, Hideaki Miura, Itsuro Ogata, Toshiro Kamoshida, Kazuaki Inoue, Yukihiro Koike, Masatoshi Akamatsu, Hiroshi Mitsui, Hajime Fujie, Keiji Ogura, Hideo Yoshida, Tomonori Wada, Kiyohiko Kurai, Hisato Maekawa, Shuntaro Obi, Takuma Teratani, Naohiko Masaki, Kayo Nagashima, Takashi Ishikawa, Naoya Kato, Kyoji Moriya, Hiroshi Yotsuyanagi, Kazuhiko Koike
Publikováno v:
Liver Cancer, Pp 1-11 (2021)
Background and Aims: It remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) with antiviral therapy. Methods: In this multicenter
Externí odkaz:
https://doaj.org/article/a624671861264ea39d61aa7dc2a09d39
Autor:
Satoshi Kawamura, Yuki Matsushita, Shigeyuki Kurosaki, Mizuki Tange, Naoto Fujiwara, Yuki Hayata, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Takahiro Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Yujin Hoshida, Atsushi Umemura, Akiko Eguchi, Tsuneo Ikenoue, Yoshihiro Hirata, Motonari Uesugi, Ryosuke Tateishi, Keisuke Tateishi, Mitsuhiro Fujishiro, Kazuhiko Koike, Hayato Nakagawa
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In this study, we assessed the impact of SREBP inhibition on NASH and liver
Externí odkaz:
https://doaj.org/article/ed503c19945242ac8be07a0dfec98388
Autor:
Takuma Nakatsuka, Keisuke Tateishi, Hiroyuki Kato, Hiroaki Fujiwara, Keisuke Yamamoto, Yotaro Kudo, Hayato Nakagawa, Yasuo Tanaka, Hideaki Ijichi, Tsuneo Ikenoue, Takeaki Ishizawa, Kiyoshi Hasegawa, Makoto Tachibana, Yoichi Shinkai, Kazuhiko Koike
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract While the significance of acquired genetic abnormalities in the initiation of hepatocellular carcinoma (HCC) has been established, the role of epigenetic modification remains unknown. Here we identified the pivotal role of histone methyltran
Externí odkaz:
https://doaj.org/article/a3fa1c47b7e247bf96aa8852abf5b1fc
Autor:
Shigeyuki Kurosaki, Hayato Nakagawa, Yuki Hayata, Satoshi Kawamura, Yuki Matsushita, Tomoharu Yamada, Koji Uchino, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Hiroto Kinoshita, Yasuo Tanaka, Takuma Nakatsuka, Yoshihiro Hirata, Keisuke Tateishi, Kazuhiko Koike
Publikováno v:
JHEP Reports, Vol 3, Iss 4, Pp 100315- (2021)
Background & Aims: Liver lobules are typically subdivided into 3 metabolic zones: zones 1, 2, and 3. However, the contribution of zonal differences in hepatocytes to liver regeneration, as well as to carcinogenic susceptibility, remains unclear. Meth
Externí odkaz:
https://doaj.org/article/eb6538ad7f884c609ff2050f2b466934